VIRBAC (AUSTRALIA) PTY. LTD.
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MATERIAL SAFETY DATA SHEET
Lethabarb Date of Issue
Product Name:
Revision A 24 November,
Lethabarb Euthanasia Injection 2004
Section 1 - Identification of Chemical Product and Company
Company: Virbac (Australia) Pty. Ltd ABN 77 003 268 871
15 Pritchard Place, Peakhurst, NSW 2210, Australia
Address
Locked Bag 1000, Peakhurst Delivery Centre, Peakhurst, NSW 2210, Australia
(02) 9533 2000 or 1800 242 100
Telephone:
(02) 9533 1522
Fax:
As above during business hours; answering machine after hours
Emergency phone
Substance: Active ingredient is a barbiturate derivative.
Trade Name: Lethabarb Euthanasia Injection
Product Use: Injectable rapid euthanasia agent for dogs and cats.
Creation Date: June, 2002
Revision Date: November, 2004
Section 2 - Hazards Identification
STATEMENT OF HAZARDOUS NATURE
This product is classified as: Hazardous according to the criteria of NOHSC Australia.
Dangerous according to the Australian Dangerous Goods (ADG) Code.
Risk Phrases: R25, R36/37/38. Toxic if swallowed. Irritating to eyes, respiratory system and skin.
Safety Phrases: S20, S23, S38, S24/25. When using, do not eat or drink. Do not breathe mists. In case of
insufficient ventilation, wear suitable respiratory equipment. Avoid contact with skin and eyes.
SUSDP Classification: S4
ADG Classification: Class 6.1 (TOXIC LIQUID, INORGANIC, N.O.S.)
UN Number: 3287
Emergency Overview
Physical Description & colour: Clear green solution in amber glass bottle.
Odour: No data.
Major Health Hazards: In all cases of excessive dose intake, the symptoms would be as follows: Nystagmus (rapid
eye movements), miosis (contraction of pupils), slurred speech and ataxia (uncoordination in movements). With
overdose, coma, respiratory and cardiovascular depression with hypotension (lowering of blood pressure) and shock
leading to death. Also after rapid intravenous administration, apnoea (stop in respiration) may occur.
Potential Health Effects
Extremely dangerous, especially if injected intravenously as it will cause death very rapidly.
We suggest that this product only be used when the user is in the presence of another responsible adult.
Due to the high concentration of the active ingredient in this product, the principal danger is due to acute toxicity.
Chronic toxicity would appear if extremely low doses of the product were administered over a prolonged period
(dependence). This is very unlikely to occur with this product.
Inhalation
Short term exposure: This product is an inhalation irritant. Symptoms may include headache, irritation of nose and
throat and increased secretion of mucous in the nose and throat. Other symptoms may also become evident, but they
should disappear after exposure has ceased. The product may be absorbed if it is actually instilled into the
nose.
Skin Contact:
Short term exposure: This product is a skin irritant. Symptoms may include itchiness and reddening of contacted
skin. Other symptoms may also become evident, but all should disappear once exposure has ceased. Not normally
absorbed through the skin, unless applied on extensive skin lesions (broken skin).
Eye Contact:
Short term exposure: Irritating to eyes. Some absorption may occur through the eye mucosa. In addition, this
product is an eye irritant. Symptoms may include stinging and reddening of eyes and watering which may become
VIRBAC (AUSTRALIA) PTY. LTD.
Document No: Page: 2 of 5
MATERIAL SAFETY DATA SHEET
Lethabarb Date of Issue
Product Name:
Revision A 24 November,
Lethabarb Euthanasia Injection 2004
copious. Other symptoms may also become evident. If exposure is brief, symptoms should disappear once exposure
has ceased. However, lengthy exposure or delayed treatment may cause permanent damage.
Ingestion:
Short term exposure: Toxic if swallowed. Can cause death, as pentobarbitone sodium is well absorbed by the oral
route. First symptoms of intoxication (narcosis) may occur as early as 15 minutes after intake (with as low a dose as
100 to 200 mg for an adult person, i.e. less than 1 mL of LETHABARB). The acute oral LD50 of the active ingredient in
the rat is 118 mg/kg.
Carcinogen Status:
NOHSC: No significant ingredient is classified as carcinogenic by NOHSC.
NTP: No significant ingredient is classified as carcinogenic by NTP.
IARC: No significant ingredient is classified as carcinogenic by IARC.
Section 3 鈥? Composition/Information on Ingredients
Ingredients CAS No Conc,% TWA (mg/m3) STEL (mg/m3)
Pentobarbital sodium 57-33-0 29.7 not set not set
Other non hazardous ingredients secret <10 not set not set
Water 7732-18-5 to 100 not set not set
This is a commercial product whose exact ratio of components may vary slightly. Minor quantities of other non
hazardous ingredients are also possible.
