METHYL ISOBUTYL KETONE

Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                      CHEMWATCH 1245

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           Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION





PRODUCT NAME

        METHYL ISOBUTYL KETONE



SYNONYMS

       C6-H12-O, CH3COCH2CH(CH3)2, isopropylacetone, 2-methyl-4-pentanone,

       4-methylpentan-2-one, MIBK, MIK, "2-pentanone, 4-methyl-", "iso-butyl methyl

       ketone", 4-methyl-2-pentanone



PROPER SHIPPING NAME

        METHYL ISOBUTYL KETONE

        Edit



PRODUCT USE

        Used as a solvent for paints, varnishes, nitrocellulose, lacquers; manufacture

        of methyl amyl alcohol; extraction processes including extraction of uranium

        from fission products; organic synthesis; denaturant for alcohol.



SUPPLIER

Quantum Chemicals Pty Ltd

70 Quantum Close

Quantum Industrial Park

Dandenong South VIC 3175

Australia

Telephone: 1300 782 688

Emergency Tel: 1300 131 001

Fax: 1300 782 699





HAZARD RATINGS







      Flammability

          Toxicity

     Body Contact

         Reactivity

          Chronic



           SCALE:      Min/Nil=0      Low=1       Moderate=2       High=3       Extreme=4

                                 METHYL ISOBUTYL KETONE

Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                           CHEMWATCH 1245

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           Section 2 - HAZARDS IDENTIFICATION





STATEMENT OF HAZARDOUS NATURE

        HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the

        Criteria of NOHSC, and the ADG Code.









POISONS SCHEDULE

         AS5 NZS4



RISK

           Highly flammable.

           May form explosive peroxides.

           Harmful by inhalation.

           Irritating to eyes and respiratory system.

           HARMFUL-May cause lung damage if swallowed.

           Repeated exposure may cause skin dryness and cracking.

           Skin contact and/or ingestion may produce health damage*.

           Cumulative effects may result following exposure*.

           May produce skin discomfort*.

           Vapours potentially cause drowsiness and dizziness*.

           * (limited evidence).



SAFETY

           Do not breathe gas/fumes/vapour/spray.

           Wear eye/face protection.

           Use only in well ventilated areas.

           Keep container in a well ventilated place.

           Keep container tightly closed.

           Take off immediately all contaminated clothing.

           In case of contact with eyes, rinse with plenty of water and contact Doctor or

             Poisons Information Centre.





           Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS



NAME                                                                                        CAS RN         %

methyl isobutyl ketone                                                                      108-10-1       >99





           Section 4 - FIRST AID MEASURES





SWALLOWED

       If spontaneous vomiting appears imminent or occurs, hold patient's head down,

       lower than their hips to help avoid possible aspiration of vomitus.

       � Immediately give a glass of water.

       � First aid is not generally required. If in doubt, contact a Poisons

       Information Centre or a doctor.

       � If swallowed do NOT induce vomiting.

       � If vomiting occurs, lean patient forward or place on left side (head-down

       position, if possible) to maintain open airway and prevent aspiration.

       � Observe the patient carefully.

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Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                             CHEMWATCH 1245

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                                                                                    Section 4 - FIRST AID MEASURES



          � Never give liquid to a person showing signs of being sleepy or with reduced

          awareness; i.e. becoming unconscious.

          � Give water to rinse out mouth, then provide liquid slowly and as much as

          casualty can comfortably drink.

          � Seek medical advice.

          Avoid giving milk or oils.

          Avoid giving alcohol.



EYE

          If this product comes in contact with the eyes:

          � Wash out immediately with fresh running water.

          � Ensure complete irrigation of the eye by keeping eyelids apart and away from

          eye and moving the eyelids by occasionally lifting the upper and lower lids.

          � If pain persists or recurs seek medical attention.

          � Removal of contact lenses after an eye injury should only be undertaken by

          skilled personnel.



SKIN

          If skin contact occurs:

          � Immediately remove all contaminated clothing, including footwear

          � Flush skin and hair with running water (and soap if available).

          � Seek medical attention in event of irritation.



INHALED

          � If fumes or combustion products are inhaled remove from contaminated area.

          � Lay patient down. Keep warm and rested.

          � Prostheses such as false teeth, which may block airway, should be removed,

          where possible, prior to initiating first aid procedures.

          � Apply artificial respiration if not breathing, preferably with a demand valve

          resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if

          necessary.

          � Transport to hospital, or doctor, without delay.

          � If fumes or combustion products are inhaled remove from contaminated area.

          � Lay patient down. Keep warm and rested.

          � Prostheses such as false teeth, which may block airway, should be removed,

          where possible, prior to initiating first aid procedures.

          � Apply artificial respiration if not breathing, preferably with a demand valve

          resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if

          necessary.

          � Transport to hospital, or doctor.



NOTES TO PHYSICIAN

         Treat symptomatically.

         Any material aspirated during vomiting may produce lung injury. Therefore emesis

         should not be induced mechanically or pharmacologically. Mechanical means should

         be used if it is considered necessary to evacuate the stomach contents; these

         include gastric lavage after endotracheal intubation. If spontaneous vomiting

         has occurred after ingestion, the patient should be monitored for difficult

         breathing, as adverse effects of aspiration into the lungs may be delayed up to

         48 hours.

         for simple ketones:

         --------------------------------------------------------------

         BASIC TREATMENT

         --------------------------------------------------------------

         � Establish a patent airway with suction where necessary.

