GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 1 of 10
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
GLYCINE
SYNONYMS
C2-H5-NO2, NH2-CH2COOH, "aminoacetic acid", "amino acetic acid", "aminoethanoic
acid", "amino ethanoic acd", glycocoll, Gly
PRODUCT USE
Used in organic synthesis; nutrient; biochemical research; buffering agent;
chicken-feed additive; retards rancidity in animal and vegetable fats.
Derivatives used in the manufacture of perfumes and photographic developers.
Inhibitory neurotransmitter in spinal cord; allosteric regulator of NMDA
receptors.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
NON-HAZARDOUS SUBSTANCE. NON-DANGEROUS GOODS. According to
the Criteria of NOHSC, and the ADG Code.
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 2 of 10
Section 2 - HAZARDS IDENTIFICATION
POISONS SCHEDULE
None
RISK
Ingestion may produce health damage*.
* (limited evidence).
SAFETY
Do not breathe dust.
Take off immediately all contaminated clothing.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
glycine 56-40-6 >98
Section 4 - FIRST AID MEASURES
SWALLOWED
鈥? Immediately give a glass of water.
鈥? First aid is not generally required. If in doubt, contact a Poisons
Information Centre or a doctor.
EYE
If this product comes in contact with the eyes:
鈥? Wash out immediately with fresh running water.
鈥? Ensure complete irrigation of the eye by keeping eyelids apart and away from
eye and moving the eyelids by occasionally lifting the upper and lower lids.
鈥? If pain persists or recurs seek medical attention.
鈥? Removal of contact lenses after an eye injury should only be undertaken by
skilled personnel.
SKIN
If skin contact occurs:
鈥? Immediately remove all contaminated clothing, including footwear
鈥? Flush skin and hair with running water (and soap if available).
鈥? Seek medical attention in event of irritation.
INHALED
鈥? If dust is inhaled, remove from contaminated area.
鈥? Encourage patient to blow nose to ensure clear passage of breathing.
鈥? If irritation or discomfort persists seek medical attention.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
鈥? Water spray or fog.
鈥? Foam.
鈥? Dry chemical powder.
鈥? BCF (where regulations permit).
鈥? Carbon dioxide.
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 3 of 10
Section 5 - FIRE FIGHTING MEASURES
FIRE FIGHTING
Alert Fire Brigade and tell them location and nature of hazard.
鈥? Wear breathing apparatus plus protective gloves for fire only.
鈥? Prevent, by any means available, spillage from entering drains or water
courses.
Use fire fighting procedures suitable for surrounding area.
Cool fire exposed containers with water spray from a protected location.
DO NOT approach containers suspected to be hot.
If safe to do so, remove containers from path of fire.
Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
鈥? Solid which exhibits difficult combustion or is difficult to ignite.
鈥? Avoid generating dust, particularly clouds of dust in a confined or
unventilated space as dusts may form an explosive mixture with air, and any
source of ignition, i.e. flame or spark, will cause fire or explosion. Dust
clouds generated by the fine grinding of the solid are a particular hazard;
accumulations of fine dust may burn rapidly and fiercely if ignited
鈥? Dry dust can also be charged electrostatically by turbulence, pneumatic
transport, pouring, in exhaust ducts and during transport.
鈥? Build-up of electrostatic charge may be prevented by bonding and grounding.
鈥? Powder handling equipment such as dust collectors, dryers and mills may
require additional protection measures such as explosion venting.
鈥? All movable parts coming in contact with this material should have a speed of
less than 1-meter/sec.
Combustion products include nitrogen oxides (NOx).
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids,
chlorine bleaches, pool chlorine etc. as ignition may result.
HAZCHEM
None
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
鈥? Clean up all spills immediately.
鈥? Avoid contact with skin and eyes.
鈥? Wear impervious gloves and safety glasses.
鈥? Use dry clean up procedures and avoid generating dust.
