METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 1 of 15
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
METHYLENE CHLORIDE
SYNONYMS
C-H2-Cl2, dichloromethane, "methylene bichloride", "methylene dichloride",
"methane dichloride"
PROPER SHIPPING NAME
DICHLOROMETHANE
Edit
PRODUCT USE
Solvent for cellulose acetate, plastics and fats. Component of degreasing
agents, cleaning fluids and paint removers. A blowing agent in foams, as an
aerosol propellant, and a cooling solvent. The use of a quantity of material in
an unventilated or confined space may result in increased exposure and an
irritating atmosphere developing. Before starting consider control of exposure
by mechanical ventilation.
SUPPLIER
Quantum Chemicals Pty Ltd
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 2 of 15
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the
Criteria of NOHSC, and the ADG Code.
POISONS SCHEDULE
S5, NZS3
RISK
Harmful if swallowed.
Irritating to skin.
Limited evidence of a carcinogenic effect.
Inhalation and/or skin contact may produce health damage*.
Cumulative effects may result following exposure*.
May produce discomfort of the respiratory system*.
May affect fertility*.
Vapours potentially cause drowsiness and dizziness*.
* (limited evidence).
SAFETY
Keep container in a well ventilated place.
Avoid exposure - obtain special instructions before use.
Keep container tightly closed.
Take off immediately all contaminated clothing.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
methylene chloride 75-09-2 > 99
Section 4 - FIRST AID MEASURES
SWALLOWED
If poisoning occurs, contact a doctor or Poisons Information Centre.
鈥? If swallowed do NOT induce vomiting.
鈥? If vomiting occurs, lean patient forward or place on left side (head-down
position, if possible) to maintain open airway and prevent aspiration.
鈥? Observe the patient carefully.
鈥? Never give liquid to a person showing signs of being sleepy or with reduced
awareness; i.e. becoming unconscious
鈥? Give water to rinse out mouth, then provide liquid slowly and as much as
casualty can comfortably drink.
鈥? Seek medical advice.
Avoid giving milk or oils.
Avoid giving alcohol.
EYE
If this product comes in contact with the eyes:
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 3 of 15
Section 4 - FIRST AID MEASURES
鈥? Immediately hold eyelids apart and flush the eye continuously with running
water.
鈥? Ensure complete irrigation of the eye by keeping eyelids apart and away from
eye and moving the eyelids by occasionally lifting the upper and lower lids.
鈥? Continue flushing until advised to stop by the Poisons Information Centre or a
doctor, or for at least 15 minutes.
鈥? Transport to hospital or doctor without delay.
鈥? Removal of contact lenses after an eye injury should only be undertaken by
skilled personnel.
SKIN
If skin contact occurs:
鈥? Immediately remove all contaminated clothing, including footwear
鈥? Flush skin and hair with running water (and soap if available).
鈥? Seek medical attention in event of irritation.
INHALED
鈥? If fumes or combustion products are inhaled remove from contaminated area.
鈥? Lay patient down. Keep warm and rested.
鈥? Prostheses such as false teeth, which may block airway, should be removed,
where possible, prior to initiating first aid procedures.
鈥? Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if
necessary.
鈥? Transport to hospital, or doctor.
NOTES TO PHYSICIAN
Treat symptomatically.
DO NOT administer sympathomimetic drugs as they may cause ventricular
arrhythmias.
For acute or short term repeated exposures to methylene chloride:
鈥? Methylene chloride is well absorbed by the lung. An 8 hour exposure to 250 ppm
causes carboxyhaemoglobin levels to exceed 8%. Physical exertion and smoke
produce an additive effect.
鈥? The lungs exhale most of the absorbed dose unchanged. Between 1/4 and 1/3 is
metabolised to carbon monoxide / dioxide. 5 hours of 100% oxygen is required,
typically, to reduce the carboxyhaemoglobin level from 13% to 7.5%.
鈥? As with inhalation and ingestion of the hydrocarbons support of respiration
and monitoring for dysrhythmias are the first steps toward stabilisation.
鈥? Small ingestions require only dilution with water or milk. Patients who have
ingested more than several swallows may benefit from Ipecac Syrup/lavage,
charcoal or cathartics. No data is available to support the efficacy of these
treatments.
