SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 07/26/2004
Version 1.4
Section 1 - Product and Company Information
Product Name LEAD(II) NITRATE, 99+%, A.C.S.
REAGENT
Product Number 228621
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
LEAD(II) NITRATE 10099-74-8 Yes
Formula Pb(NO3)2
Synonyms Lead dinitrate * Lead(2+) nitrate * Lead(II)
nitrate * Nitric acid, lead(2+) salt * Nitrate de
plomb (French) * Plumbous nitrate
RTECS Number: OG2100000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Oxidizing. Toxic. Dangerous for the environment.
May cause harm to the unborn child. Contact with combustible
material may cause fire. Harmful by inhalation and if swallowed.
Irritating to eyes, respiratory system and skin. Danger of
cumulative effects. Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment. Possible
risk of impaired fertility.
Calif. Prop. 65 carcinogen. Target organ(s): Nerves. Blood.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 3
SPECIAL HAZARD(S): Oxidizer
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Contact with other material may cause fire. May accelerate
combustion.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
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Suitable: Keep tightly closed. Keep away from combustible
materials, heat, sparks, and open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Remove and wash contaminated
clothing promptly.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 0.05 MG(PB)/M3
Remarks: animal carcinogen
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA <0.1 MG(PB)/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 331.2 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 470 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 4.53 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
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Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong reducing agents, Organic materials,
Finely powdered metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides, Lead/lead
oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Harmful if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves. Blood. Kidneys. Male reproductive system. Female
reproductive system.
SIGNS AND SYMPTOMS OF EXPOSURE
Lead salts have been reported to cross the placenta and to
induce embryo- and feto- mortality. They also have teratogenic
effect in some animal species. No teratogenic effects have been
reported with exposure to organometallic lead compounds. Adverse
effects of lead on human reproduction, embryonic and fetal
development, and postnatal (e.g., mental) development have been
reported. Excessive exposure can affect blood, nervous, and
digestive systems. The synthesis of hemoglobin is inhibited and
results in anemia. If left untreated, neuromuscular dysfunction,
possible paralysis, and encephalopathy can result. Additional
symptoms of overexposure include: joint and muscle pain,
weakness of the extensor muscles (frequently the hand and
wrist), headache, dizziness, abdominal pain, diarrhea,
constipation, nausea, vomiting, blue line on the gums, insomnia,
and metallic taste. High body levels produce increased
cerebrospinal pressure, brain damage, and stupor leading to coma
and often death. To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly
investigated.
TOXICITY DATA
Intravenous
Rat
93 MG/KG
LD50
Intraperitoneal
Mouse
74 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
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Result: A carcinogenic risk assessment by the US EPA classifies
lead and inorganic lead compounds as B2 - inadequate human
evidence, sufficient animal evidence. The animal data is from
studies using lead salts, primarily phosphates and acetates.
There is no evidence that any of the studies cited in this
assessment used lead nitrate.
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Rat
Dose: 36 MG/KG
Route of Application: Oral
Exposure Time: (10D MALE/10D PRE-16D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Rat
Dose: 38 MG/KG
Route of Application: Oral
Exposure Time: (22W PRE)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Rat
Dose: 25 MG/KG
Route of Application: Intravenous
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Specific Developmental
Abnormalities: Body wall. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 25 MG/KG
Route of Application: Intravenous
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Hamster
Dose: 50 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Central nervous system.
Species: Hamster
Dose: 50 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Homeostasis Specific Developmental Abnormalities: Other
developmental abnormalities.
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Dose: 5 MMOL/L
Cell Type: Ascites tumor
Mutation test: DNA damage
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Species: Rat
Dose: 100 UMOL/L
Cell Type: liver
Mutation test: DNA inhibition
Species: Rat
Dose: 300 UMOL/L
Cell Type: Other cell types
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 625 UG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Parenteral
Dose: 200 UG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intravenous
Dose: 12500 UG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 10 MG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intravenous
Dose: 150 MG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Intraperitoneal
Dose: 10 MG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 450 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 1700 UMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Hamster
Dose: 3 UMOL/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 13 GM/KG
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Route of Application: Oral
Exposure Time: (6W MALE/6W PRE-3W POST)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 27 GM/KG
Route of Application: Oral
Exposure Time: (6W MALE/6W PRE-3W POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 43 MG/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 200 MG/KG
Route of Application: Oral
Exposure Time: (18D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Biochemical and metabolic.
Effects on Newborn: Physical.
Species: Rat
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (3D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 7993 UG/KG
Route of Application: Intravenous
Exposure Time: (17D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 39964 UG/KG
Route of Application: Intravenous
Exposure Time: (17D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn:
Weaning or lactation index (e.g., # alive at weaning per # alive
at day 4). Effects on Newborn: Behavioral.
Species: Rat
Dose: 25 MG/KG
Route of Application: Intravenous
Exposure Time: (15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 6624 UG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 6624 UG/KG
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Route of Application: Subcutaneous
Exposure Time: (30D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 100 MG/KG
Route of Application: Intravenous
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord).
Species: Hamster
Dose: 25 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Hamster
Dose: 50 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Lead nitrate
UN#: 1469
Class: 5.1
Packing Group: Packing Group II
Hazard Label: Oxidizer
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Lead nitrate
IATA UN Number: 1469
Hazard Class: 5.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T N
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Indication of Danger: Toxic. Dangerous for the environment.
R: 61 20/22 33 50/53 62
Risk Statements: May cause harm to the unborn child. Harmful by
inhalation and if swallowed. Danger of cumulative effects. Very
toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment. Possible risk of impaired fertility.
S: 53 45 60 61
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Oxidizing. Toxic. Dangerous for the
environment.
Risk Statements: May cause harm to the unborn child. Contact
with combustible material may cause fire. Harmful by inhalation
and if swallowed. Irritating to eyes, respiratory system and
skin. Danger of cumulative effects. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Possible risk of impaired fertility.
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Calif. Prop. 65 carcinogen. Target organ(s):
Nerves. Blood.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements - lead compounds.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
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information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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