         � Watch for signs of respiratory insufficiency and assist ventilation as

         necessary.

         � Administer oxygen by non-rebreather mask at 10 to 15 l/min.

         � Monitor and treat, where necessary, for pulmonary oedema .

         � Monitor and treat, where necessary, for shock.

         � DO NOT use emetics. Where ingestion is suspected rinse mouth and give up to

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Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                    CHEMWATCH 1245

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                                                                           Section 4 - FIRST AID MEASURES



          200 ml water (5mL/kg recommended) for dilution where patient is able to swallow,

          has a strong gag reflex and does not drool.

          � Give activated charcoal.

          --------------------------------------------------------------

          ADVANCED TREATMENT

          --------------------------------------------------------------

          � Consider orotracheal or nasotracheal intubation for airway control in

          unconscious patient or where respiratory arrest has occurred.

          � Consider intubation at first sign of upper airway obstruction resulting from

          oedema.

          � Positive-pressure ventilation using a bag-valve mask might be of use.

          � Monitor and treat, where necessary, for arrhythmias.

          � Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers

          solution. Fluid overload might create complications.

          � Drug therapy should be considered for pulmonary oedema.

          � Hypotension with signs of hypovolaemia requires the cautious administration of

          fluids. Fluid overload might create complications.

          � Treat seizures with diazepam.

          � Proparacaine hydrochloride should be used to assist eye irrigation.

          --------------------------------------------------------------

          EMERGENCY DEPARTMENT

          --------------------------------------------------------------

          � Laboratory analysis of complete blood count, serum electrolytes, BUN,

          creatinine, glucose, urinalysis, baseline for serum aminotransferases (ALT and

          AST), calcium, phosphorus and magnesium, may assist in establishing a treatment

          regime. Other useful analyses include anion and osmolar gaps, arterial blood

          gases (ABGs), chest radiographs and electrocardiograph.

          � Positive end-expiratory pressure (PEEP)-assisted ventilation may be required

          for acute parenchymal injury or adult respiratory distress syndrome.

          � Consult a toxicologist as necessary.

          BRONSTEIN, A.C. and CURRANCE, P.L.

          EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.

          For acute or short term repeated exposures to petroleum distillates or related

          hydrocarbons:

          � Primary threat to life, from pure petroleum distillate ingestion and/or

          inhalation, is respiratory failure.

          � Patients should be quickly evaluated for signs of respiratory distress (e.g.

          cyanosis, tachypnoea, intercostal retraction, obtundation) and given oxygen.

          Patients with inadequate tidal volumes or poor arterial blood gases (pO2 50 mm

          Hg) should be intubated.

          � Arrhythmias complicate some hydrocarbon ingestion and/or inhalation and

          electrocardiographic evidence of myocardial injury has been reported;

          intravenous lines and cardiac monitors should be established in obviously

          symptomatic patients. The lungs excrete inhaled solvents, so that

          hyperventilation improves clearance.

          � A chest x-ray should be taken immediately after stabilisation of breathing and

          circulation to document aspiration and detect the presence of pneumothorax.

          � Epinephrine (adrenalin) is not recommended for treatment of bronchospasm

          because of potential myocardial sensitisation to catecholamines. Inhaled

          cardioselective bronchodilators (e.g. Alupent, Salbutamol) are the preferred

          agents, with aminophylline a second choice.

          � Lavage is indicated in patients who require decontamination; ensure use of

          cuffed endotracheal tube in adult patients. [Ellenhorn and Barceloux: Medical

          Toxicology].





          Section 5 - FIRE FIGHTING MEASURES





EXTINGUISHING MEDIA

� Alcohol stable foam.

                                   METHYL ISOBUTYL KETONE

Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                             CHEMWATCH 1245

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                                                                               Section 5 - FIRE FIGHTING MEASURES



� Dry chemical powder.

� BCF (where regulations permit).

� Carbon dioxide.

� Water spray or fog - Large fires only.

� Foam.

� Dry chemical powder.

� BCF (where regulations permit).

� Carbon dioxide.

� Water spray or fog - Large fires only.



FIRE FIGHTING

� Alert Fire Brigade and tell them location and nature of hazard.

� May be violently or explosively reactive.

� Wear breathing apparatus plus protective gloves.

� Prevent, by any means available, spillage from entering drains or water

course.

� Consider evacuation (or protect in place).

� Fight fire from a safe distance, with adequate cover.

� If safe, switch off electrical equipment until vapour fire hazard removed.

� Use water delivered as a fine spray to control the fire and cool adjacent

area.

� Avoid spraying water onto liquid pools.

� Do not approach containers suspected to be hot.

� Cool fire exposed containers with water spray from a protected location.

� If safe to do so, remove containers from path of fire.



FIRE/EXPLOSION HAZARD

� Liquid and vapour are highly flammable.

� Severe fire hazard when exposed to heat, flame and/or oxidisers.

� Vapour may travel a considerable distance to source of ignition.

� Heating may cause expansion or decomposition leading to violent rupture of

containers.

� On combustion, may emit toxic fumes of carbon monoxide (CO).