The TWA exposure value is the average airborne concentration of a particular substance when calculated over a normal 8 hour working day for a 5
day working week. The STEL (Short Term Exposure Limit) is an exposure value that should not be exceeded for more than 15 minutes and should
not be repeated for more than 4 times per day. There should be at least 60 minutes between successive exposures at the STEL. The term "peak "is
used when the TWA limit, because of the rapid action of the substance, should never be exceeded, even briefly.
Section 4 - First Aid Measures
General Information:
You should call The Poisons Information Centre if you feel that you may have been poisoned, burned or irritated by
this product. The number is 13 1126 from anywhere in Australia and is available at all times. Have this MSDS with
you when you call.
This product contains a barbiturate (sodium pentobarbitone) in a very high concentration form. It is intended to kill
animals and should not be used for any other purposes, such as anaesthesia, for example. Gastric lavage, oral
administration of activated charcoal, intensive symptomatic and supportive therapy are part of the treatment. The
solution being extremely alkaline, necrosis or gangrene can follow subcutaneous injection.
Inhalation: If inhalation occurs, contact a Poisons Information Centre, or call a doctor at once. Remove source of
contamination or move victim to fresh air. If breathing is difficult, oxygen may be beneficial if administered by trained
personnel, preferably on a doctor's advice. DO NOT allow victim to move about unnecessarily. Symptoms of
pulmonary oedema can be delayed up to 48 hours after exposure.
Skin Contact: Quickly and gently, blot or brush away excess chemical. Wash gently and thoroughly with water (use
non-abrasive soap if necessary) for 20 minutes or until chemical is removed. Under running water, remove
contaminated clothing, shoes and leather goods (e.g. watchbands and belts). If irritation persists, repeat flushing and
obtain medical advice. Completely decontaminate clothing, shoes and leather goods before reuse or discard.
Eye Contact: If poisoning occurs, contact a Poisons Information Centre. Urgent hospital treatment is likely to be
needed. Quickly and gently blot or brush away chemical. Immediately flush the contaminated eye(s) with lukewarm,
gently flowing water for 20 minutes or until the chemical is removed, while holding the eyelid(s) open. Take care not to
rinse contaminated water into the unaffected eye or onto the face.
Ingestion: If swallowed, rinse mouth thoroughly with water and contact a Poisons Information Centre, or call a
doctor at once. Give activated charcoal if instructed.
Section 5 鈥? Fire Fighting Measures
Fire and Explosion Hazards: There is no risk of an explosion from this product under normal circumstances if it is
involved in a fire.
Fire decomposition products from this product may be toxic if inhaled. Take appropriate protective measures.
This product is likely to decompose only after heating to dryness, followed by further strong heating.
Extinguishing Media: Not Combustible. Use extinguishing media suited to burning materials. water fog. Water fog
or fine spray is the preferred medium for large fires.
VIRBAC (AUSTRALIA) PTY. LTD.
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MATERIAL SAFETY DATA SHEET
Lethabarb Date of Issue
Product Name:
Revision A 24 November,
Lethabarb Euthanasia Injection 2004
Fire Fighting: When fighting fires involving significant quantities of this product, no special equipment is believed to
be necessary.
Flash point: Does not burn.
Upper Flammability Limit: Does not burn.
Lower Flammability Limit: Does not burn.
Autoignition temperature: Not applicable - does not burn.
Flammability Class: Does not burn.
Section 6 鈥? Accidental Release Measures
Accidental release: In the event of a major spill, prevent spillage from entering drains or water courses. Evacuate
the spill area and deny entry to unnecessary and unprotected personnel. Immediately call the Fire Brigade. Wear full
protective chemically resistant clothing including face mask, face shield, gauntlets and self contained breathing
apparatus. See above under Personal Protection regarding Australian Standards relating to personal protective
equipment. Suitable materials for protective clothing include rubber, PVC. Stop leak if safe to do so, and contain spill.
Absorb onto sand, vermiculite or other suitable absorbent material. If spill is too large or if absorbent material is not
available, try to create a dike to stop material spreading or going into drains or waterways. Avoid using sawdust or
other combustible material. Because of the toxicity of this product, special personal care should be taken in any
cleanup operation. Sweep up and shovel or collect recoverable product into labelled containers for recycling or
salvage, and dispose of promptly. After spills, wash area preventing runoff from entering drains. If a significant
quantity of material enters drains, advise emergency services. Full details regarding disposal of used containers,
spillage and unused material may be found on the label. If there is any conflict between this MSDS and the label,
instructions on the label prevail. Ensure legality of disposal by consulting regulations prior to disposal. Thoroughly
launder protective clothing before storage or re-use. Advise laundry of nature of contamination when sending
contaminated clothing to laundry.
