RNA Millennium Markers鈩?-F
AMBION, INC.
Catalog #:7151
Material Safety Data Sheet
Section 1-Identification of Product
Catalog Number: 7151 For research Health: 2 Fire: 1 Stability: 0
use only.
Synonyms:
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # R-Statement S-Statement
Formamide 100 75-12-7 R-36/37/38 S-36/37/39
R-60/61
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes irritation to skin. Symptoms include redness, itching, and
pain.
Skin Absorption May be absorbed through the skin; symptoms parallel to ingestion.
Eye Contact Causes irritation, redness, and pain.
Inhalation Causes irritation to the respiratory tract. Symptoms may include
coughing, shortness of breath. Excessive inhalation of vapor may
cause symptoms that parallel ingestion, ranging from headache to
unconsciousness, depending upon the duration and level of the
exposure.
Ingestion Causes irritation to the gastrointestinal tract. Affects the central
nervous system. May cause headache, dizziness, nausea, vomiting,
abdominal pain, and unconsciousness. May affect the reproductive
system.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES
IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. AFFECTS CENTRAL NERVOUS SYSTEM.
MAY AFFECT THE REPRODUCTIVE SYSTEM.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by skin contact and subcutaneous routes. Moderately toxic by ingestion, intraperitoneal, and intramuscular
routes. An irritant to skin, eyes, and mucous membranes. Experimental teratogenic and reproductive effects. An eye
irritant. Mutation data reported. Combustible when exposed to heat or flame; can react vigorously with oxidizing
materials. Incompatible with I2, pyridine, SO3. When heated to decomposition it emits toxic fumes of Nox.
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Water, dry chemical, chemical foam or carbon dioxide.
Flashpoint (oC) and Method 154oC
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) 500oC
Explosion Data 鈥? Sensitivity to Impact Not Tested
EHS-MSDS-7151RNAMillenniumMarkers-01 Page 1 of 3 020706
RNA Millennium Markers鈩?-F
AMBION, INC.
Catalog #:7151
Material Safety Data Sheet
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Irritating and toxic gases or carbon monoxide and
ammonia may be generated by thermal decomposition or
combustion.
NFPA Health-2; Fire-1; Reactivity-0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as
specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and
recover liquid when possible. Collect liquid in an appropriate container or absorb with an inert material (e. g.,
vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as
sawdust. Do not flush to sewer!
Section 7-Handling and Storage
Handling Procedures and Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
Equipment container tightly closed. Avoid ingestion and inhalation. Keep away from heat
and sources of ignition. Ground all equipment containing material.
Store product at +4oC. Do not store in direct sunlight. Keep in a tightly closed
Storage Requirements
container, stored in a cool, dry, ventilated area. Protect against physical damage.
Isolate from incompatible substances.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 ppm
OSHA PEL Not Listed
10 ppm TWA, 15 mg/m3 TWA (NIOSH)
Other (specify)
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Wear impervious gloves.
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Wear closed toe shoes.
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Dark blue
Odor Threshold (ppm) Not Tested
Specific Gravity 1.134
Vapor Density (Air=1) 1.55
0.02 @ 20oC
Vapor Pressure (mmHg)
Evaporation Rate <1
Boiling Point (oC) 210oC
Freezing Point (oC) 2-3oC
pH 7.1
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Soluble
EHS-MSDS-7151RNAMillenniumMarkers-01 Page 2 of 3 020706
RNA Millennium Markers鈩?-F
AMBION, INC.
Catalog #:7151
Material Safety Data Sheet
Section 10-Stability and Reactivity
Chemical Stability Stable, light sensitive.
Incompatible with other substances Strong oxidizing agents, acids, bases, hygroscopic, absorbs
moisture from the air-protect from air.
Reactivity Not Tested
Hazardous Decomposition Products Toxic fumes of ammonia, carbon monoxide, carbon dioxide,
nitrogen oxides.
Section 11-Toxicological Information
Acute Effects May be harmful if inhaled, ingested, or absorbed through the skin.
Chronic Effects The substance is toxic to kidneys, liver, mucous membranes.
Irritancy of Product Eyes, skin, respiratory and gastrointestinal system.
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
LD50 Oral Rat: 5570 mg/kg
LC50 Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Experimental reproductive effects.
Teratogenicity Experimental teratogenic effects.
Embryotoxicity In animals.
Mutagenicity Mutation data reported.
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Class D-2A: material causing other toxic effects (VERY TOXIC).
[OSHA] Not Listed
[SARA] Not Listed
[TSCA] TSCA Listed
R-36/37/38 Irritating to eyes, respiratory system and skin.
R-60/61 May impair fertility. May cause harm to the unborn child.
S-36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
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