Combustion products include, carbon dioxide (CO2), formaldehyde, other pyrolysis

products typical of burning organic material.



FIRE INCOMPATIBILITY

Avoid contamination with oxidising agents i.e. nitrates, oxidising acids,

chlorine bleaches, pool chlorine etc. as ignition may result.



HAZCHEM

              3[Y]E



Personal Protective Equipment

          Breathing apparatus.

          Chemical splash suit.





              Section 6 - ACCIDENTAL RELEASE MEASURES





EMERGENCY PROCEDURES



        MINOR SPILLS

            � Remove all ignition sources.

            � Clean up all spills immediately.

            � Avoid breathing vapours and contact with skin and eyes.

            � Control personal contact by using protective equipment.

            � Contain and absorb small quantities with vermiculite or other absorbent

            material.

            � Wipe up.

                               METHYL ISOBUTYL KETONE

Chemwatch Material Safety Data Sheet (REVIEW)

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                                                                   Section 6 - ACCIDENTAL RELEASE MEASURES



          � Collect residues in a flammable waste container.



     MAJOR SPILLS

         Chemical Class: ketones



          For release onto land: recommended sorbents listed in order of priority.



          SORBENT TYPE        RANK      APPLICATION            COLLECTION       LIMITATIONS



          LAND SPILL - SMALL



          cross-linked        1      shovel      shovel             R, W, SS

          polymer -

          particulate

          cross-linked        1      throw       pitchfork          R, DGC, RT

          polymer -

          pillow

          sorbent clay        2      shovel      shovel             R,I, P

          -

          particulate

          wood fiber -        3      throw       pitchfork          R " "P "

          pillow                                                    "DGC " RT

          treated wood        3      throw       pitchfork          DGC, RT

          fiber -

          pillow

          foamed glass        4      throw       pitchfork          R " "P "

          - pillow                                                  "DGC " RT



          LAND SPILL - MEDIUM



          cross-linked        1      blower      skiploader          R,W, SS

          polymer -

          particulate

          cross-linked        2      throw       skiploader          R, DGC, RT

          polymer -

          pillow

          sorbent clay        3      blower      skiploader          R, I, P

          -

          particulate

          polypropylen        3      blower      skiploader          R, SS, DGC

          e" -

          particulate

          expanded            4      blower      skiploader          R " "I " "W

          mineral -                                                  " "P " DGC

          particulate

          polypropylen        4      throw       skiploader          DGC, RT

          e" - mat





          Legend

          DGC: Not effective where ground cover is dense

          R; Not reusable

          I: Not incinerable

          P: Effectiveness reduced when rainy

          RT:Not effective where terrain is rugged

          SS: Not for use within environmentally sensitive sites

          W: Effectiveness reduced when windy



          Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;

          R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation

          1988.

                                  METHYL ISOBUTYL KETONE

Chemwatch Material Safety Data Sheet (REVIEW)

Issue Date: 5-Jan-2006                                                                      CHEMWATCH 1245

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                                                                   Section 6 - ACCIDENTAL RELEASE MEASURES



            � Clear area of personnel and move upwind.

            � Alert Fire Brigade and tell them location and nature of hazard.

            � May be violently or explosively reactive.

            � Wear breathing apparatus plus protective gloves.

            � Prevent, by any means available, spillage from entering drains or water

            course.

            � Consider evacuation (or protect in place).

            � No smoking, naked lights or ignition sources.

            � Increase ventilation.

            � Stop leak if safe to do so.

            � Water spray or fog may be used to disperse /absorb vapour.

            � Contain spill with sand, earth or vermiculite.

            � Use only spark-free shovels and explosion proof equipment.

            � Collect recoverable product into labelled containers for recycling.

            � Absorb remaining product with sand, earth or vermiculite.

            � Collect solid residues and seal in labelled drums for disposal.

            � Wash area and prevent runoff into drains.

            � If contamination of drains or waterways occurs, advise emergency services.



PROTECTIVE ACTIONS FOR SPILL

                           PROTECTIVE ACTION ZONE



                                                            half

                                    evacuation

                                                            downwind

                                    direction

                                                            distance

                            down wind distance

wind           isolation

               distance

direction

                                                            half

                                    evacuation              downwind

  INITIAL                           direction               distance

  ISOLATION

  ZONE



From IERG (Canada/Australia)

Isolation Distance                    25 metres

Downwind Protection Distance          300 metres

IERG Number                           14



FOOTNOTES

1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk

  of harmful exposure. This zone assumes that random changes in wind direction

  confines the vapour plume to an area within 30 degrees on either side of the

  predominant wind direction, resulting in a crosswind protective action distance

  equal to the downwind protective action distance.

2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with

  those closest to the spill and working away from the site in the downwind

  direction. Within the protective action zone a level of vapour concentration

  may exist resulting in nearly all unprotected persons becoming incapacitated

  and unable to take protective action and/or incurring serious or irreversible

  health effects.

3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the

  incident, within which a high probability of localised wind reversal may

  expose nearly all persons without appropriate protection to life-threatening

  concentrations of the material.

4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less,

  such as a drum (jerrican or box with inner containers). Larger packages leaking

  less than 200 litres and compressed gas leaking from a small cylinder are also

  considered "small spills".

