ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 1 of 15
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
ISOPROPANOL
SYNONYMS
C3-H8-O, CH3-CH(OH)-CH3, (CH3)2-CHOH, IPA, 2-propanol, "isopropyl alcohol",
"dimethyl carbinol", "sec-propyl alcohol", "iso propyl alcohol", "isohol
petrohol", 1-methylethanol
PROPER SHIPPING NAME
ISOPROPANOL (ISOPROPYL ALCOHOL)
Edit
PRODUCT USE
Solvent for chemicals, paints, varnishes, gums, resins, essential oils. Used in
the preservation of physiological and pathological specimens. Used for
extraction processes, perfumery, and pharmaceuticals. Used in the production of
acetone, glycerol and isopropyl esters, acetate.
SUPPLIER
Quantum Chemicals Pty Ltd
70 Quantum Close
Quantum Industrial Park
Dandenong South VIC 3175
Australia
Telephone: 1300 782 688
Emergency Tel: 1300 131 001
Fax: 1300 782 699
HAZARD RATINGS
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 2 of 15
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the
Criteria of NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK
Highly flammable.
May form explosive peroxides.
Irritating to eyes.
HARMFUL-May cause lung damage if swallowed.
Vapours may cause drowsiness and dizziness.
Inhalation and/or ingestion may produce health damage*.
May produce discomfort of the respiratory system and skin*.
Limited evidence of a carcinogenic effect*.
* (limited evidence).
SAFETY
Do not breathe gas/fumes/vapour/spray.
Wear eye/face protection.
Use only in well ventilated areas.
Keep container in a well ventilated place.
Keep container tightly closed.
Take off immediately all contaminated clothing.
In case of contact with eyes, rinse with plenty of water and contact Doctor or
Poisons Information Centre.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
isopropanol 67-63-0 >99
Section 4 - FIRST AID MEASURES
SWALLOWED
鈥? For advice, contact a Poisons Information Centre or a doctor at once.
鈥? Urgent hospital treatment is likely to be needed.
鈥? If swallowed do NOT induce vomiting.
鈥? If vomiting occurs, lean patient forward or place on left side (head-down
position, if possible) to maintain open airway and prevent aspiration.
鈥? Observe the patient carefully.
鈥? Never give liquid to a person showing signs of being sleepy or with reduced
awareness; i.e. becoming unconscious.
鈥? Give water to rinse out mouth, then provide liquid slowly and as much as
casualty can comfortably drink.
鈥? Transport to hospital or doctor without delay.
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 3 of 15
Section 4 - FIRST AID MEASURES
EYE
If this product comes in contact with the eyes:
鈥? Wash out immediately with fresh running water.
鈥? Ensure complete irrigation of the eye by keeping eyelids apart and away from
eye and moving the eyelids by occasionally lifting the upper and lower lids.
鈥? If pain persists or recurs seek medical attention.
鈥? Removal of contact lenses after an eye injury should only be undertaken by
skilled personnel.
SKIN
If skin contact occurs:
鈥? Immediately remove all contaminated clothing, including footwear
鈥? Flush skin and hair with running water (and soap if available).
鈥? Seek medical attention in event of irritation.
INHALED
鈥? If fumes or combustion products are inhaled remove from contaminated area.
鈥? Lay patient down. Keep warm and rested.
鈥? Prostheses such as false teeth, which may block airway, should be removed,
where possible, prior to initiating first aid procedures.
鈥? Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if
necessary.
鈥? Transport to hospital, or doctor.
NOTES TO PHYSICIAN
For acute or short term repeated exposures to isopropanol:
鈥? Rapid onset respiratory depression and hypotension indicates serious
ingestions that require careful cardiac and respiratory monitoring together with
immediate intravenous access.
鈥? Rapid absorption precludes the usefulness of emesis or lavage 2 hours
post-ingestion. Activated charcoal and cathartics are not clinically useful.
Ipecac is most useful when given 30 mins. post-ingestion.
鈥? There are no antidotes.
鈥? Management is supportive. Treat hypotension with fluids followed by
vasopressors.
鈥? Watch closely, within the first few hours for respiratory depression; follow
arterial blood gases and tidal volumes.
鈥? Ice water lavage and serial haemoglobin levels are indicated for those
patients with evidence of gastrointestinal bleeding.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
鈥? Alcohol stable foam.
鈥? Dry chemical powder.
鈥? BCF (where regulations permit).
鈥? Carbon dioxide.
鈥? Water spray or fog - Large fires only.