鈥? Sweep up or
鈥? Vacuum up (consider explosion-proof machines designed to be grounded during
storage and use).
鈥? Place spilled material in clean, dry, sealable, labelled container.
MAJOR SPILLS
鈥? Clear area of personnel and move upwind.
鈥? Alert Fire Brigade and tell them location and nature of hazard.
鈥? Control personal contact by using protective equipment and dust respirator.
鈥? Prevent spillage from entering drains, sewers or water courses.
鈥? Avoid generating dust.
鈥? Sweep, shovel up. Recover product wherever possible.
鈥? Put residues in labelled plastic bags or other containers for disposal.
鈥? If contamination of drains or waterways occurs, advise emergency services.
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 4 of 10
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
glycine 500 mg/m鲁
irreversible or other serious effects or symptoms which could
impair an individual's ability to take protective action is:
glycine 500 mg/m鲁
other than mild, transient adverse effects
without perceiving a clearly defined odour is:
glycine 75 mg/m鲁
The threshold concentration below which most people.
will experience no appreciable risk of health effects:
glycine 25 mg/m鲁
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ + + + + +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
鈥? Limit all unnecessary personal contact.
鈥? Wear protective clothing when risk of exposure occurs.
鈥? Use in a well-ventilated area.
鈥? When handling DO NOT eat, drink or smoke.
鈥? Always wash hands with soap and water after handling.
鈥? Avoid physical damage to containers.
鈥? Use good occupational work practice.
鈥? Observe manufacturer's storing and handling recommendations.
SUITABLE CONTAINER
Multi ply paper bag with sealed plastic liner or heavy gauge plastic bag
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so
that they are stable and secure against sliding or collapse. Check that all
containers are clearly labelled and free from leaks. Packing as recommended by
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 5 of 10
Section 7 - HANDLING AND STORAGE
manufacturer.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
Observe manufacturer's storing and handling recommendations.
Store in original containers.
Keep containers securely sealed.
Store in a cool, dry place.
Store in a well-ventilated area.
Protect containers against physical damage.
Check regularly for spills and leaks.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak
ppm mg/m鲁 ppm m5/m鲁 ppm mg/m鲁
_________________________ ________________ _____ _____ _____ _____ _____ _____
Australia Exposure glycine 10
Standards
The following materials had no OELs on our record under the following CAS or Chemwatch (CW) numbers
glycine: No data available for CAS:56-40-6
These "dusts" have little adverse effect on the lungs and do not produce toxic
effects or organic disease. Although there is no dust which does not evoke some
cellular response at sufficiently high concentrations, the cellular response
caused by P.N.O.C.s has the following characteristics:
鈥? the architecture of the air spaces remain intact,
鈥? scar tissue (collagen) is not synthesised to any degree,
鈥? tissue reaction is potentially reversible.
Extensive concentrations of P.N.O.C.s may:
鈥? seriously reduce visibility,
鈥? cause unpleasant deposits in the eyes, ears and nasal passages,
鈥? contribute to skin or mucous membrane injury by chemical or mechanical action,
per se, or by the rigorous skin cleansing procedures necessary for their
removal. [ACGIH]
This limit does not apply:
鈥? to brief exposures to higher concentrations
鈥? nor does it apply to those substances that may cause physiological impairment
at lower concentrations but for which a TLV has as yet to be determined.
This exposure standard applies to particles which
鈥? are insoluble or poorly soluble* in water or, preferably, in aqueous lung
fluid (if data is available) and
鈥? have a low toxicity (i.e.. are not cytotoxic, genotoxic, or otherwise
chemically reactive with lung tissue, and do not emit ionizing radiation, cause
immune sensitization, or cause toxic effects other than by inflammation or by a
mechanism of lung overload).
EXPOSURE STANDARDS FOR MIXTURE
"Worst Case" computer-aided prediction of spray/ mist or fume/ dust components
and concentration:
Composite Exposure Standard for Mixture (TWA) :3 mg/m鲁.