  LARGE SPILLS involve many small leaking packages or a leaking package of

  greater than 200 litres, such as a cargo tank, portable tank or a "one-tonne"

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                                                                    Section 6 - ACCIDENTAL RELEASE MEASURES



     compressed gas cylinder.

5    Guide 127 is taken from the US DOT emergency response guide book.

6    IERG information is derived from CANUTEC - Transport Canada.



EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)

The maximum airborne concentration below which it is believed that nearly all

individuals could be exposed for up to one hour WITHOUT experiencing or developing



    life-threatening health effects is:

        methyl isobutyl ketone          500 ppm



    irreversible or other serious effects or symptoms which could

    impair an individual's ability to take protective action is:

       methyl isobutyl ketone           250 ppm



    other than mild, transient adverse effects

    without perceiving a clearly defined odour is:

       methyl isobutyl ketone         75 ppm



    The threshold concentration below which most people.

    will experience no appreciable risk of health effects:

       methyl isobutyl ketone        75 ppm



American Industrial Hygiene Association (AIHA)



Ingredients considered according to the following cutoffs

   Very Toxic (T+)     >= 0.1%                Toxic (T)          >= 3.0%

   R50                 >= 0.25%               Corrosive (C)      >= 5.0%

   R51                 >= 2.5%

else                   >= 10%

where percentage is percentage of ingredient found in the mixture



SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS

___________________________________________







  +     X      X       X      X       +

___________________________________________

+: May be stored together

O: May be stored together with specific preventions

X: Must not be stored together





             Personal Protective Equipment advice is contained in Section 8 of the MSDS.





             Section 7 - HANDLING AND STORAGE





PROCEDURE FOR HANDLING

       DO NOT allow clothing wet with material to stay in contact with skin.

       � Avoid all personal contact, including inhalation.

       � Wear protective clothing when risk of exposure occurs.

       � Use in a well-ventilated area.

       � Prevent concentration in hollows and sumps.

       � DO NOT enter confined spaces until atmosphere has been checked.

       � Avoid smoking, naked lights, heat or ignition sources.

       � When handling, DO NOT eat, drink or smoke.

       � Vapour may ignite on pumping or pouring due to static electricity.

       � DO NOT use plastic buckets.

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                                                                           Section 7 - HANDLING AND STORAGE



           � Earth and secure metal containers when dispensing or pouring product.

           � Use spark-free tools when handling.

           � Avoid contact with incompatible materials.

           � Keep containers securely sealed.

           � Avoid physical damage to containers.

           � Always wash hands with soap and water after handling.

           � Work clothes should be laundered separately.

           � Use good occupational work practice.

           � Observe manufacturer's storing and handling recommendations.

           � Atmosphere should be regularly checked against established exposure standards

           to ensure safe working conditions.

           The substance accumulates peroxides which may become hazardous only if it

           evaporates or is distilled or otherwise treated to concentrate the peroxides.

           The substance may concentrate around the container opening for example.

           Purchases of peroxidisable chemicals should be restricted to ensure that the

           chemical is used completely before it can become peroxidised.

           � A responsible person should maintain an inventory of peroxidisable chemicals

           or annotate the general chemical inventory to indicate which chemicals are

           subject to peroxidation. An expiration date should be determined. The chemical

           should either be treated to remove peroxides or disposed of before this date.

           � The person or laboratory receiving the chemical should record a receipt date

           on the bottle. The individual opening the container should add an opening date.

           � Unopened containers received from the supplier should be safe to store for 18

           months.

           � Opened containers should not be stored for more than 12 months.



SUITABLE CONTAINER

         Packing as supplied by manufacturer. Plastic containers may only be used if

         approved for flammable liquid. Check that containers are clearly labelled and

         free from leaks.

         � For low viscosity materials (i) : Drums and jerry cans must be of the

         non-removable head type. (ii) : Where a can is to be used as an inner package,

         the can must have a screwed enclosure.

         � For materials with a viscosity of at least 2680 cSt. (23 deg. C)

         � For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)

         � Manufactured product that requires stirring before use and having a viscosity

         of at least 20 cSt (25 deg. C)

         (i) : Removable head packaging;

         (ii) : Cans with friction closures and

         (iii) : low pressure tubes and cartridges may be used.

         � Where combination packages are used, and the inner packages are of glass,

         there must be sufficient inert cushioning material in contact with inner and

         outer packages

         � In addition, where inner packagings are glass and contain liquids of packing

         group I there must be sufficient inert absorbent to absorb any spillage, unless

         the outer packaging is a close fitting moulded plastic box and the substances

         are not incompatible with the plastic.



STORAGE INCOMPATIBILITY

        Avoid reaction with oxidising agents.

        WARNING: Long standing in contact with air and light may result in the formation

        of potentially explosive peroxides.



STORAGE REQUIREMENTS

        � Store in original containers in approved flame-proof area.

        � No smoking, naked lights, heat or ignition sources.

        � DO NOT store in pits, depressions, basements or areas where vapours may be

        trapped.

        � Keep containers securely sealed.

        � Store away from incompatible materials in a cool, dry well ventilated area.

        � Protect containers against physical damage and check regularly for leaks.