FIRE FIGHTING
鈥? Alert Fire Brigade and tell them location and nature of hazard.
鈥? May be violently or explosively reactive.
鈥? Wear breathing apparatus plus protective gloves.
鈥? Prevent, by any means available, spillage from entering drains or water
course.
鈥? Consider evacuation (or protect in place).
鈥? Fight fire from a safe distance, with adequate cover.
鈥? If safe, switch off electrical equipment until vapour fire hazard removed.
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 4 of 15
Section 5 - FIRE FIGHTING MEASURES
鈥? Use water delivered as a fine spray to control the fire and cool adjacent
area.
鈥? Avoid spraying water onto liquid pools.
鈥? Do not approach containers suspected to be hot.
鈥? Cool fire exposed containers with water spray from a protected location.
鈥? If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
鈥? Liquid and vapour are highly flammable.
鈥? Severe fire hazard when exposed to heat, flame and/or oxidisers.
鈥? Vapour may travel a considerable distance to source of ignition.
鈥? Heating may cause expansion or decomposition leading to violent rupture of
containers.
鈥? On combustion, may emit toxic fumes of carbon monoxide (CO).
Combustion products include, carbon dioxide (CO2), other pyrolysis products
typical of burning organic material.
WARNING: Long standing in contact with air and light may result in the formation
of potentially explosive peroxides.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids,
chlorine bleaches, pool chlorine etc. as ignition may result.
HAZCHEM
2[Y]E
Personal Protective Equipment
Gloves, boots (chemical resistant).
Breathing apparatus.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
鈥? Remove all ignition sources.
鈥? Clean up all spills immediately.
鈥? Avoid breathing vapours and contact with skin and eyes.
鈥? Control personal contact by using protective equipment.
鈥? Contain and absorb small quantities with vermiculite or other absorbent
material.
鈥? Wipe up.
鈥? Collect residues in a flammable waste container.
MAJOR SPILLS
Chemical Class: alcohols and glycols
For release onto land: recommended sorbents listed in order of priority.
SORBENT TYPE RANK APPLICATION COLLECTION LIMITATIONS
LAND SPILL - SMALL
cross-linked 1 shovel shovel R, W, SS
polymer -
particulate
cross-linked 1 throw pitchfork R, DGC, RT
polymer -
pillow
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 5 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
sorbent clay 2 shovel shovel R,I, P
-
particulate
wood fiber - 3 throw pitchfork R " "P "
pillow "DGC " RT
treated wood 3 throw pitchfork DGC, RT
fiber -
pillow
foamed glass 4 throw pichfork R " "P "
- pillow "DGC " RT
LAND SPILL - MEDIUM
cross-linked 1 blower skiploader R,W, SS
polymer -
particulate
polypropylen 2 blower skiploader W, SS, DGC
e" -
particulate
sorbent clay 2 blower skiploader R " "I " "W
- " "P " DGC
particulate
polypropylen 3 throw skiploader DGC, RT
e" - mat
expanded 3 blower skiploader R " "I " "W
mineral - " "P " DGC
particulate
polyurethane 4 throw skiploader DGC, RT
- mat
Legend
DGC: Not effective where ground cover is dense
R; Not reusable
I: Not incinerable
P: Effectiveness reduced when rainy
RT:Not effective where terrain is rugged
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation
1988.
鈥? Clear area of personnel and move upwind.
鈥? Alert Fire Brigade and tell them location and nature of hazard.
鈥? May be violently or explosively reactive.
鈥? Wear breathing apparatus plus protective gloves.
鈥? Prevent, by any means available, spillage from entering drains or water
course.
鈥? Consider evacuation (or protect in place).
鈥? No smoking, naked lights or ignition sources.
鈥? Increase ventilation.
鈥? Stop leak if safe to do so.
鈥? Water spray or fog may be used to disperse /absorb vapour.
鈥? Contain spill with sand, earth or vermiculite.
鈥? Use only spark-free shovels and explosion proof equipment.
鈥? Collect recoverable product into labelled containers for recycling.
鈥? Absorb remaining product with sand, earth or vermiculite.
鈥? Collect solid residues and seal in labelled drums for disposal.
鈥? Wash area and prevent runoff into drains.
鈥? If contamination of drains or waterways occurs, advise emergency services.
