Page 1 of 3
MSDS: LSS01:4
Issued: 18th May 2000
Linco-Spectin庐 Antibiotic Injectable Solution (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
-NON HAZARDOUS ACCORDING TO THE CRITERIA OF WORKSAFE AUSTRALIA-
IDENTIFICATION
PRODUCT NAME:
LINCO-SPECTIN庐 Antibiotic Injectable Solution
Other Names: Linco-Spectin Sterile Solution
Manufacturers Product Code: 03061803025
UN: Not Applicable CLASS: Not Applicable SUB RISK: Not Applicable HAZCHEM CODE: Not Applicable
EPG: Not Applicable PACKAGING GROUP: Not Applicable POISON SCHEDULE: 4
USE: Antibiotic.
PHYSICAL DESCRIPTION/PROPERTIES:
Appearance: Colourless to slightly yellow solution. May have a slight haze which does not affect the
potency.
Boiling Point: Not applicable.
Melting Point: Not applicable.
Vapour Pressure: Not applicable.
Specific Gravity: Not applicable.
Flash Point: Not applicable (aqueous solution)
Percent Volatiles: Nil.
Solubility in Water (g/L):Soluble.
pH: 3.0 to 3.5
OTHER PROPERTIES:
Nil.
INGREDIENTS CAS No PROPORTION
Lincomycin as Lincomycin hydrochloride 7179-49-9 50 mg/ml
Spectinomycin 1695-77-8 100 mg/ml
Benzyl alcohol 100-51-6 < 1%
Water for Injection Balance
Page 2 of 3
MSDS: LSS01:4
Issued: 18th May 2000
Linco-Spectin庐 Antibiotic Injectable Solution (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
HEALTH HAZARD INFORMATION
ACUTE HEALTH EFFECTS
Swallowed: May cause an acute hypersensitivity reaction.
Eye: Minimally irritating to the eyes (Rabbit).
Skin: May cause mild to severe allergic reactions in some individuals.
Inhalation: May cause mild to severe allergic reactions in some individuals.
CHRONIC HEALTH EFFECTS:
Overexposure may cause skin, eye and upper respiratory tract irritation or allergic reactions. Repeated over
exposure to lincomycin hydrochloride may cause abdominal cramps, diarrhoea and colitis. This may begin several
weeks after exposure has ceased.
TOXICITY DATA:
Lincomycin hydrochloride: LD50 (Rat, intravenous) 342mg/kg
LD50 (Rat, oral) > 4000mg/kg
LD50 (Rat, subcutaneous) 9778mg/kg
LD50 (Mouse, intravenous) 214mg/kg
LD50 (Mouse, IP) 1000mg/kg
Spectinomycin sulfate tetrahydrate: LD50 (Rat, oral) > 5000mg/kg
LD50 (Mouse, intravenous) 1022mg/kg
LD50 (Mouse, IP) 3577mg/kg
Carcinogenicity: Negative
Genotoxicity: Negative
Teratogenicity: No teratogenic effects seen in rats or dogs
FIRST AID PROCEDURES:
Swallowed: Contact a physician or Poisons Information Centre.
Eye: Flush with water for 15 minutes.
Skin: Wash with soap and water. Remove contaminated clothing.
Inhalation: Remove from exposure.
First Aid Facilities: No specific recommendation.
ADVICE TO DOCTOR:
Treat hypersensitivity reactions as indicated clinically.
PRECAUTIONS FOR USE
EXPOSURE STANDARDS:
None assigned by Worksafe Australia. Pharmacia & Upjohn suggest limit: 0.2mg/cubic metre.
ENGINEERING CONTROLS:
Ventilation: Local exhaust
PERSONAL PROTECTION:
Not required.
Page 3 of 3
MSDS: LSS01:4
Issued: 18th May 2000
Linco-Spectin庐 Antibiotic Injectable Solution (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
SAFE HANDLING INFORMATION
STORAGE & TRANSPORT
Store at 30掳C. No special additional transport precautions are necessary.
SPILLS & DISPOSAL
Provide ventilation and respiratory, skin and eye protection for preventing overexposure. Keep out of drains.
Prevent entry to surface water, groundwater and soil. Vacuum-clean or scoop spilt material and place in a
container. Wash after handling and launder contaminated clothing before reuse.
WASTE DISPOSAL METHOD
Dispose of empty containers by wrapping with paper and putting in garbage. For larger quantities, incinerate in a
suitable licensed incinerator.
FIRE EXPLOSION
Wear self-contained breathing apparatus and full body protective equipment. Hazardous combustion products are
carbon monoxide, carbon dioxide, oxides of nitrogen and sulphur, hydrochloric acid. Extinguish using water,
carbon, dioxide or dry chemical powder.
OTHER INFORMATION
ECOTOXICITY:
No adverse effect 96 hour rainbow trout 980mg/litre; no adverse effect 96 hour bluegill 980mg/litre; no adverse
effect 48 hour daphnia maga > 900mg/litre. (Concentrations refer to lincomycin)
BIODEGRADABILITY:
Lincomycin hydrochloride melts with decomposition at 148掳C. It has no measurable vapour pressure; therefore it
is not expected to enter the air. Lincomycin hydrochloride is very soluble in water (500-1000mg/ml) and
undergoes hydrolysis at both acid and basic pH's at elevated temperatures. Lincomycin can be sorbed to soil, but
it is readily leached away from soils. Lincomycin is expected to be relatively mobile and migrate toward the
aquatic compartment.
Lincomycin has a low octanol-water partition coefficient at all pH's. The octanol-water partition at pH 7 is 2.550.
Calculated flowing and static bioaccumulation factors are 2.21 and 9.96, respectively. Lincomycin will be
expected to migrate to the aqueous environment, but it should not bioaccumulate in aquatic organisms.
Lincomycin will have some initial inhibitory effects on the most sensitive micro-organisms until it is degraded.
Small amounts sent to sanitary sewage will not adversely affect the abiotic flora of sewage treatment facilities.
PERSISTENCE IN SOIL AND WATER:
Lincomycin hydrochloride can undergo hydrolysis at both acid and basic pH's at elevated temperatures. However,
in the pH range 3-6 at room temperature degradation is small. Lincomycin bioactivity is readily degraded by
mixtures or urine, faeces and soil. The half-life of degradation was about 20 days.
CONTACT POINT
Technical Services Veterinarian
Business Hours: (02) 9890 7177
After Hours: 0412 004 113
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