                                 METHYL ISOBUTYL KETONE

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                                                                              Section 7 - HANDLING AND STORAGE



             � Observe manufacturer's storing and handling recommendations.





             Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION





EXPOSURE CONTROLS

Source                            Material              TWA        TWA        STEL     STEL      Peak     Peak

                                                        ppm        mg/m³      ppm      m5/m³     ppm      mg/m³

_________________________         ________________      _____      _____      _____    _____     _____    _____

Australia Exposure                methyl isobutyl       50         205        75       307

Standards                         ketone





     EMERGENCY EXPOSURE LIMITS

Material               Original IDLH               Original IDLH       Revised IDLH Value         Revised IDLH Value

                       Value (ppm)                 Value (mg/m3)       (mg/m3)                    (ppm)

methyl isobutyl ketone 3,000                                                                      500



Unfatigued, odour recognition threshold (100% test panel) is 0.3 - 0.5 ppm.

Distinct odour at 15 ppm.

Odour is objectionable and vapours are irritating to eyes at 200 ppm.

NOTE: Detector tubes for methyl isobutyl ketone, measuring in excess of

50 ppm, are commercially available.

Exposure at or below the recommended TLV-TWA should provide sufficient

protection against the potential irritant effects, headache and nausea,

neurasthemic symptoms and other systemic toxicities (including liver and

kidney damage) produced by MIBK.



      ODOUR SAFETY FACTOR (OSF)

     OSF=29 (METHYL ISOBUTYL KETONE)

     Exposed individuals are reasonably expected to be warned, by smell, that the

     Exposure Standard is being exceeded.

     Odour Safety Factor (OSF) is determined to fall into either Class A or B.

     The Odour Safety Factor (OSF) is defined as:

     OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm

     Classification into classes follows:



     Class       OSF         Description

     A           550         Over 90% of exposed

                             individuals are aware by

                             smell that the Exposure

                             Standard (TLV-TWA for

                             example) is being

                             "reached " even when

                             distracted by working

                             activities

     B           26-550      As """A""" for 50-90% of

                             persons being distracted

     C           1-26        As """A""" for less than

                             50% of persons being

                             distracted

     D           0.18-1      10-50% of persons aware

                             of being tested perceive

                             by smell that the

                             Exposure Standard is

                             being reached

     E           <0.18       As """D""" for less than

                             10% of persons aware of

                             being tested

                                   METHYL ISOBUTYL KETONE

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                                            Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION



    .



      REPRODUCTIVE HEALTH GUIDELINES

    Established occupational exposure limits frequently do not take into

    consideration reproductive end points that are clearly below the thresholds for

    other toxic effects. Occupational reproductive guidelines (ORGs) have been

    suggested as an additional standard. These have been established after a

    literature search for the reproductive no-observed-adverse effect-level (NOAEL)

    and the lowest-observed-adverse-effect-level (LOAEL). In addition the US EPA's

    procedures for risk assessment for hazard identification and dose-response

    assessment as applied by NIOSH were used in the creation of such limits.



                                                                                                 TLV

Ingredient                  ORG                    UF           Endpoint        CR               Adeq

methyl isobutyl keto        205 mg/m³              NA           NA              NA               Yes

     These exposure guidelines have been derived from a screening level of risk

     assessment and should not be construed as unequivocally safe limits. ORGS

     represent an 8-hour time-weighted average unless specified otherwise.

     CR = Cancer Risk/10000; UF = Uncertainty factor:

     TLV believed to be adequate to protect reproductive health:

     LOD: Limit of detection

     Toxic endpoints have also been identified as:

     D = Developmental; R = Reproductive; TC = Transplacental carcinogen

     Jankovic J., Drake F.: A Screening Method for Occupational Reproductive

     American Industrial Hygiene Association Journal 57: 641-649 (1996).



PERSONAL PROTECTION









        EYE

              � Safety glasses with side shields.

              � Chemical goggles.

              � Contact lenses may pose a special hazard; soft contact lenses may absorb and

              concentrate irritants. A written policy document, describing the wearing of lens

              or restrictions on use, should be created for each workplace or task. This

              should include a review of lens absorption and adsorption for the class of

              chemicals in use and an account of injury experience. Medical and first-aid

              personnel should be trained in their removal and suitable equipment should be

              readily available. In the event of chemical exposure, begin eye irrigation

              immediately and remove contact lens as soon as practicable. Lens should be

              removed at the first signs of eye redness or irritation - lens should be removed

              in a clean environment only after workers have washed hands thoroughly. [CDC

              NIOSH Current Intelligence Bulletin 59].



        HANDS/FEET

            Wear chemical protective gloves, eg. PVC.

            Wear safety footwear or safety gumboots, eg. Rubber.



        OTHER

            � Overalls.

            � PVC Apron.

            � PVC protective suit may be required if exposure severe.

            � Eyewash unit.

            � Ensure there is ready access to a safety shower.

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                                            Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION



     GLOVE SELECTION INDEX

         Glove selection is based on a modified presentation of the:

         "Forsberg Clothing Performance Index".

         The effect(s) of the following substance(s) are taken into account in the

         computer-generated selection: methyl isobutyl ketone



           Protective Material CPI *.