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 6 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
PROTECTIVE ACTIONS FOR SPILL
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance 50 metres
Downwind Protection Distance 300 metres
IERG Number 16
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk
of harmful exposure. This zone assumes that random changes in wind direction
confines the vapour plume to an area within 30 degrees on either side of the
predominant wind direction, resulting in a crosswind protective action distance
equal to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with
those closest to the spill and working away from the site in the downwind
direction. Within the protective action zone a level of vapour concentration
may exist resulting in nearly all unprotected persons becoming incapacitated
and unable to take protective action and/or incurring serious or irreversible
health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the
incident, within which a high probability of localised wind reversal may
expose nearly all persons without appropriate protection to life-threatening
concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less,
such as a drum (jerrican or box with inner containers). Larger packages leaking
less than 200 litres and compressed gas leaking from a small cylinder are also
considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of
greater than 200 litres, such as a cargo tank, portable tank or a "one-tonne"
compressed gas cylinder.
5 Guide 129 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all
individuals could be exposed for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
isopropanol 2000 ppm
irreversible or other serious effects or symptoms which could
impair an individual's ability to take protective action is:
isopropanol 2000 ppm
other than mild, transient adverse effects
without perceiving a clearly defined odour is:
isopropanol 400 ppm
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 7 of 15
Section 6 - ACCIDENTAL RELEASE MEASURES
The threshold concentration below which most people.
will experience no appreciable risk of health effects:
isopropanol 400 ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
___________________________________________
+ X X X X +
___________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
鈥? Avoid all personal contact, including inhalation.
鈥? Wear protective clothing when risk of exposure occurs.
鈥? Use in a well-ventilated area.
鈥? Prevent concentration in hollows and sumps.
鈥? DO NOT enter confined spaces until atmosphere has been checked.
鈥? Avoid smoking, naked lights, heat or ignition sources.
鈥? When handling, DO NOT eat, drink or smoke.
鈥? Vapour may ignite on pumping or pouring due to static electricity.
鈥? DO NOT use plastic buckets.
鈥? Earth and secure metal containers when dispensing or pouring product.
鈥? Use spark-free tools when handling.
鈥? Avoid contact with incompatible materials.
鈥? Keep containers securely sealed.
鈥? Avoid physical damage to containers.
鈥? Always wash hands with soap and water after handling.
鈥? Work clothes should be laundered separately.
鈥? Use good occupational work practice.
鈥? Observe manufacturer's storing and handling recommendations.
鈥? Atmosphere should be regularly checked against established exposure standards
to ensure safe working conditions.
DO NOT allow clothing wet with material to stay in contact with skin.
The substance accumulates peroxides which may become hazardous only if it
evaporates or is distilled or otherwise treated to concentrate the peroxides.
The substance may concentrate around the container opening for example.
Purchases of peroxidisable chemicals should be restricted to ensure that the
chemical is used completely before it can become peroxidised.
鈥? A responsible person should maintain an inventory of peroxidisable chemicals
or annotate the general chemical inventory to indicate which chemicals are
subject to peroxidation. An expiration date should be determined. The chemical
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
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Section 7 - HANDLING AND STORAGE
should either be treated to remove peroxides or disposed of before this date.
鈥? The person or laboratory receiving the chemical should record a receipt date
on the bottle. The individual opening the container should add an opening date.
鈥? Unopened containers received from the supplier should be safe to store for 18
months.
鈥? Opened containers should not be stored for more than 12 months.
SUITABLE CONTAINER
DO NOT use aluminium or galvanised containers.
Packing as supplied by manufacturer. Plastic containers may only be used if
approved for flammable liquid. Check that containers are clearly labelled and
free from leaks.
鈥? For low viscosity materials (i) : Drums and jerry cans must be of the
non-removable head type. (ii) : Where a can is to be used as an inner package,
the can must have a screwed enclosure.
鈥? For materials with a viscosity of at least 2680 cSt. (23 deg. C)
鈥? For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
鈥? Manufactured product that requires stirring before use and having a viscosity
of at least 20 cSt (25 deg. C)
(i) : Removable head packaging;
(ii) : Cans with friction closures and
(iii) : low pressure tubes and cartridges may be used.
鈥? Where combination packages are used, and the inner packages are of glass,
there must be sufficient inert cushioning material in contact with inner and
outer packages
鈥? In addition, where inner packagings are glass and contain liquids of packing
group I there must be sufficient inert absorbent to absorb any spillage, unless
the outer packaging is a close fitting moulded plastic box and the substances
are not incompatible with the plastic.
STORAGE INCOMPATIBILITY
Avoid storage with strong acids, acid chlorides, acid anhydrides, oxidising
agents.
