MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
AMBION, INC AMBION, INC
2130 WOODWARD ST. LTD HUNTINGDON
AUSTIN, TX 78744 CAMBIDGESHIRE, UK PE29 6XY
(512) 651-0200 (USA) +44 1480 373 020 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
WEB ADDRESS: www.ambion.com (INTERNATIONAL)
MAIL: techserv@ambion.com MAIL: eurotech@ambion.com
SUBSTANCE: RNA RAPID EXTRACTION SOLUTION
TRADE NAMES/SYNONYMS:
US MSDS P/N 4377496; P/N 9775; P/N AM9775; 00231982
PRODUCT USE: For Research Use Only. Not for use in diagnostic procedures.
CREATION DATE: Jun 26 2006
REVISION DATE: Oct 23 2006
2. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT 1: TRADE SECRET
CAS NUMBER: TRADE SECRET
PERCENTAGE: <10
COMPONENT 2: TRADE SECRET
CAS NUMBER: TRADE SECRET
PERCENTAGE: <10
3. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=1 REACTIVITY=0
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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EMERGENCY OVERVIEW:
PHYSICAL FORM: solution
MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye
irritation, central nervous system depression
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, changes in blood pressure, nausea,
vomiting, stomach pain, chest pain, difficulty breathing, irregular
heartbeat, headache, drowsiness, dizziness, disorientation, hallucinations,
loss of coordination, internal bleeding, kidney damage, unconsciousness,
coma
LONG TERM EXPOSURE: reproductive effects
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, absorption may occur, changes in blood
pressure, nausea, vomiting, irregular heartbeat, headache, drowsiness,
dizziness, loss of coordination
LONG TERM EXPOSURE: irritation, skin disorders, absorption may occur,
reproductive effects
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, eye damage
LONG TERM EXPOSURE: irritation
INGESTION:
SHORT TERM EXPOSURE: irritation, changes in blood pressure, nausea,
vomiting, stomach pain, difficulty breathing, irregular heartbeat, headache,
drowsiness, dizziness, disorientation, hallucinations, loss of coordination,
internal bleeding, kidney damage, unconsciousness, coma
LONG TERM EXPOSURE: reproductive effects
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give
artificial respiration if not breathing. If breathing is difficult, oxygen
should be administered by qualified personnel. Get immediate medical
attention.
SKIN CONTACT: Wash skin with soap and water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention, if needed.
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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Thoroughly clean and dry contaminated clothing and shoes before reuse.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get
immediate medical attention.
INGESTION: If a large amount is swallowed, get medical attention.
NOTE TO PHYSICIAN: For inhalation, consider oxygen.
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Slight fire hazard.
EXTINGUISHING MEDIA: carbon dioxide, regular dry chemical, regular foam, water
FIRE FIGHTING: Move container from fire area if it can be done without risk.
Avoid inhalation of material or combustion by-products. Stay upwind and keep
out of low areas.
FLASH POINT: 96.00 F (35.55 C) (aqueous solution)
FLAMMABILITY CLASS (OSHA): IC
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition products or combustion: oxides of carbon
6. ACCIDENTAL RELEASE MEASURES
OCCUPATIONAL RELEASE:
Do not touch spilled material. Stop leak if possible without personal risk.
Small spills: Absorb with sand or other non-combustible material. Collect
spilled material in appropriate container for disposal. Small dry spills: Move
containers away from spill to a safe area. Keep unnecessary people away,
isolate hazard area and deny entry. Notify Local Emergency Planning Committee
and State Emergency Response Commission for release greater than or equal to
RQ (U.S. SARA Section 304). If release occurs in the U.S. and is reportable
under CERCLA Section 103, notify the National Response Center at (800)424-8802
(USA) or (202)426-2675 (USA).
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and
standards. See original container for storage recommendations. Keep separated
from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
TRADE SECRET COMPONENT 1:
400 ppm (980 mg/m3) OSHA TWA
500 ppm (1230 mg/m3) OSHA STEL (vacated by 58 FR 35338, June 30, 1993)
200 ppm ACGIH TWA
400 ppm ACGIH STEL
400 ppm (980 mg/m3) NIOSH recommended TWA 10 hour(s)
500 ppm (1225 mg/m3) NIOSH recommended STEL
VENTILATION: Provide local exhaust ventilation system. Ensure compliance with
applicable exposure limits.
EYE PROTECTION: Wear splash resistant safety goggles with a faceshield.
Provide an emergency eye wash fountain and quick drench shower in the
immediate work area.
CLOTHING: Wear appropriate chemical resistant clothing.
GLOVES: Wear appropriate chemical resistant gloves.
RESPIRATOR: Under conditions of frequent use or heavy exposure, respiratory
protection may be needed. Respiratory protection is ranked in order from
minimum to maximum. Consider warning properties before use.
Any chemical cartridge respirator with organic vapor cartridge(s).
Any chemical cartridge respirator with a full facepiece and organic vapor
cartridge(s).