Operations which produce a spray/mist or fume/dust, introduce particulates to
the breathing zone.
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 6 of 10
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
If the breathing zone concentration of ANY of the components listed below is
exceeded, "Worst Case" considerations deem the individual to be overexposed.
Component Breathing Zone ppm Breathing Zone mg/m鲁 Mixture Conc (%).
Component Breathing Zone Mixture Conc
(mg/m鲁) (%)
glycine 3.0000 100.0
PERSONAL PROTECTION
EYE
鈥? Safety glasses with side shields.
鈥? Chemical goggles.
鈥? Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens
or restrictions on use, should be created for each workplace or task. This
should include a review of lens absorption and adsorption for the class of
chemicals in use and an account of injury experience. Medical and first-aid
personnel should be trained in their removal and suitable equipment should be
readily available. In the event of chemical exposure, begin eye irrigation
immediately and remove contact lens as soon as practicable. Lens should be
removed at the first signs of eye redness or irritation - lens should be removed
in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
PVC gloves.
Rubber gloves.
Safety footwear.
Rubber boots.
OTHER
Overalls.
鈥? Barrier cream.
鈥? Eyewash unit.
Equipment should be kept clean and in working-order.
RESPIRATOR
Protection Factor Half-Face Full-Face Powered Air
Respirator Respirator Respirator
10 x ES P1 Air-line* -- PAPR-P1 -
50 x ES Air-line** P2 PAPR-P2
100 x ES - P3 -
Air-line* -
100+ x ES - Air-line** PAPR-P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and
conditions of use determine the type of personal
protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 7 of 10
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
General exhaust is adequate under normal operating conditions. If risk of
overexposure exists, wear SAA approved respirator. Correct fit is essential to
obtain adequate protection. Provide adequate ventilation in warehouse or closed
storage areas. Air contaminants generated in the workplace possess varying
"escape" velocities which, in turn, determine the "capture velocities" of fresh
circulating air required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
solvent " "vapours " degreasing "etc. 0.25-0.5 m/s (50-100 f/min)
" evaporating from tank (in still air)
aerosols " fumes from pouring 0.5-1 m/s (100-200 f/min.)
"operations " intermittent container
"filling " low speed conveyer
"transfers " "welding " spray "drift "
plating acid "fumes " pickling
(released at low velocity into zone of
active generation)
direct "spray " spray painting in 1-2.5 m/s (200-500 f/min)
shallow "booths " drum "filling "
conveyer "loading " crusher "dusts "
gas discharge (active generation into
zone of rapid air motion)
grinding " abrasive "blasting " 2.5-10 m/s (500-2000 f/min.)
"tumbling " high speed wheel generated
dusts (released at high initial
velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or 1: Disturbing room air currents
favourable to capture
2: Contaminants of low toxicity or of 2: Contaminants of high toxicity
nuisance value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in 4: Small hood - local control only
motion
Simple theory shows that air velocity falls rapidly with distance away from the
opening of a simple extraction pipe. Velocity generally decreases with the
square of distance from the extraction point (in simple cases). Therefore the
air speed at the extraction point should be adjusted, accordingly, after
reference to distance from the contaminating source. The air velocity at the
extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min.) for
extraction of solvents generated in a tank 2 meters distant from the extraction
point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or
used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White, odourless crystals with a sweet taste. Soluble in water and
insoluble in alcohol and ether. Non-essential amino acid.
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 8 of 10
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Solubility: 25g/100 ml water @ 25C
PHYSICAL PROPERTIES
Solid.
Mixes with water.
Molecular Weight: 75.07 Boiling Range (掳C): Not available.
Melting Range (掳C): 232-236 (decomp) Specific Gravity (water=1): 1.16
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
pH (1% solution): 4.0 (0.2M aq) Vapour Pressure (kPa): Not applicable
Volatile Component (%vol): Not applicable Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not applicable Flash Point (掳C): Not applicable
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
Autoignition Temp (掳C): Not available. Decomposition Temp (掳C): > 232
State: Divided solid Viscosity: Not available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
鈥? Presence of incompatible materials.