Incompatible with aluminium. DO NOT heat above 49 deg. C. in aluminium
equipment.
Secondary alcohols and some branched primary alcohols may produce potentially
explosive peroxides after exposure to light and/ or heat.
Avoid isocyanates.
STORAGE REQUIREMENTS
鈥? Store in original containers in approved flame-proof area.
鈥? No smoking, naked lights, heat or ignition sources.
鈥? DO NOT store in pits, depressions, basements or areas where vapours may be
trapped.
鈥? Keep containers securely sealed.
鈥? Store away from incompatible materials in a cool, dry well ventilated area.
鈥? Protect containers against physical damage and check regularly for leaks.
鈥? Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA TWA STEL STEL Peak Peak
ppm mg/m鲁 ppm m5/m鲁 ppm mg/m鲁
_________________________ ________________ _____ _____ _____ _____ _____ _____
Australia Exposure isopropanol 400 983 500 1,230
Standards
ISOPROPANOL
Chemwatch Material Safety Data Sheet
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Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EMERGENCY EXPOSURE LIMITS
Material Original IDLH Original IDLH Revised IDLH Value Revised IDLH Value
Value (ppm) Value (mg/m3) (mg/m3) (ppm)
isopropanol 12,000 2,000 [LEL]
NOTES
Values marked LEL indicate that the IDLH was based on 10% of the lower explosive
limit for safety considerations even though the relevant toxicological data
indicated that irreversible health effects or impairment of escape existed
only at higher concentrations.
Odour Threshold Value: 3.3 ppm (detection), 7.6 ppm (recognition)
Exposure at or below the recommended TLV-TWA and STEL is thought to
minimise the potential for inducing narcotic effects or significant
irritation of the eyes or upper respiratory tract. It is believed, in the
absence of hard evidence, that this limit also provides protection against
the development of chronic health effects. The limit is intermediate to
that set for ethanol, which is less toxic, and n-propyl alcohol, which is
more toxic, than isopropanol.
PERSONAL PROTECTION
EYE
鈥? Safety glasses with side shields.
鈥? Chemical goggles.
鈥? Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens
or restrictions on use, should be created for each workplace or task. This
should include a review of lens absorption and adsorption for the class of
chemicals in use and an account of injury experience. Medical and first-aid
personnel should be trained in their removal and suitable equipment should be
readily available. In the event of chemical exposure, begin eye irrigation
immediately and remove contact lens as soon as practicable. Lens should be
removed at the first signs of eye redness or irritation - lens should be removed
in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
鈥? Overalls.
鈥? PVC Apron.
鈥? PVC protective suit may be required if exposure severe.
鈥? Eyewash unit.
鈥? Ensure there is ready access to a safety shower.
GLOVE SELECTION INDEX
Glove selection is based on a modified presentation of the:
"Forsberg Clothing Performance Index".
The effect(s) of the following substance(s) are taken into account in the
computer-generated selection: isopropanol
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
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Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Protective Material CPI *.
________________________________
NITRILE+PVC A
PE/EVAL/PE A
NITRILE A
NEOPRENE A
PVC B
NAT+NEOPR+NITRILE C
NATURAL RUBBER C
NATURAL+NEOPRENE C
________________________________
* CPI - Chemwatch Performance Index
A: Best Selection
B: Satisfactory; may degrade after 4 hours continuous immersion
C: Poor to Dangerous Choice for other than short term immersion
NOTE: As a series of factors will influence the actual performance of the glove,
a final selection must be based on detailed observation. -
* Where the glove is to be used on a short term, casual or infrequent basis,
factors such as "feel" or convenience (e.g. disposability), may dictate a choice
of gloves which might otherwise be unsuitable following long-term or frequent
use. A qualified practitioner should be consulted.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of
breathing zone contaminant and the chemical nature of the contaminant.
Protection Factors (defined as the ratio of contaminant outside and inside the
mask) may also be important.
Breathing Zone Maximum Half-face Full-Face
Level ppm Protection Factor Respirator Respirator
(volume)
1000 10 A-AUS -
1000 50 - A-AUS
5000 50 Airline * -
5000 100 - A-2
10000 100 - A-3
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and
conditions of use determine the type of personal
protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
For flammable liquids and flammable gases, local exhaust ventilation or a
process enclosure ventilation system may be required. Ventilation equipment
should be explosion-resistant.