           ________________________________

              BUTYL/NEOPRENE                 A

              PE/EVAL/PE                     A

              PVA                            A

              TEFLON                         A

              BUTYL                          B

              NATURAL RUBBER                 C

              NEOPRENE                       C

              NITRILE+PVC                    C

              PVC                            C

              NATURAL+NEOPRENE               C

              NITRILE                        C

           ________________________________

           * CPI - Chemwatch Performance Index

           A: Best Selection

           B: Satisfactory; may degrade after 4 hours continuous immersion

           C: Poor to Dangerous Choice for other than short term immersion

           NOTE: As a series of factors will influence the actual performance of the glove,

           a final selection must be based on detailed observation. -

           * Where the glove is to be used on a short term, casual or infrequent basis,

           factors such as "feel" or convenience (e.g. disposability), may dictate a choice

           of gloves which might otherwise be unsuitable following long-term or frequent

           use. A qualified practitioner should be consulted.



     RESPIRATOR

         Selection of the Class and Type of respirator will depend upon the level of

         breathing zone contaminant and the chemical nature of the contaminant.

         Protection Factors (defined as the ratio of contaminant outside and inside the

         mask) may also be important.



           Breathing Zone         Maximum                      Half-face      Full-Face

           Level ppm              Protection Factor            Respirator     Respirator

           (volume)

           1000                   10                           A-AUS          -

           1000                   50                           -              A-AUS

           5000                   50                           Airline *      -

           5000                   100                          -              A-2

           10000                  100                          -              A-3

                                  100+                                        Airline**



           * - Continuous Flow ** - Continuous-flow or positive pressure demand.



           The local concentration of material, quantity and

           conditions of use determine the type of personal

           protective equipment required.

           For further information consult site specific

           CHEMWATCH data (if available), or your

           Occupational Health and Safety Advisor.



ENGINEERING CONTROLS

        For flammable liquids and flammable gases, local exhaust ventilation or a

        process enclosure ventilation system may be required. Ventilation equipment

        should be explosion-resistant.

        Air contaminants generated in the workplace possess varying "escape" velocities

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                                            Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION



           which, in turn, determine the "capture velocities" of fresh circulating air

           required to effectively remove the contaminant.



           Type of Contaminant:                                    Air Speed:

           solvent " "vapours " degreasing "etc.                   0.25-0.5 m/s (50-100 f/min.)

           " evaporating from tank (in still

           air).

           aerosols " fumes from pouring                           0.5-1 m/s (100-200 f/min.)

           "operations " intermittent container

           "filling " low speed conveyer

           "transfers " "welding " spray "drift "

           plating acid "fumes " pickling

           (released at low velocity into zone of

           active generation)

           direct "spray " spray painting in                       1-2.5 m/s (200-500 f/min.)

           shallow "booths " drum "filling "

           conveyer "loading " crusher "dusts "

           gas discharge (active generation into

           zone of rapid air motion)



           Within each range the appropriate value depends on:



           Lower end of the range                                 Upper end of the range

           1: Room air currents minimal or                        1: Disturbing room air currents

           favourable to capture

           2: Contaminants of low toxicity or of                  2: Contaminants of high toxicity

           nuisance value only.

           3: Intermittent, low production.                       3: High production, heavy use

           4: Large hood or large air mass in                     4: Small hood-local control only

           motion



           Simple theory shows that air velocity falls rapidly with distance away from the

           opening of a simple extraction pipe. Velocity generally decreases with the

           square of distance from the extraction point (in simple cases). Therefore the

           air speed at the extraction point should be adjusted, accordingly, after

           reference to distance from the contaminating source. The air velocity at the

           extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min.) for

           extraction of solvents generated in a tank 2 meters distant from the extraction

           point. Other mechanical considerations, producing performance deficits within

           the extraction apparatus, make it essential that theoretical air velocities are

           multiplied by factors of 10 or more when extraction systems are installed or

           used.





           Section 9 - PHYSICAL AND CHEMICAL PROPERTIES





APPEARANCE

        Clear colourless, highly flammable liquid with sharp, mint-like odour;

        part mixes with water.        Mixes with alcohol, ether, acetone, and most

        organic solvents



PHYSICAL PROPERTIES

Liquid.



Molecular Weight: 100.16                                  Boiling Range (°C): 116.8

Melting Range (°C): -84.7                                 Specific Gravity (water=1): 0.80

Solubility in water (g/L): 2.0%           Miscible        pH (as supplied): Not applicable

pH (1% solution): Not applicable                          Vapour Pressure (kPa): 0.8 @ 20 deg C

Volatile Component (%vol): 100                            Evaporation Rate: 1.62 (BuAc=1)

Relative Vapour Density (air=1): 3.5                      Flash Point (°C): 17.8

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                                                            Section 9 - PHYSICAL AND CHEMICAL PROPERTIES



Lower Explosive Limit (%): 1.2                          Upper Explosive Limit (%): 8.0

Autoignition Temp (°C): 449                             Decomposition Temp (°C): Not Available

State: Liquid                                           Viscosity: Not Available





            Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION





CONDITIONS CONTRIBUTING TO INSTABILITY

         � Presence of incompatible materials.

         � Product is considered stable.

         � Hazardous polymerisation will not occur.





