SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 02/02/2005
Version 1.6
Section 1 - Product and Company Information
Product Name PICRIC ACID, REAGENT GRADE, 98%
Product Number 197378
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
PICRIC ACID, WETTED WITH WATER 88-89-1 Yes
Formula C6H3N3O7
Synonyms Acide picrique (French) * Acido picrico (Italian)
* Carbazotic acid * C.I. 10305 *
2-Hydroxy-1,3,5-trinitrobenzene * Kyselina
pikrova (Czech) * Melinite * Nitroxanthic acid *
Phenol trinitrate * Phenol, 2,4,6-trinitro- *
Picric acid (ACGIH:OSHA) * Picronitric acid *
Pikrinezuur (Dutch) * Pikrinsaeure (German) *
Pikrynowy kwas (Polish) * 2,4,6-Trinitrofenol
(Dutch) * 2,4,6-Trinitrofenolo (Italian) *
1,3,5-Trinitrophenol * 2,4,6-Trinitrophenol *
2,4,6-Trinitrophenyl (OSHA)
RTECS Number: TJ7875000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Toxic.
Explosive when dry. Forms very sensitive explosive metallic
compounds Toxic by inhalation, in contact with skin and if
swallowed. May cause sensitization by skin contact.
Readily absorbed through skin. Target organ(s): Blood. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 4
REACTIVITY: 4
NFPA RATING
HEALTH: 3
FLAMMABILITY: 4
REACTIVITY: 4
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Dry material is explosive. If material is involved in a fire,
evacuate the area and allow it to burn. If not involved in a
fire, keep material wet.
EXPLOSION DATA
Sensitivity to Mechanical Impact: May be shock-sensitive if dry.
FLASH POINT
302 掳F 150 掳C Method: closed cup
AUTOIGNITION TEMP
300 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Contain spill. If solids are present, add water
to the solids without stirring. Recover spilled materials into a
non-metallic water impervious container. Keep spilled material
wet with water. Do not allow to dry! Use a spill response pad or
pillow damp with water to absorb remaining spilled material and
ALDRICH - 197378 www.sigma-aldrich.com Page 2
absorbent pads or pillows in accordance with governmental
requirements.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
SPECIAL REQUIREMENTS
Material must be wet at all times.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.1 MG/M3
USA MSHA Standard-air TWA 0.1 MG/M3 (SKIN)
USA OSHA. PEL 8H TWA 0.1 MG/M3 (SKIN)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 0.1 MG/M3 (SK)
STEL 0.3 MG/M3 (SK)
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 0.1 MG/M3
Poland NDSCh 0.3 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Yellow
Property Value At Temperature or Pressure
Molecular Weight 229.11 AMU
ALDRICH - 197378 www.sigma-aldrich.com Page 3
pH N/A
BP/BP Range N/A
MP/MP Range 121 掳C
Freezing Point N/A
Vapor Pressure 1 mmHg 195 掳C
Vapor Density 7.9 g/l
Saturated Vapor Conc. N/A
SG/Density 1.8 g/cm3 20 掳C
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 1.33
Decomposition Temp. N/A
Flash Point 302 掳F 150 掳C Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 300 掳C
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: ACETONE, ETHANOL, ETHER
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Warning: this material is classified as
an explosive when dry. Fire fighting should be done from a remote
position. Moist solid containing 30% water. Unstable above 160掳C.
Conditions to Avoid: Picric acid forms salts with many metals some
of which are rather sensitive to heat, friction, or impact, e.g.,
lead, iron, zinc, nickel, copper, etc., and should be considered
dangerously sensitive. The salts formed with ammonia and amines,
and the molecular complexes with aromatic hydrocarbons, etc, are
in general not so sensitive. Contact of picric acid with concrete
floors may form the friction-sensitive calcium salt. Dry mixtures
of picric acid and aluminum powder are inert, but the addition of
water causes ignition after a delay dependent upon the quantity
added. Storage conditions: records of purchase dates should be
maintained for each container. Material older than 2 years should
be disposed. Inspect and add water every six months as needed.
Rotate containers to distribute water every three months.
Materials to Avoid: Strong oxidizing agents, Strong bases,
Reducing agents, Heavy metals, Heavy metal salts, Ammonia.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ALDRICH - 197378 www.sigma-aldrich.com Page 4
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
SENSITIZATION
Skin: May cause allergic skin reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Blood. Kidneys. Liver.
SIGNS AND SYMPTOMS OF EXPOSURE
May cause discoloration of the skin. Picric acid dust causes
sensitization dermatitis. This usually occurs on the face,
especially around the mouth and the sides of the nose; the
condition progresses from edema, through the formation of
papules and vesicles, to ultimate desquamation. Inhalation of
high concentrations of dust has caused unconsciousness,
weakness, muscle pain, and kidney problems. Swallowing picric
acid may cause a bitter taste, headache, dizziness, nausea,
vomiting, and diarrhea. High doses may cause destruction of the
red blood cells and damage to the kidneys and liver with blood
in the urine.
TOXICITY DATA
Oral
Rat
< 200 mg/kg
LD50
Oral
Rat
200 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Chromodacryorrhea. Behavioral:Tremor.
Behavioral:Convulsions or effect on seizure threshold.
Intraperitoneal
Mouse
56300 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
IRRITATION DATA
Eyes
Rabbit
Remarks: No irritation effect
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 575 mg/l
ALDRICH - 197378 www.sigma-aldrich.com Page 5
Test Type: EC50 Algae
Species: Selenastrum capricornutum resp.
Time: 72 h
Value: 324 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 80 - 102 mg/l
Test Type: LC50 Fish
Species: Cyprinodon variegatus (Sheepshead minnow)
Time: 96 h
Value: 100 - 170 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 106 - 114 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 160 - 180 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Trinitrophenol, wetted [with not
less than 30 percent water, by mass]
UN#: 1344
Class: 4.1
Packing Group: Packing Group I
Hazard Label: Flammable solid
PIH: Not PIH
IATA
Proper Shipping Name: Trinitrophenol, wetted
IATA UN Number: 1344
Hazard Class: 4.1
Packing Group: I
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: F T
Indication of Danger: Highly Flammable. Toxic.
R: 1 4 11 23/24/25
Risk Statements: Explosive when dry. Forms very sensitive
explosive metallic compounds Highly flammable. Toxic by
inhalation, in contact with skin and if swallowed.
S: 36/37 35 45
Safety Statements: Wear suitable protective clothing and gloves.
This material and its container must be disposed of in a safe
ALDRICH - 197378 www.sigma-aldrich.com Page 6
way. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Toxic.
Risk Statements: Explosive when dry. Forms very sensitive
explosive metallic compounds Toxic by inhalation, in contact
with skin and if swallowed. May cause sensitization by skin
contact.
Safety Statements: Keep container tightly closed and in
well-ventilated place. This material and its container must be
disposed of in a safe way. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
US Statements: Readily absorbed through skin. Target organ(s):
Blood. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
ALDRICH - 197378 www.sigma-aldrich.com Page 7
|