Air contaminants generated in the workplace possess varying "escape" velocities
which, in turn, determine the "capture velocities" of fresh circulating air
required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
solvent " "vapours " degreasing "etc. 0.25-0.5 m/s (50-100 f/min.)
" evaporating from tank (in still
air).
aerosols " fumes from pouring 0.5-1 m/s (100-200 f/min.)
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Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
"operations " intermittent container
"filling " low speed conveyer
"transfers " "welding " spray "drift "
plating acid "fumes " pickling
(released at low velocity into zone of
active generation)
direct "spray " spray painting in 1-2.5 m/s (200-500 f/min.)
shallow "booths " drum "filling "
conveyer "loading " crusher "dusts "
gas discharge (active generation into
zone of rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or 1: Disturbing room air currents
favourable to capture
2: Contaminants of low toxicity or of 2: Contaminants of high toxicity
nuisance value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in 4: Small hood-local control only
motion
Simple theory shows that air velocity falls rapidly with distance away from the
opening of a simple extraction pipe. Velocity generally decreases with the
square of distance from the extraction point (in simple cases). Therefore the
air speed at the extraction point should be adjusted, accordingly, after
reference to distance from the contaminating source. The air velocity at the
extraction fan, for example, should be a minimum of 1-2 m/s (200-400 f/min.) for
extraction of solvents generated in a tank 2 meters distant from the extraction
point. Other mechanical considerations, producing performance deficits within
the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or
used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Clear, colourless highly flammable liquid with an odour of rubbing alcohol;
mixes with water, alcohol and ether.
PHYSICAL PROPERTIES
Liquid.
Mixes with water.
Molecular Weight: 60.11 Boiling Range (掳C): 82.0
Melting Range (掳C): -88.5 Specific Gravity (water=1): 0.78 @ 25 C
Solubility in water (g/L): Miscible pH (as supplied): Not applicable
pH (1% solution): Not applicable Vapour Pressure (kPa): 4.4 @ 20 C
Volatile Component (%vol): 100 Evaporation Rate: 2.4 BuAc=1
Relative Vapour Density (air=1): 2.07 Flash Point (掳C): 11.7
Lower Explosive Limit (%): 2.3 Upper Explosive Limit (%): 12.7
Autoignition Temp (掳C): 456 Decomposition Temp (掳C): Not Available
State: Liquid Viscosity: Not Available
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Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
鈥? Presence of incompatible materials.
鈥? Product is considered stable.
鈥? Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be damaging to the health of the
individual.
Overexposure to non-ring alcohols causes nervous system symptoms. These include
headache, muscle weakness and inco-ordination, giddiness, confusion, delirium
and coma. Digestive symptoms may include nausea, vomiting and diarrhoea.
Aspiration is much more dangerous than ingestion because lung damage can occur
and the substance is absorbed into the body. Alcohols with ring structures and
secondary and tertiary alcohols cause more severe symptoms, as do heavier
alcohols.
EYE
Although the liquid is not thought to be an irritant (as classified by EC
Directives), direct contact with the eye may produce transient discomfort
characterised by tearing or conjunctival redness (as with windburn).
SKIN
There is some evidence to suggest that the material may cause mild but
significant inflammation of the skin either following direct contact or after a
delay of some time. Repeated exposure can cause contact dermatitis which is
characterised by redness, swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under
EC Directives); the material may still produce health damage following entry
through wounds, lesions or abrasions.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions,
may produce systemic injury with harmful effects. Examine the skin prior to the
use of the material and ensure that any external damage is suitably protected.
The material may cause skin irritation after prolonged or repeated exposure and
may produce on contact skin redness, swelling, the production of vesicles,
scaling and thickening of the skin.
Most liquid alcohols appear to act as primary skin irritants in humans.
Significant percutaneous absorption occurs in rabbits but not apparently in man.
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material
during the course of normal handling, may be damaging to the health of the
individual.
There is some evidence to suggest that the material can cause respiratory
irritation in some persons. The body's response to such irritation can cause
further lung damage.
Aliphatic alcohols with more than 3-carbons cause headache, dizziness,
drowsiness, muscle weakness and delirium, central depression, coma, seizures and
behavioural changes. Secondary respiratory depression and failure, as well as
low blood pressure and irregular heart rhythms, may follow. Nausea and vomiting
are seen, and liver and kidney damage is possible as well following massive
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Section 11 - TOXICOLOGICAL INFORMATION
exposures. Symptoms are more acute the more carbons there are in the alcohol.