            Section 11 - TOXICOLOGICAL INFORMATION





POTENTIAL HEALTH EFFECTS



ACUTE HEALTH EFFECTS



     SWALLOWED

         Swallowing of the liquid may cause aspiration into the lungs with the risk of

         chemical pneumonitis; serious consequences may result. (ICSC13733).

         The material is not thought to produce adverse health effects following

         ingestion (as classified by EC Directives using animal models). Nevertheless,

         adverse systemic effects have been produced following exposure of animals by at

         least one other route and good hygiene practice requires that exposure be kept

         to a minimum.

         Accidental ingestion of the material may be damaging to the health of the

         individual.

         Considered an unlikely route of entry in commercial/industrial environments. The

         liquid may produce gastrointestinal discomfort and may be harmful if swallowed.

         Ingestion may result in nausea, pain and vomiting. Vomit entering the lungs by

         aspiration may cause potentially lethal chemical pneumonitis.



     EYE

            There is evidence that material may produce eye irritation in some persons and

            produce eye damage 24 hours or more after instillation. Severe inflammation may

            be expected with pain. There may be damage to the cornea. Unless treatment is

            prompt and adequate there may be permanent loss of vision. Conjunctivitis can

            occur following repeated exposure.

            Although the liquid is not thought to be an irritant (as classified by EC

            Directives), direct contact with the eye may produce transient discomfort

            characterised by tearing or conjunctival redness (as with windburn).



     SKIN

            There is some evidence to suggest that the material may cause mild but

            significant inflammation of the skin either following direct contact or after a

            delay of some time. Repeated exposure can cause contact dermatitis which is

            characterised by redness, swelling and blistering.

            Skin contact is not thought to produce harmful health effects (as classified

            under EC Directives using animal models). Systemic harm, however, has been

            identified following exposure of animals by at least one other route and the

            material may still produce health damage following entry through wounds, lesions

            or abrasions. Good hygiene practice requires that exposure be kept to a minimum

            and that suitable gloves be used in an occupational setting.

            Entry into the blood-stream, through, for example, cuts, abrasions or lesions,

            may produce systemic injury with harmful effects. Examine the skin prior to the

            use of the material and ensure that any external damage is suitably protected.

            The material may cause skin irritation after prolonged or repeated exposure and

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                                                                   Section 11 - TOXICOLOGICAL INFORMATION



          may produce on contact skin redness, swelling, the production of vesicles,

          scaling and thickening of the skin.

          Skin contact with the material may damage the health of the individual; systemic

          effects may result following absorption.

          The liquid may be miscible with fats or oils and may degrease the skin,

          producing a skin reaction described as non-allergic contact dermatitis. The

          material is unlikely to produce an irritant dermatitis as described in EC

          Directives .

          Repeated exposure may cause skin cracking, flaking or drying following normal

          handling and use.



     INHALED

         Inhalation of vapours or aerosols (mists, fumes), generated by the material

         during the course of normal handling, may be harmful.

         The material can cause respiratory irritation in some persons. The body's

         response to such irritation can cause further lung damage.

         Inhalation of vapours may cause drowsiness and dizziness. This may be

         accompanied by sleepiness, reduced alertness, loss of reflexes, lack of

         co-ordination, and vertigo.

         Ketone vapours irritate the nose, throat and mucous membrane. High

         concentrations depress the central nervous system, causing headache, vertigo,

         poor concentration, sleep and failure of the heart and breathing. Some ketones

         can cause multiple nerve disorders, inducing "pins and needles" and weakness in

         the limbs.

         Inhalation of vapours or aerosols (mists, fumes), generated by the material

         during the course of normal handling, may be damaging to the health of the

         individual.

         There is some evidence to suggest that the material can cause respiratory

         irritation in some persons. The body's response to such irritation can cause

         further lung damage.

         Inhalation of high concentrations of gas/vapour causes lung irritation with

         coughing and nausea, central nervous depression with headache and dizziness,

         slowing of reflexes, fatigue and inco-ordination.

         Central nervous system (CNS) depression may include general discomfort, symptoms

         of giddiness, headache, dizziness, nausea, anaesthetic effects, slowed reaction

         time, slurred speech and may progress to unconsciousness. Serious poisonings may

         result in respiratory depression and may be fatal.

         If exposure to highly concentrated solvent atmosphere is prolonged this may lead

         to narcosis, unconsciousness, even coma and possible death.



     CHRONIC HEALTH EFFECTS

         Asthma-like symptoms may continue for months or even years after exposure to the

         material ceases. This may be due to a non-allergenic condition known as reactive

         airways dysfunction syndrome (RADS) which can occur following exposure to high

         levels of highly irritating compound. Key criteria for the diagnosis of RADS

         include the absence of preceding respiratory disease, in a non-atopic

         individual, with abrupt onset of persistent asthma-like symptoms within minutes

         to hours of a documented exposure to the irritant. A reversible airflow pattern,

         on spirometry, with the presence of moderate to severe bronchial hyperreactivity

         on methacholine challenge testing and the lack of minimal lymphocytic

         inflammation, without eosinophilia, have also been included in the criteria for

         diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an

         infrequent disorder with rates related to the concentration of and duration of

         exposure to the irritating substance. Industrial bronchitis, on the other hand,

         is a disorder that occurs as result of exposure due to high concentrations of

         irritating substance (often particulate in nature) and is completely reversible

         after exposure ceases. The disorder is characterised by dyspnea, cough and

         mucous production. Substance accumulation, in the human body, may occur and may

         cause some concern following repeated or long-term occupational exposure.