鈥? Product is considered stable.
鈥? Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The material is moderately discomforting if swallowed in large quantity.
The material may bind to the N-methyl-D-aspartate (NMDA) neuroreceptor.The
receptor regulates the flow of ions into and out of the cell. NMDA agonists such
as glutamates may be highly toxic to nerve cells in very high doses, and may
contribute to the death of brain cells in stroke, epilepsy and neurodegenerative
diseases. Decreased supply of oxygen in stroke has been shown to result in
excess glutamate release.
Overactivation of glutamates and other excitatory amino-acids (EAAs) such as
cysteines and homocysteines cause excitement of nerve cells and eventually their
death. Excess calcium flow into the nerve cell occurs, triggering a vicious
circle of cell damage.
Blockade of the receptor can produce amnesia in animals. While NMDA antagonists
are generally safe, in high doses they may also be harmful, causing arousal,
seizures, and a schizophrenia-like psychosis.
Large doses of calcium channel blockers may produce nausea, weakness, dizziness,
drowsiness, confusion and slurred speech. Marked and prolonged low blood
pressure and slow heart rate may result from second- or third-degree heart
block, decreased cardiac output and junctional rhythms, and can cause death.
Certain NMDA receptor antagonists may produce lightheadedness, inco-ordination
and mood elevation. Side-effects of uptake of these antagonists by nerve cells
include dizziness, inco-ordination, a feeling of well-being, muscle twitches,
and initially psychic stimulations followed by dream-filled sleep. More severe
ingestions may produce visual disturbances, fever, confusion, seizures, dilated
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 9 of 10
Section 11 - TOXICOLOGICAL INFORMATION
pupils, and coma. Headache may persist for several days.
There are a number of binding sites for the NMDA receptor.
EYE
The dust may produce eye discomfort causing smarting, pain and redness.
SKIN
The material may be mildly discomforting to the skin.
INHALED
The solid/dust is discomforting to the upper respiratory tract.
Persons with impaired respiratory function, airway diseases and conditions such
as emphysema or chronic bronchitis, may incur further disability if excessive
concentrations of particulate are inhaled.
CHRONIC HEALTH EFFECTS
Principal routes of exposure are by accidental skin and eye contact and
inhalation of generated dusts. No human exposure data available. For this reason
health effects described are based on experience with chemically related
materials. As with any chemical product, contact with unprotected bare skin;
inhalation of vapour, mist or dust in work place atmosphere; or ingestion in any
form, should be avoided by observing good occupational work practice.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (rat) LD50: 7930 mg/kg Nil Reported
Section 12 - ECOLOGICAL INFORMATION
"log Pow (Verschueren 1983):" 1.78235294
"log Kow (Sangster 1997):" -3.21
log Kow: -3.03- -1.7
BOD 5 if unstated: 0.385-0.548,86%
COD: 0.46
ThOD: 0.72,0.64
Degradation Biological: sig
Section 13 - DISPOSAL CONSIDERATIONS
鈥? Recycle wherever possible or consult manufacturer for recycling options.
鈥? Consult State Land Waste Authority for disposal.
鈥? Bury or incinerate residue at an approved site.
鈥? Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
HAZCHEM
None
NOT REGULATED FOR TRANSPORT OF DANGEROUS GOODS:UN,IATA,IMDG
GLYCINE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 15-Sep-2005 CHEMWATCH 21943
A317TC CD 2006/2 Page 10 of 10
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
None
REGULATIONS
glycine (CAS: 56-40-6) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
International Council of Chemical Associations (ICCA) - High Production Volume
List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
This document is copyright. Apart from any fair dealing for the purposes of
private study, research, review or criticism, as permitted under the Copyright
Act, no part may be reproduced by any process without written permission from
CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 15-Sep-2005
Print Date: 28-Jun-2006
|