If exposure to highly concentrated solvent atmosphere is prolonged this may lead
to narcosis, unconsciousness, even coma and possible death.
Acute effects from inhalation of high vapour concentrations may be chest and
nasal irritation with coughing, sneezing, headache and even nausea.
CHRONIC HEALTH EFFECTS
There has been some concern that this material can cause cancer or mutations but
there is not enough data to make an assessment.
TOXICITY AND IRRITATION
TOXICITY IRRITATION
Oral (human) LDLo: 3570 mg/kg Skin (rabbit): 500 mg - Mild
Oral (human) TDLo: 223 mg/kg Eye (rabbit): 10 mg - Moderate
Oral (man) TDLo: 14432 mg/kg Eye (rabbit): 100mg/24hr-Moderate
Oral (rat) LD50: 5045 mg/kg Eye (rabbit): 100 mg - SEVERE
Dermal (rabbit) LD50: 12800 mg/kg
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC)
Carcinogens: isopropanol Category: Group 3: Not classifiable as to
carcinogenicity to humans
Section 12 - ECOLOGICAL INFORMATION
"log Kow (Sangster 1997):" 0.05
"log Pow (Verschueren 1983):" -0.5714285
BOD5: 60%
BOD20: 78%
COD: 2.23
ThOD: 2.4
"Half-life Soil - High (hours):" 168
"Half-life Soil - Low (hours):" 24
"Half-life Air - High (hours):" 72
"Half-life Air - Low (hours):" 6.2
"Half-life Surface water - High (hours):" 168
"Half-life Surface water - Low (hours):" 24
"Half-life Ground water - High (hours):" 336
"Half-life Ground water - Low (hours):" 48
"Aqueous biodegradation - Aerobic - High (hours):" 168
"Aqueous biodegradation - Aerobic - Low (hours):" 24
"Aqueous biodegradation - Anaerobic - High (hours):" 672
"Aqueous biodegradation - Anaerobic - Low (hours):" 96
"Photooxidation half-life water - High (hours):" 1.90E+05
"Photooxidation half-life water - Low (hours):" 4728
"Photooxidation half-life air - High (hours):" 72
"Photooxidation half-life air - Low (hours):" 6.2
DO NOT discharge into sewer or waterways.
log Kow: -0.16- 0.28
Half-life (hr) air: 33-84
Half-life (hr) H2O surface water: 130
Henry's atm m鲁 /mol: 8.07E-06
BOD 5 if unstated: 1.19,60%
COD: 1.61-2.30,97%
ThOD: 2.4
Aquatic toxicity
(fish) 24-96h TLm: 42.5-240 mg/l
(fish) 96h LC50: 4200-9640 mg/l *
(daphnia) 48h EC50: 2285 mg/l *
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 14 of 15
Section 12 - ECOLOGICAL INFORMATION
BOD 20: >70% * * [Akzo Nobel]
Section 13 - DISPOSAL CONSIDERATIONS
鈥? Recycle wherever possible.
鈥? Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility
can be identified.
鈥? Dispose of by: Burial in a licenced land-fill or Incineration in a licenced
apparatus (after admixture with suitable combustible material)
鈥? Decontaminate empty containers. Observe all label safeguards until containers
are cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
Labels Required
flammable liquid
HAZCHEM
2[Y]E
Land Transport UNDG:
Dangerous Goods Class: 3 Subrisk: None
UN Number: 1219 Packing Group: II
Shipping Name:ISOPROPANOL (ISOPROPYL ALCOHOL)
Edit
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1219 Packing Group: II
ERG Code: 3L
Shipping Name: Isopropanol
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1219 Packing Group: II
EMS Number: None
Shipping Name: ISOPROPANOL (ISOPROPYL ALCOHOL)
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
None
REGULATIONS
isopropanol (CAS: 67-63-0) is found on the following regulatory lists;
Australia High Volume Industrial Chemical List (HVICL)
ISOPROPANOL
Chemwatch Material Safety Data Sheet
Issue Date: 6-Mar-2006 CHEMWATCH 1219
A317TC CD 2006/2 Page 15 of 15
Section 15 - REGULATORY INFORMATION
Australia Inventory of Chemical Substances (AICS)
International Agency for Research on Cancer (IARC) Carcinogens
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
This document is copyright. Apart from any fair dealing for the purposes of
private study, research, review or criticism, as permitted under the Copyright
Act, no part may be reproduced by any process without written permission from
CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 6-Mar-2006
Print Date: 28-Jun-2006
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