[Ellenhorn and Barceloux: Medical Toxicology]
BIOLOGICAL EXPOSURE INDEX - BEI
Determinant Index Sampling Time Comments
1. Methaemoglobin 1.5% of During or end of B, NS, SQ
in blood haemoglobin shift
B: Background levels occur in specimens collected from subjects NOT exposed.
NS: Non-specific determinant; Also seen after exposure to other materials
SQ: Semi-quantitative determinant - Interpretation may be ambiguous; should be
used as a screening test or confirmatory test.
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 4 of 15
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
Water spray or fog.
Foam.
Dry chemical powder.
Carbon dioxide.
FIRE FIGHTING
Alert Fire Brigade and tell them location and nature of hazard.
鈥? Wear breathing apparatus plus protective gloves.
鈥? Prevent, by any means available, spillage from entering drains or water
courses.
Use water delivered as a fine spray to control the fire and cool adjacent area.
Cool fire exposed containers with water spray from a protected location.
DO NOT approach containers suspected to be hot.
If safe to do so, remove containers from path of fire.
Fight fire from a safe distance, with adequate cover.
FIRE/EXPLOSION HAZARD
鈥? Non flammable liquid.
鈥? However vapour will burn when in contact with high temperature flame.
鈥? Ignition ceases on removal of flame.
鈥? May form a flammable / explosive mixture in an oxygen enriched atmosphere
鈥? Heating may cause expansion/vapourisation with violent rupture of containers
鈥? Decomposes on heating and produces corrosive fumes of hydrochloric acid,
carbon monoxide and small amounts of toxic phosgene.
FIRE INCOMPATIBILITY
Avoid contact with strong acids strong alkalis and strong oxidisers.
May react violently with.
aluminium and magnesium powdered metals and alkali metals e.g. sodium,
potassium, lithium.
Dissolves most plastics and synthetic fibres.
HAZCHEM
2Z
Personal Protective Equipment
Breathing apparatus.
Chemical splash suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Clean up all spills immediately.
Avoid breathing vapours and contact with skin and eyes.
Wear protective clothing, impervious gloves and safety glasses.
Wipe up and absorb small quantities with vermiculite or other absorbent
material.
Place spilled material in clean, dry, sealable, labelled container.
MAJOR SPILLS
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
鈥? Wear breathing apparatus plus protective gloves.
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 5 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
鈥? Prevent, by any means available, spillage from entering drains or water
courses.
Shut off all possible sources of ignition and increase ventilation.
Stop leak if safe to do so.
Contain spill with sand, earth or vermiculite.
Use only spark-free shovels and explosion proof equipment.
Reclaim solvent for recycling at an approved site.
Absorb remaining product with sand, earth or vermiculite.
Collect residues and seal in labelled drums for disposal.
Wash spill area with detergent and water.
After clean up operations, decontaminate and launder all protective clothing and
equipment before storing and re-using.
If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance 25 metres
Downwind Protection Distance 250 metres
IERG Number 37
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk
of harmful exposure. This zone assumes that random changes in wind direction
confines the vapour plume to an area within 30 degrees on either side of the
predominant wind direction, resulting in a crosswind protective action distance
equal to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with
those closest to the spill and working away from the site in the downwind
direction. Within the protective action zone a level of vapour concentration
may exist resulting in nearly all unprotected persons becoming incapacitated
and unable to take protective action and/or incurring serious or irreversible
health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the
incident, within which a high probability of localised wind reversal may
expose nearly all persons without appropriate protection to life-threatening
concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less,
such as a drum (jerrican or box with inner containers). Larger packages leaking
less than 200 litres and compressed gas leaking from a small cylinder are also
considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of
greater than 200 litres, such as a cargo tank, portable tank or a "one-tonne"
compressed gas cylinder.
5 Guide 160 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 6 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
methylene chloride 4000 ppm
irreversible or other serious effects or symptoms which could
impair an individual's ability to take protective action is:
methylene chloride 750 ppm
other than mild, transient adverse effects
without perceiving a clearly defined odour is:
methylene chloride 200 ppm
The threshold concentration below which most people.
will experience no appreciable risk of health effects:
methylene chloride 25 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ X + X 0 +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
Use good occupational work practice. Observe manufacturer's storing and handling
recommendations.
Atmosphere should be regularly checked against established exposure standards to
ensure safe working conditions are maintained.
Avoid all personal contact, including inhalation.
Avoid generating and breathing mist.
Wear protective clothing when risk of exposure occurs.
Avoid smoking, naked lights or ignition sources.