Any air-purifying respirator with a full facepiece and an organic vapor
canister.
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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For Unknown Concentrations or Immediately Dangerous to Life or Health -
Any supplied-air respirator with full facepiece and operated in a
pressure-demand or other positive-pressure mode in combination with a
separate escape supply.
Any self-contained breathing apparatus with a full facepiece.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
PHYSICAL FORM: solution
ODOR: Not available
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: 8
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition.
Avoid contact with incompatible materials.
INCOMPATIBILITIES: acids, bases, combustible materials, halogens, metals,
metal salts, peroxides, oxidizing materials
HAZARDOUS DECOMPOSITION:
Thermal decomposition products or combustion: oxides of carbon
POLYMERIZATION: Will not polymerize.
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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11. TOXICOLOGICAL INFORMATION
TRADE SECRET COMPONENT 1:
IRRITATION DATA:
500 mg skin-rabbit mild; 100 mg eyes-rabbit severe; 10 mg eyes-rabbit
moderate; 100 mg/24 hour(s) eyes-rabbit moderate
TOXICITY DATA:
16000 ppm/8 hour(s) inhalation-rat LC50; 12800 mg/kg skin-rabbit LD50; 5000
mg/kg oral-rat LD50
CARCINOGEN STATUS: IARC: Human Inadequate Evidence, Animal Inadequate
Evidence, Group 3; ACGIH: A4 -Not Classifiable as a Human Carcinogen
LOCAL EFFECTS:
Irritant: inhalation, eye
ACUTE TOXICITY LEVEL:
Moderately Toxic: inhalation, ingestion
Slightly Toxic: dermal absorption
TARGET ORGANS: central nervous system
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: kidney disorders, liver disorders,
respiratory disorders, skin disorders and allergies
TRADE SECRET COMPONENT 2:
IRRITATION DATA:
250 mg/24 hour(s) skin-human mild; 25 mg/24 hour(s) skin-human mild; 25
mg/24 hour(s) skin-mouse moderate; 25 mg/24 hour(s) skin-dog mild; 50 mg/24
hour(s) skin-rabbit severe; 25 mg/24 hour(s) skin-rabbit moderate; 250 mg/24
hour(s) skin-rabbit moderate; 10 mg/24 hour(s) skin-rabbit; 50 mg/24 hour(s)
skin-rabbit mild; 100 mg/24 hour(s) eyes-rabbit moderate; 250 ug eyes-rabbit
mild; 2 mg eyes-rabbit; 10 mg eyes-rabbit moderate; 25 mg/24 hour(s)
skin-pig mild; 25 mg/24 hour(s) skin-guinea pig mild; 0.06 percent/24
hour(s) skin-human mild; 0.1 percent/24 hour(s) skin-human moderate; 0.5
percent/23 hour(s) skin-human; 0.5 percent/47 hour(s) skin-human mild; 10
percent/22 hour(s) skin-human mild; 2 percent/18 hour(s) skin-human mild; 3
percent/48 hour(s) skin-human moderate; 1 percent/48 hour(s) skin-human; 0.5
percent/24 hour(s) skin-human; 10 percent/1 hour(s) skin-rat; 1 percent/4
hour(s) skin-rat
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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TOXICITY DATA:
>3900 mg/m3/1 hour(s) inhalation-rat LC50; 1288 mg/kg oral-rat LD50
LOCAL EFFECTS:
Irritant: skin, eye
ACUTE TOXICITY LEVEL:
Moderately Toxic: ingestion
Additional toxicological data is available on the component(s) of this product. Please call 650-638-5635
or contact MSDS_Inquiry_CCRM@appliedbiosystems.com for more information.
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: No classification assigned.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: No classification assigned.
LAND TRANSPORT ADR: No classification assigned.
LAND TRANSPORT RID: No classification assigned.
AIR TRANSPORT IATA: No classification assigned.
AIR TRANSPORT ICAO: No classification assigned.
MARITIME TRANSPORT IMDG: No classification assigned.
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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15. REGULATORY INFORMATION
U.S. REGULATIONS:
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.30):
Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.40):
Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370.21):
ACUTE: Yes
CHRONIC: No
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65):
TRADE SECRET COMPONENT 1, STRONG ACID PROCESS ONLY
OSHA PROCESS SAFETY (29CFR1910.119): Not regulated.
STATE REGULATIONS:
California Proposition 65: Not regulated.
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: This product has been classified in accordance with
the hazard criteria of the CPR and the MSDS contains all of the
information required by the CPR.
NATIONAL INVENTORY STATUS:
U.S. INVENTORY (TSCA): All the components of this substance are listed on or
are exempt from the inventory. For purposes of 40 CFR 720.36, this product
is for Research and Development (R&D) Use Only.
TSCA 12(b) EXPORT NOTIFICATION: Not listed.
MSDS PART NUMBER: 4377496 US
OHS PART NUMBER: 00231982
Revision number : B
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16. OTHER INFORMATION
Copyright 1984-2006 MDL Information Systems, Inc. All rights reserved.
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