Section 7 鈥? Handling and Storage
Handling: Keep exposure to this product to a minimum, and minimise the quantities kept in work areas. Check
Section 8 of this MSDS for details of personal protective measures, and make sure that those measures are followed.
The measures detailed below under "Storage" should be followed during handling in order to minimise risks to
persons using the product in the workplace. Also, avoid contact or contamination of product with incompatible
materials listed in Section 10.
Storage: This product is a Scheduled Poison. Observe all relevant regulations regarding sale, transport and storage
of this class of poison. Store in a cool, well ventilated area. Check containers periodically for leaks. Containers should
be kept closed in order to minimise contamination. Make sure that the product does not come into contact with
substances listed under "Materials to avoid" in Section 10. If you keep more than 1000kg or 1000L of Toxic
Substances of Packaging Group III, you will require a license to do so. If you have any doubts, we suggest you
contact your licensing authority in order to clarify your obligations. Check packaging - there may be further storage
instructions on the label.
Section 8 Exposure Controls and Personal Protection
The following Australian Standards will provide general advice regarding safety clothing and equipment:
Respiratory equipment: AS/NZS 1715, Protective Gloves: AS 2161, Industrial Clothing: AS2919, Industrial Eye
Protection: AS1336 and AS/NZS 1337, Occupational Protective Footwear: AS/NZS2210.
TWA (mg/m3) STEL (mg/m3)
Exposure Limits
Exposure limits have not been established by NOHSC for any of the significant ingredients in this product.
Ventilation: No special ventilation requirements are normally necessary for this product. However make sure that
the work environment remains clean and that dusts are minimised.
Eye Protection: Protective glasses or goggles must be worn when this product is being used. Failure to protect
your eyes may lead to severe harm to eyes or to general health. Emergency eye wash facilities must also be available
in an area close to where the product is being used.
Skin Protection: Prevent skin contact by wearing impervious gloves, clothes and, preferably, apron. Make sure that
all skin areas are covered. See below for suitable material types.
Protective Material Types: We suggest that protective clothing be made from the following materials: rubber,
PVC.
Respirator: If there is a significant chance that vapours or mists are likely to build up in the area where this product
is being used, we recommend that you use a respirator. It should be fitted with a suitable cartridge.
VIRBAC (AUSTRALIA) PTY. LTD.
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MATERIAL SAFETY DATA SHEET
Lethabarb Date of Issue
Product Name:
Revision A 24 November,
Lethabarb Euthanasia Injection 2004
Eyebaths or eyewash stations and safety deluge showers should be provided near to where this product is being
used.
Section 9 - Physical and Chemical Properties:
Physical Description & colour: Clear green solution in amber glass bottle.
Odour: No data.
Boiling Point: Approximately 100掳C at 100kPa.
Freezing/Melting Point: Approximately 0掳C.
Volatiles: Water component.
Vapour Pressure: 2.37 kPa at 20掳C (water vapour pressure).
Vapour Density:
Specific Gravity: 1.08
Water Solubility: Completely soluble in water.
pH: 11.0 approx
Volatility: No data.
Odour Threshold: No data.
Evaporation Rate: No data.
Coeff Oil/water distribution: No data
Autoignition temp: Not applicable - does not burn.
Section 10 鈥? Stability and Reactivity
Reactivity: This product is unlikely to react or decompose under normal storage conditions. However, if you have
any doubts, contact the supplier for advice on shelf life properties.
Conditions to Avoid: None known.
Incompatibilities: strong acids, strong bases.
Fire Decomposition: Carbon dioxide, and if combustion is incomplete, carbon monoxide and smoke. Nitrogen and
its compounds, and under some circumstances, oxides of nitrogen. Occasionally hydrogen cyanide gas. Water.
sodium compounds. Carbon monoxide poisoning produces headache, weakness, nausea, dizziness, confusion,
dimness of vision, disturbance of judgment, and unconsciousness followed by coma and death. Hydrogen cyanide
poisoning signs and symptoms are weakness, dizziness, headache, nausea, vomiting, coma, convulsions, and death.
Death results from respiratory arrest. Hydrogen cyanide gas acts very rapidly; symptoms and death can both occur
quickly.
Polymerisation: This product is unlikely to undergo polymerisation processes.
Section 11 鈥? Toxicological Information
Target Organs: There is no data to hand indicating any particular target organs.
Classification of Hazardous Ingredients
Ingredient Risk Phrases
Pentobarbital Sodium: R25, R36/37/38
Pentobarbital Sodium: LD50 Oral, Rat 118mg/kg
Section 12 鈥? Ecological Information
Insufficient data to be sure of status.