Use in a well-ventilated area.
until atmosphere has been checked.
Avoid contact with incompatible materials.
DO NOT spray directly on humans, exposed food or food utensils.
When handling, DO NOT eat, drink or smoke.
Keep containers securely sealed when not in use.
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 7 of 15
Section 7 - HANDLING AND STORAGE
Avoid physical damage to containers.
Always wash hands with soap and water after handling. Work clothes should be
laundered separately.
SUITABLE CONTAINER
Packaging as recommended by manufacturer.
鈥? Check that containers are clearly labelled.
Metal can.
Metal drum.
STORAGE INCOMPATIBILITY
Segregate from strong oxidisers strong alkalis.
aluminium and magnesium powdered metals and alkali metals e.g. sodium,
potassium, lithium.
Segregate from alcohol, water.
In the presence of moisture and at higher temperatures material breaks
down generating hydrochloric acid, which may corrode and perforate
containers.
STORAGE REQUIREMENTS
Observe manufacturer's storing and handling recommendations.
Store in original containers.
Keep containers securely sealed.
Store in a cool, dry and well-ventilated area.
Store away from incompatible materials.
Store away from foodstuff containers.
DO NOT store in pits, depressions, basements or areas where vapours may be
trapped.
Protect containers against physical damage.
Check regularly for spills and leaks.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak
ppm mg/m鲁 ppm m5/m鲁 ppm mg/m鲁
_________________________ ________________ _____ _____ _____ _____ _____ _____
Australia Exposure methylene 50 174
Standards chloride
EMERGENCY EXPOSURE LIMITS
Material Original IDLH Original IDLH Revised IDLH Value Revised IDLH Value
Value (ppm) Value (mg/m3) (mg/m3) (ppm)
methylene chloride 10,000 2,000
Odour Threshold Value: 158 ppm (detection), 227 ppm (recognition)
NOTE: Detector tubes for methylene chloride, measuring in excess of 25 ppm
are commercially available. Long-term measurements (4 hrs) may be
conducted to detect concentrations exceeding 13 ppm.
Exposure at or below the recommended TLV-TWA (and in the absence of
occupational exposure to carbon monoxide) is thought to minimise the
potential for liver injury and to provide protection against the possible
weak carcinogenic effects which have been demonstrated in laboratory rats
and mice. Enhancement of tumours of the lung, liver, salivary glands and
mammary tissue in rodent studies has lead NIOSH to recommend a more
conservative outcome. The ACGIH however concludes that in the absence of
documentation of health-related injuries at higher exposures after a
long history of methylene chloride use and a number of epidemiologic
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 8 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
studies, the recommended TLV-TWA provides an adequate margin of safety.
Concentration effects:
-------------------------------------------------------------------------
Concentration Clinical effects
-------------------------------------------------------------------------
>300 ppm Sweet odour
500-1000 ppm (1-2 h) Unpleasant odour, slight anaesthetic effects,
headache, light-headedness, eye irritation
and elevated COHb concentration
2300 ppm (5 min.) Odour strong, intensely irritating; dizziness
7200 ppm (8-16 min) Paraesthesia, tachycardia
>50000 ppm Immediately life-threatening
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into
consideration reproductive end points that are clearly below the thresholds for
other toxic effects. Occupational reproductive guidelines (ORGs) have been
suggested as an additional standard. These have been established after a
literature search for the reproductive no-observed-adverse effect-level (NOAEL)
and the lowest-observed-adverse-effect-level (LOAEL). In addition the US EPA's
procedures for risk assessment for hazard identification and dose-response
assessment as applied by NIOSH were used in the creation of such limits.
Uncertainty factors (UFs) have also been incorporated.
TLV
Ingredient ORG UF Endpoint CR Adeq
methylene chloride 2.4 mg/m鲁 100 R 14 -
These exposure guidelines have been derived from a screening level of risk
assessment and should not be construed as unequivocally safe limits. ORGS
represent an 8-hour time-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
PERSONAL PROTECTION
EYE
鈥? Chemical goggles.
鈥? Safety glasses with side shields.
鈥? Full face shield.
