AMBION, INC. Saturated Phenol
Catalog #:9710, 9712
Material Safety Data Sheet
Section 1-Identification of Product
9710, 9712
WHMIS Classification Health: 3 Fire: 2 Stability: 1
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Phenol 95 108-95-2 Oral Rat-317 IHL-316 mg/m3
mg/kg
Tris ~5 77-86-1 Oral Rat-5900 N.A.
mg/kg
EDTA ~5 6381-92-6 N.A. N.A.
Section 3-Hazard Identification
Routes of Entry
Skin Contact Corrosive. Rapidly absorbed through the skin with systemic
poisoning effects to follow. Discoloration and severe burns may
occur, but may be disguised by a loss in pain sensation.
Skin Absorption Corrosive. Rapidly absorbed through the skin with systemic
poisoning effects to follow. Discoloration and severe burns may
occur, but may be disguised by a loss in pain sensation.
Eye Contact Corrosive. Eye burns with redness, pain, blurred vision may occur.
May cause severe damage and blindness.
Inhalation Breathing vapor, dust or mist results in digestive disturbances
(vomiting, difficulty in swallowing, diarrhea, loss of appetite). Will
irritate, possibly burn respiratory tract. Other symptoms listed under
ingestion may also occur.
Ingestion Poison. Symptoms may include burning pain in mouth and throat,
abdominal pain, nausea, vomiting, headache, dizziness, muscular
weakness, central nervous system effects, increase in heart rate,
irregular breathing, coma, and possibly death. Acute exposure is also
associated with kidney and liver damage. Ingestion of 1 gram has
been lethal to humans.
[Emergency Overview]
POISON! DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
RAPIDLY ABSORBED THROUGH SKIN. CORROSIVE. CAUSES SEVERE BURNS TO EVERY AREA
OF CONTACT. AFFECTS CENTRAL NERVOUS SYSTEM, LIVER AND KIDNEYS. COMBUSTIBLE.
WHMIS Symbols
N.A.
[Potential Health Effects]
Human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, parenteral, and
intraperitoneal routes. Moderately toxic by skin contact. A severe eye and skin irritant. Questionable carcinogen with
experimental carcinogenic and neoplastigenic data. Human mutation data reported. An experimental teratogen. Other
experimental reproductive effects. Absorption of phenolic solutions through the skin may be very rapid, and can cause
death within 30 minutes to several hours by exposure of as little as 64 square inches of skin. Lesser exposures can
cause damage to the kidneys, liver, pancreas, and spleen, and edema of the lungs. Ingestion can cause corrosion of the
lips, mouth, throat, esophagus, and stomach, and gangrene. Ingestion of 1.5 g has killed. Chronic exposures can cause
death from liver and kidney damage. Dermatitis resulting from contact with phenol or phenol-containing products is
fairly common in industry
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Version 1 Page 1 of 4 Printed: 10/21/2004
Created:090904 QC Form: 1760
Revision Date: NA
AMBION, INC. Saturated Phenol
Catalog #:9710, 9712
Material Safety Data Sheet
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
Breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid.
Section 5-Fire Fighting Measures
Flammable Flammable
Means of Extinction Water, dry chemical, or appropriate foam
Flashpoint (oC) and Method 79C (174F) CC
Upper Flammable Limit (% by volume) 1.3
Lower Flammable Limit (% by volume) 8.6
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Emits toxic fumes under fire conditions
NFPA Health: Fire: Stability:
Section 6-Accidental Release Measures
Leak and Spill Procedures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as
specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking
tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery
or disposal and place in a closed container. Do not flush to the sewer. Dry lime or soda ash may be used on spill for
neutralization. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of
reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.
Section 7-Handling and Storage
Handling Procedures and All phenol workers should be properly trained on its hazards and the proper
Equipment protective measures required. This training should also include emergency
actions. All phenol operations should be enclosed to eliminate any potential
exposure routes. Containers of this material may be hazardous when empty since
they retain product residues (dust, solids); observe all warnings and precautions
listed for the product.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. All phenol
workers should be properly trained on its hazards and the proper protective
measures required. This training should also include emergency actions. All
phenol operations should be enclosed to eliminate any potential exposure routes.