Section 13 鈥? Disposal Considerations
Disposal: Instructions concerning the disposal of this product and its containers are given on the product label.
These should be carefully followed.
Section 14 鈥? Transport Information
ADG Code: 3287, TOXIC LIQUID, INORGANIC, N.O.S.
Hazchem Code: 2X
Special Provisions: SP109, SP185, SP274
Packaging Group: III
VIRBAC (AUSTRALIA) PTY. LTD.
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MATERIAL SAFETY DATA SHEET
Lethabarb Date of Issue
Product Name:
Revision A 24 November,
Lethabarb Euthanasia Injection 2004
Packaging Method: 3.8.6
This product is classed as UN3287, Dangerous Goods Class 6.1 Toxic Substances. Proper Shipping name is TOXIC
LIQUID, INORGANIC, N.O.S.. Class 6 Toxic Substances shall not be loaded in the same vehicle or packed in the
same freight container with Classes 1 (Explosives), 3 (Flammable Liquids where the Flammable Liquid is
nitromethane), 5.1 (Oxidising Agents where the Toxic Substances are Fire Risk Substances), 5.2 (Organic Peroxides
where the Toxic Substances are Fire Risk Substances), 8 (Corrosive Substances where the Toxic Substances are
cyanides and the Corrosives are acids), Foodstuffs and foodstuff empties. They may however be loaded in the same
vehicle or packed in the same freight container with Classes, 2.1 (Flammable Gases), 2.2 (Non-Flammable, Non-
Toxic Gases), 2.3 (Toxic Gases), 3 (Flammable liquids, except where the flammable liquid is nitromethane), 4.1
(Flammable Solids), 4.2 (Spontaneously Combustible Substances), 4.3 (Dangerous When Wet Substances), 5.1
(Oxidising Agents except where the Toxic Substances are Fire Risk Substances), 5.2 (Organic Peroxides except
where the Toxic Substances are Fire Risk Substances), 7 (Radioactive Substances), 8 (Corrosive Substances except
where the Toxic Substances are cyanides and the Corrosives are acids), 9 (Miscellaneous Dangerous Goods)
Section 15 鈥? Regulatory Information
AICS: All of the significant ingredients in this formulation are to be found in the public AICS Database.
The following ingredient: Pentobarbital sodium is listed in the SUSDP.
Section 16 鈥? Other Information
This MSDS contains only safety-related information. For other data see product literature.
Contact point: Technical Manager, QA Manager or R&D Director
Telephone (02) 9533 2000 or 1800 242 100
Fax (02) 9533 1522
Acronyms:
ADG Code Australian Code for the Transport of Dangerous Goods by Road and Rail
AICS Australian Inventory of Chemical Substances
CAS number Chemical Abstracts Service Registry Number
Hazchem Number Emergency action code of numbers and letters that provide information to
emergency services especially firefighters
IARC International Agency for Research on Cancer
NOHSC National Occupational Health and Safety Commission
NOS Not otherwise specified
NTP National Toxicology Program (USA)
R-Phrase Risk Phrase
SUSDP Standard for the Uniform Scheduling of Drugs & Poisons
UN Number United Nations Number
THIS MSDS SUMMARISES OUR BEST KNOWLEDGE OF THE HEALTH AND SAFETY HAZARD INFORMATION OF THE PRODUCT AND
HOW TO SAFELY HANDLE AND USE THE PRODUCT IN THE WORKPLACE. EACH USER MUST REVIEW THIS MSDS IN THE CONTEXT OF
HOW THE PRODUCT WILL BE HANDLED AND USED IN THE WORKPLACE.
IF CLARIFICATION OR FURTHER INFORMATION IS NEEDED TO ENSURE THAT AN APPROPRIATE RISK ASSESSMENT CAN BE MADE,
THE USER SHOULD CONTACT THIS COMPANY SO WE CAN ATTEMPT TO OBTAIN ADDITIONAL INFORMATION FROM OUR SUPPLIERS
OUR RESPONSIBILITY FOR PRODUCTS SOLD IS SUBJECT TO OUR STANDARD TERMS AND CONDITIONS, A COPY OF WHICH IS SENT
TO OUR CUSTOMERS AND IS ALSO AVAILABLE ON REQUEST.
Please read all labels carefully before using product.
This MSDS is prepared in accord with the NOHSC document 鈥淣ational Code of Practice for the
Preparation of Material Safety Data Sheets鈥? 2nd Edition [NOHSC:2011(2003)]
Copyright 漏 Kilford & Kilford Pty Ltd, November, 2004.
http://www.kilford.com.au/ Phone (02)9251 4532
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