鈥? Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens
or restrictions on use, should be created for each workplace or task. This
should include a review of lens absorption and adsorption for the class of
chemicals in use and an account of injury experience. Medical and first-aid
personnel should be trained in their removal and suitable equipment should be
readily available. In the event of chemical exposure, begin eye irrigation
immediately and remove contact lens as soon as practicable. Lens should be
removed at the first signs of eye redness or irritation - lens should be removed
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 9 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
鈥? Barrier cream and PVA gloves or Viton gloves or Wear chemical protective
gloves, eg. PVC.
Wear safety footwear.
DO NOT use this product to clean the skin.
OTHER
Overalls and Plastic apron.
鈥? Impervious protective clothing.
鈥? Eyewash unit.
Ensure there is ready access to a safety shower.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
"Forsberg Clothing Performance Index".
The effect(s) of the following substance(s) are taken into account in the
computer-generated selection: methylene chloride
Protective Material CPI *.
________________________________
PE/EVAL/PE A
PVA A
TEFLON B
VITON C
VITON/BUTYL C
VITON/CHLOROBUTYL C
CPE C
BUTYL C
NATURAL RUBBER C
NEOPRENE C
________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent
use. A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of
breathing zone contaminant and the chemical nature of the contaminant.
Protection Factors (defined as the ratio of contaminant outside and inside the
mask) may also be important.
Breathing Zone Maximum Half-face Full-Face
Level ppm Protection Factor Respirator Respirator
(volume)
1000 10 AX-AUS -
1000 50 - AX-AUS
5000 50 Airline * -
5000 100 - AX-2
10000 100 - AX-3
100+ Airline**
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 10 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and
conditions of use determine the type of personal
protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Use in a well-ventilated area.
General exhaust is adequate under normal operating conditions. If risk of
overexposure exists, wear SAA approved respirator. Correct fit is essential to
obtain adequate protection. Provide adequate ventilation in warehouse or closed
storage areas. Air contaminants generated in the workplace possess varying
"escape" velocities which, in turn, determine the "capture velocities" of fresh
circulating air required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
solvent " "vapours " degreasing "etc. 0.25-0.5 m/s (50-100 f/min)
" evaporating from tank (in still air)
aerosols " fumes from pouring 0.5-1 m/s (100-200 f/min.)
"operations " intermittent container
"filling " low speed conveyer
"transfers " "welding " spray "drift "
plating acid "fumes " pickling
(released at low velocity into zone of
active generation)
direct "spray " spray painting in 1-2.5 m/s (200-500 f/min)
shallow "booths " drum "filling "
conveyer "loading " crusher "dusts "
gas discharge (active generation into
zone of rapid air motion)
grinding " abrasive "blasting " 2.5-10 m/s (500-2000 f/min.)
"tumbling " high speed wheel generated
dusts (released at high initial
velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or 1: Disturbing room air currents
favourable to capture
2: Contaminants of low toxicity or of 2: Contaminants of high toxicity
nuisance value only
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in 4: Small hood - local control only
motion
Simple theory shows that air velocity falls rapidly with distance away from the
opening of a simple extraction pipe. Velocity generally decreases with the
square of distance from the extraction point (in simple cases). Therefore the
air speed at the extraction point should be adjusted, accordingly, after
reference to distance from the contaminating source. The air velocity at the
extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min.) for
extraction of solvents generated in a tank 2 meters distant from the extraction
point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or
used.
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 11 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
In confined spaces where there is inadequate ventilation, wear full-face air
supplied breathing apparatus.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Colourless non flammable liquid; does not mix with water. Highly volatile.
Has a penetrating, ether-like odour. Mixes with alcohol, organic solvents.
PHYSICAL PROPERTIES
Liquid.
Molecular Weight: 84.93 Boiling Range (掳C): 40
Melting Range (掳C): -97 Specific Gravity (water=1): 1.32
Solubility in water (g/L): 2.0% pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): 46.5 @20C
Volatile Component (%vol): 100 Evaporation Rate: >1 BuAc=1
Relative Vapour Density (air=1): 2.93 Flash Point (掳C): Not applicable
Lower Explosive Limit (%): 14-oxygen nrich Upper Explosive Limit (%): 22-oxygen nrich
Autoignition Temp (掳C): 662 Decomposition Temp (掳C): Not available
State: Liquid Viscosity: Not available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
鈥? Presence of incompatible materials.
鈥? Product is considered stable.
鈥? Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
The liquid is highly discomforting and toxic if swallowed Ingestion may result
in nausea, abdominal irritation, pain and vomiting.
Considered an unlikely route of entry in commercial/industrial environments.