         Chronic solvent inhalation exposures may result in nervous system impairment and

         liver and blood changes. [PATTYS].

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                                                                      Section 11 - TOXICOLOGICAL INFORMATION



TOXICITY AND IRRITATION

TOXICITY                                                          IRRITATION

Oral (rat) LD50: 2080 mg/kg                                       Eye (human): 200 ppm/15m

Oral (rat) LD50: 2460 mg/kg                                       Skin (rabbit): 500 mg/24h - Mild

Eye (rabbit): 40 mg - SEVERE

Eye (rabbit): 500 mg/24h - Mild





           Section 12 - ECOLOGICAL INFORMATION



           "Hazardous Air Pollutant:" Yes

           "Fish LC50 (96hr.) (mg/l):" 460 (24hr)

           "Algae IC50 (72hr.) (mg/l):" 136-725

           "log Kow (Sangster 1997):" 1.31

           BOD5: 2.06 (4.4%

           COD: 2.16 (79%)

           ThOD: 2.72

           "Half-life Soil - High (hours):" 168024

           "Half-life Soil - Low (hours):" 45.5

           "Half-life Air - High (hours):" 4.6

           "Half-life Air - Low (hours):" 468

           "Half-life Surface water - High (hours):" 24

           "Half-life Surface water - Low (hours):" 336

           "Half-life Ground water - High (hours):" 48

           "Half-life Ground water - Low (hours):" 168

           "Aqueous biodegradation - Aerobic - High (hours):" 24

           "Aqueous biodegradation - Aerobic - Low (hours):" 672

           "Aqueous biodegradation - Anaerobic - High (hours):" 96

           "Aqueous biodegradation - Anaerobic - Low (hours):" 22%

           "Photolysis maximum light absorption - High (nano-m):" 283

           "Photolysis maximum light absorption - Low (nano-m):" 232

           "Photooxidation half-life air - High (hours):" 45.5

           "Photooxidation half-life air - Low (hours):" 4.6



           DO NOT discharge into sewer or waterways.

           Drinking Water Standards:

           hydrocarbon total: 10 ug/l (UK max.).

           log Kow: 1.19-1.31

           Koc: 19-106

           Half-life (hr) air: 15-17

           Half-life (hr) H2O surface water: 15-33

           Henry's atm m³ /mol: 9.40E-05

           BOD 5 if unstated: 0.12-2.14,4.4%

           COD: 2.16,79%

           ThOD: 2.72

           BCF: 2-5

           Toxicity invertebrate: cell mult. inhib.115-980mg/L

           Bioaccumulation: not sig

           Effects on algae and plankton: cell mult. inhib. algae 90-125mg/L

           Degradation Biological: sig

           processes Abiotic: RxnOH*,photol, no hydrol&oxid





           Section 13 - DISPOSAL CONSIDERATIONS



           � Recycle wherever possible.

           � Consult manufacturer for recycling options or consult local or regional waste

           management authority for disposal if no suitable treatment or disposal facility

           can be identified.

           � Dispose of by: Burial in a licenced land-fill or Incineration in a licenced

           apparatus (after admixture with suitable combustible material)

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                                                                         Section 13 - DISPOSAL CONSIDERATIONS



           � Decontaminate empty containers. Observe all label safeguards until containers

           are cleaned and destroyed.

           If container can not be cleaned sufficiently well to ensure none of the original

           product remains or if the container cannot be used to store the same product,

           then puncture containers, to prevent re-use, and bury at an authorised landfill.





           Section 14 - TRANSPORTATION INFORMATION









Labels Required

          flammable liquid



HAZCHEM

           3[Y]E



Land Transport UNDG:

          Dangerous Goods Class:          3                         Subrisk:                            None

          UN Number:                      1245                      Packing Group:                      II

          Shipping Name:METHYL ISOBUTYL KETONE

          Edit



Air Transport IATA:

           ICAO/IATA Class:                      3                  ICAO/IATA Subrisk:                  None

           UN/ID Number:                         1245               Packing Group:                      II

           ERG Code:                             3L

           Shipping Name: Methyl isobutyl ketone



Maritime Transport IMDG:

           IMDG Class:                     3                        IMDG Subrisk:                       None

           UN Number:                      1245                     Packing Group:                      II

           EMS Number:                     None

           Shipping Name: METHYL ISOBUTYL KETONE





           Section 15 - REGULATORY INFORMATION





POISONS SCHEDULE

         AS5 NZS4



REGULATIONS



           methyl isobutyl ketone (CAS: 108-10-1) is found on the following regulatory

           lists;

           Australia Inventory of Chemical Substances (AICS)

           Australia Poisons Schedule

           OECD Representative List of High Production Volume (HPV) Chemicals

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          Section 16 - OTHER INFORMATION





          This document is copyright. Apart from any fair dealing for the purposes of

          private study, research, review or criticism, as permitted under the Copyright

          Act, no part may be reproduced by any process without written permission from

          CHEMWATCH. TEL (+61 3) 9572 4700.



          Issue Date: 5-Jan-2006

          Print Date: 29-Jun-2006