Containers of this material may be hazardous when empty since they retain
product residues (dust, solids); observe all warnings and precautions listed for
the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Phenol- 5 ppm
Phenol - TWA 5 ppm (19 mg/m3)[skin]
OSHA PEL
Tris / EDTA 鈥? none listed
Phenol - NIOSH REL: TWA 5 ppm (19 mg/m3) 250 ppm IDLH
Other (specify)
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Neoprene gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Version 1 Page 2 of 4 Printed: 10/21/2004
Created:090904 QC Form: 1760
Revision Date: NA
AMBION, INC. Saturated Phenol
Catalog #:9710, 9712
Material Safety Data Sheet
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Strong odor sweet, tarry / Colorless
Odor Threshold (ppm) Not tested
Specific Gravity Not tested
Vapor Density (Air=1) Not tested
Vapor Pressure (mmHg) Not tested
Evaporation Rate Not tested
Boiling Point (oC) Not tested
Freezing Point (oC) Not tested
6.6
pH
Coefficient of Water/Oil Distribution Not tested
[Solubility in Water] Soluble
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Oxidizers, aluminum chloride and nitrobenzene, calcium
hypochlorite, butadiene, halogens, formaldehyde, mineral
oxidizing acids, isocyanates, sodium nitrite and many other
materials. Hot liquid phenol will attack aluminum, magnesium,
lead, and zinc metals.
Reactivity Not tested
Hazardous Decomposition Products Toxic fumes of carbon monoxide, carbon dioxide
Section 11-Toxicological Information
Acute Effects Harmful if swallowed, inhaled or absorbed through skin
Chronic Effects Material is extremely destructive to tissue of the mucous membranes and upper
respiratory tract, eyes and skin; target organs include central nervous system,
kidneys, liver, pancreas, spleen
Irritancy of Product Eyes, skin, respiratory
Skin Sensitization Yes
Respiratory Sensitization Yes
Carcinogenicity
IARC (1,2A, or 2B) CAS# 108-95-2: IARC Group 3
ACGIH (A1, A2, or A3) A4 - Not Classifiable as a Human Carcinogen
A3 - Animal Carcinogen
Reproductive Toxicity CAS# 108-95-2: Oral, rat: TDLo = 300 mg/kg (female 6-15 day(s) after
conception) Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Teratogenicity CAS# 108 -95-2: Oral, rat: TDLo = 1200 mg/kg (female 6-15 day(s)
after conception) Effects on Embryo or Fetus - fetotoxicity (except
death, e.g., stunted fetus).; Oral, mouse: TDLo = 4 gm/kg (female 6-15
day(s) after conception) Specific Developmental Abnormalities -
musculoskeletal system.
Embryotoxicity Investigated
Mutagenicity CAS# 108-95-2: Mutation Test Systems - not otherwise specified:
Human, HeLa cell = 17 mg/L.; DNA Inhibition: Human, HeLa cell = 1
mmol/L.; Mutation Test Systems 鈥? not otherwise specified: Human,
Lymphocyte = 5 umol/L.; Sister Chromatid Exchange: Human,
Lymphocyte = 5 umol/L.
Name of Synergistic Not listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity This material is expected to be toxic to aquatic life. The LC50/96-hour values for
fish are between 10 and 100 mg/l.
Version 1 Page 3 of 4 Printed: 10/21/2004
Created:090904 QC Form: 1760
Revision Date: NA
AMBION, INC. Saturated Phenol
Catalog #:9710, 9712
Material Safety Data Sheet
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Phenol Solution
TDG Packing Group: III
[DOT] Hazard Class: 6.1 UN/NA: UN2821
[IMO] Not regulated
[ICAO] Not regulated
Section 15-Regulatory Information
[WHMIS Classification] Not listed
[OSHA] Listed
[SARA] 302 / 313 CAS# 108-95-2 Listed SARA 311/312: Acute: Yes Chronic:
No Fire: No Pressure: No Reactivity: No
[TSCA] CAS# 108-95-2 Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 4 of 4 Printed: 10/21/2004
Created:090904 QC Form: 1760
Revision Date: NA
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