EYE
The liquid is highly discomforting to the eyes and is capable of causing pain
and severe conjunctivitis. Corneal injury may develop, with possible permanent
impairment of vision, if not promptly and adequately treated.
The vapour is discomforting to the eyes.
The material may produce moderate eye irritation leading to inflammation.
Repeated or prolonged exposure to irritants may produce conjunctivitis.
SKIN
The liquid is highly discomforting to the skin and may cause drying of the skin.
Toxic effects may result from skin absorption.
Bare unprotected skin should not be exposed to this material.
The material may accentuate any pre-existing skin condition.
The material may cause severe skin irritation after prolonged or repeated
exposure and may produce on contact skin redness, swelling, the production of
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
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Section 11 - TOXICOLOGICAL INFORMATION
vesicles, scaling and thickening of the skin. Repeated exposures may produce
severe ulceration.
INHALED
The vapour is highly discomforting to the upper respiratory tract.
Inhalation hazard is increased at higher temperatures.
At high concentrations most of the absorbed methylene chloride (dichloromethane)
is exhaled unchanged; the remainder is metabolised to carbon monoxide, carbon
dioxide and inorganic chloride. Inhalation may produce fatigue, weakness,
sleepiness, light-headedness, chills, nausea, diarrhoea and abdominal pain. The
lowest published lethal dose is 20,000 ppm for 20 hours. The body metabolises
methylene chloride to carbon monoxide and adds to the body burden of
carboxyhaemoglobin (COHb) contributed by other sources. The increase in COHb is
related to the magnitude of vapour exposure and duration. Serious poisoning can
occur without raised COHb concentrations, although these raised concentrations
may persist for several hours. Central nervous system (CNS) effects are thought
to be due to methylene chloride itself or methylene chloride in combination with
other sources of COHb, rather than the COHb metabolite. The raised COHb
concentrations are not usually expected to produce adverse effects in healthy
individuals but may be cause for concern in individuals with cardiovascular
disease. Encephalopathy (brain injury) has been reported after repeated
exposure. Angina, myocardial infarction, cardiac arrhythmias and cardiac arrest
have also been reported, although the cardiovascular system is not generally a
target for methylene chloride toxicity. Hypotension, shock and metabolic
acidosis may also occur as a result of overexposure. Respiratory failure may
develop, secondary to CNS depression, in severe cases.
Inhalation exposure may cause susceptible individuals to show change in heart
beat rhythm i.e. cardiac arrhythmia. Exposures must be terminated.
Acute intoxication by halogenated aliphatic hydrocarbons appears to take place
over two stages. Signs of a reversible narcosis are evident in the first stage
and in the second stage signs of injury to organs may become evident, a single
organ alone is (almost) never involved.
Depression of the central nervous system is the most outstanding effect of most
halogenated aliphatic hydrocarbons. Inebriation and excitation, passing into
narcosis, is a typical reaction. In severe acute exposures there is always a
danger of death from respiratory failure or cardiac arrest due to a tendency to
make the heart more susceptible to catecholamines (adrenalin).
CHRONIC HEALTH EFFECTS
Principal routes of exposure are usually by. skin contact/absorption and
inhalation of vapour. Dichloromethane is stored in body fat and metabolised to
carbon monoxide, which reduces the oxygen carrying capacity of blood.
Dichloromethane exposures cause liver and kidney damage in animals and this
justifies consideration before exposing persons with a history of impaired liver
function and/or renal disorders.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (human) LDLo: 357 mg/kg
Skin (rabbit): 810 mg/24hr-SEVERE
Skin (rabbit): 100mg/24hr-Moderate Moderate
Eye(rabbit): 162 mg - m
Eye(rabbit): 500 mg/24hr - Mild
WARNING: This substance has been classified by the IARC as Group 2B: Possibly
Carcinogenic to Humans.
MATERIAL CARCINOGEN SENSITISER SKIN REPROTOXIN
______________________________ ____________ __________ __________ __________
methylene chloride IARC:Group ILOEl
2B: Possibly
carcinogenic
to humans
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
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Section 11 - TOXICOLOGICAL INFORMATION
NTPB
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC)
Carcinogens: methylene chloride Category: Group 2B: Possibly
carcinogenic to humans
CARCINOGEN
NTPB: US National Toxicology Program (NTP) 11th Report Part B.
