RNaseZAP庐
AMBION, INC.
Material Safety Data Sheet
Section 1-Identification of Product
Catalog #: Product Use: WHMIS Classification
9780, 9782, 9784, 9786, This product is intended for research Health: 1 Fire: 0 Stability: 1
9788 purposes only.
Synonyms: RNaseZAP Wipes
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients % CAS # EC No. Annex 1*, Index No.
(Specific)
Surfactant 1-20 Trade Trade Not Listed
Secret Secret
Symbols: Xn
RTECS: WT1050000
* Annex 1 of Council Directive 67/548/EEC
Section 3-Hazard Identification
Not listed in Annex 1 of Directive 67/548/EEC and subsequent amending Directives.
Routes of Entry
Skin Contact Mildly irritating to skin, causes dryness and a rash on continued
exposure. May cause allergic skin reactions.
Skin Absorption Mildly irritating to skin, causes dryness and a rash on continued
exposure. May cause allergic skin reaction.
Eye Contact Causes eye irritation, redness and pain.
Inhalation Causes respiratory irritation. Symptoms may include coughing,
shortness of breath. May cause allergic reaction in sensitive
individuals
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is
expected to be a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Effective Date: 111705 Page 1 of 4
MSDS-RNaseZap-9780, 9782, 9784, 9786, 9788-05
RNaseZAP庐
AMBION, INC.
Material Safety Data Sheet
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Surfactant: 10 mg/m3 TWA
OSHA PEL Surfactant: 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Environmental Exposure Controls:
As a precaution, all necessary measures should be taken to ensure that the
substance does not enter any environmental compartment.
Section 9-Physical and Chemical Properties
Physical State Liquid
Effective Date: 111705 Page 2 of 4
MSDS-RNaseZap-9780, 9782, 9784, 9786, 9788-05
RNaseZAP庐
AMBION, INC.
Material Safety Data Sheet
Odor and Appearance Odorless/Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
The above properties should be determined in accordance with the specifications of Part A of Annex V to Directive
67/548/EEC or any other comparable method.
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Eyes, skin, reparatory, gastrointestinal
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
LD50 Oral Rat: 1288 mg/kg
LC50 Inhalation Rat: >3900 mg/kg
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Skin mouse pregnant; .480 mg/kg: Reproductive effects on embryo or
fetus: Fetotoxicity; stunted fetus.
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Ecotoxicity: Toxic for aquatic organisms.
Fish toxicity: l. macrochirus LC50: 4.5 mg/L/48hr.
Daphnia toxicity: Daphnia magna EC50: 6 mg/l/48hr.
Environmental Mobility No Data.
Persistence and Degradability Biodegradation: 90%/28 days; modified OECD screening test.
Bioaccumulation Potential No appreciable bioaccumulation potential is to be expected.
Other Environmental Data BOD 99% from TOD/5 days
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. EU Directive 75/442/EEC and
Directive 91/689/EEC as amended by Directive 94/31/EC, together with any
additional requirements of the pertinent Member State. Additionally, waste
generators must consult state and local hazardous waste regulations to ensure
complete and accurate classification.
Section 14-Transport Information
UN No. Not Listed
UN Class Not Listed
UN Packing Group Not Listed
Effective Date: 111705 Page 3 of 4
MSDS-RNaseZap-9780, 9782, 9784, 9786, 9788-05
RNaseZAP庐
AMBION, INC.
Material Safety Data Sheet
UN Proper Shipping Name Not Listed
Marine Pollutant WGK Class 2: Hazard to water.
RID/ADR Not classified as hazardous for road and rail transport.
IMDG Not classified as hazardous for transport by sea.
IATA Not classified as hazardous for transport by air.
Section 15-Regulatory Information
Substance not listed in Annex I of Directive 67/548/EEC and
Health and Environmental Information
subsequent adapting directives.
According to EU Directives 67/548/EEC
as amended by 2004/739/EC
Control of Substances Hazardous to Health (COSHH) Regulation.
Relevant UK Regulations
2002; (SI 2002/2677)
The Chemicals Hazard Information and Packaging for Supply (CHIP)
Regulations. 2002 (SI 2002/2689)
Relevant German Regulations
WGK; Class 2; hazard to water; VwVwS Anh 2 Index No. 664
Storage Class VCI; 4.1 B
Instruction Sheets; M004 Irritant and Corrosive Substances.
M050 Handling Hazardous Substances.
Occupational Restrictions; Young Persons; 22 JarbSchG.
Pregnant and New Mothers; 4 and 5 MuSchRiV
None
Restriction on Marketing, Use Import or
Export in Accordance with EU Directive
76/769/EEC and EU Regulation No.
304/2004;
Not Listed
[OSHA]
Not Listed
[SARA]
Listed
[TSCA]
21/22; Harmful in contact with skin and if swallowed
Risk Statements
36/37/38; Irritating to eyes, respiratory system and skin.
26; In case of contact with eyes, rinse immediately with plenty of water
Safety Statements
and seek medical advice.
36/37; Wear suitable protective clothing and gloves.
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Effective Date: 111705 Page 4 of 4
MSDS-RNaseZap-9780, 9782, 9784, 9786, 9788-05
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