Reasonably Anticipated to be a Human Carcinogen: methylene
chloride Category:
REPROTOXIN
ILOEl: ILO Chemicals in the electronics industry that have toxic
effects on reproduction: methylene chloride
Section 12 - ECOLOGICAL INFORMATION
"Fish LC50 (96hr.) (mg/l):" 147.6-193
"Daphnia magna EC50 (48hr.) (mg/l):" 224
BCF<100: 5
"log Kow (Prager 1995):" 1.25
"Half-life Soil - High (hours):" 672
"Half-life Soil - Low (hours):" 168
"Half-life Air - High (hours):" 4584
"Half-life Air - Low (hours):" 458
"Half-life Surface water - High (hours):" 672
"Half-life Surface water - Low (hours):" 168
"Half-life Ground water - High (hours):" 1344
"Half-life Ground water - Low (hours):" 336
"Aqueous biodegradation - Aerobic - High (hours):" 672
"Aqueous biodegradation - Aerobic - Low (hours):" 168
"Aqueous biodegradation - Anaerobic - High (hours):" 2688
"Aqueous biodegradation - Anaerobic - Low (hours):" 672
"Aqueous biodegradation - Removal secondary treatment - High (hours):" 94.50%
"Photolysis maximum light absorption - High (nano-m):" 250
"Photolysis maximum light absorption - Low (nano-m):" 220
"Photooxidation half-life air - High (hours):" 4584
"Photooxidation half-life air - Low (hours):" 458
"First order hydrolysis half-life (hours):" 704 YR
log Kow: 1.25
log Koc: 1.68
log Kom: 1.44
Henry's atm m鲁 /mol: 2.68E-03
BCF: 5
The UK Department of Environment have established that methylene chloride is not
a greenhouse gas and the Organisation for Economic Cooperation and Development
(OECD) in a Monograph have affirmed that there was no single international view
that risk reduction measures are required for the solvent. The Monograph
suggests that alternatives may pose a greater risk to the environment.
In the atmosphere methylene chloride degrades by reaction with photochemically
produced hydroxy radicals (half-life 6 months). Methylene chloride rapidly
volatilises from water and soil to the atmosphere (estimated half-life for
volatilisation from water 3-5.6 hours). In soil methylene chloride may partially
leach to ground water. It is not expected to bioaccumulate or bioconcentrate in
the food chain.
Drinking Water Standards:
hydrocarbon total: 10 ug/l (UK max)
dichloromethane: 20 ug/l (WHO guideline)
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 14 of 15
Section 12 - ECOLOGICAL INFORMATION
Soil Guidelines: Dutch Criteria: detection threshold (target)
20 mg/kg (intervention)
Air Quality Standards:
3 mg/m3 averaging time 24 hours (WHO guideline).
Section 13 - DISPOSAL CONSIDERATIONS
Recycle wherever possible.
Consult manufacturer for recycling options.
Consult State Land Waste Management Authority for disposal.
Reclaim solvent at an approved site.
Evaporate or incinerate residue at an approved site.
Recycle containers if possible, or dispose of in an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
Labels Required
toxic
HAZCHEM
2Z
Land Transport UNDG:
Dangerous Goods Class: 6.1 Subrisk: None
UN Number: 1593 Packing Group: III
Shipping Name:DICHLOROMETHANE
Edit
Air Transport IATA:
ICAO/IATA Class: 6.1 ICAO/IATA Subrisk: None
UN/ID Number: 1593 Packing Group: III
ERG Code: 6L
Shipping Name: Dichloromethane
Maritime Transport IMDG:
IMDG Class: 6.1 IMDG Subrisk: None
UN Number: 1593 Packing Group: III
EMS Number: None
Shipping Name: DICHLOROMETHANE
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
S5, NZS3
REGULATIONS
methylene chloride (CAS: 75-09-2) is found on the following regulatory lists;
METHYLENE CHLORIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 22-Jan-2006 CHEMWATCH 1593
A317TC CD 2006/2 Page 15 of 15
Section 15 - REGULATORY INFORMATION
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia Poisons Schedule
International Agency for Research on Cancer (IARC) Carcinogens
International Council of Chemical Associations (ICCA) - High Production Volume
List
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
This document is copyright. Apart from any fair dealing for the purposes of
private study, research, review or criticism, as permitted under the Copyright
Act, no part may be reproduced by any process without written permission from
CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 22-Jan-2006
Print Date: 29-Jun-2006
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