Page 1 of 3
MSDS: LMXSP:6
Issued: 18th May 2000
LINCOMIX庐 SOLUBLE POWDER (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
-NON HAZARDOUS ACCORDING TO THE CRITERIA OF WORKSAFE AUSTRALIA-
IDENTIFICATION
PRODUCT NAME:
LINCOMIX庐 ANTIBIOTIC SOLUBLE POWDER
LINCOMIX庐 800 ANTIBIOTIC SOLUBLE POWDER
Other Names: None
Manufacturers Product Code: 06 096209 010
UN: None Allocated CLASS: None Allocated SUB RISK: Not Applicable HAZCHEM CODE: Not Applicable
EPG: Not Applicable PACKAGING GROUP: Not Applicable POISON SCHEDULE: 4
USE: Antibiotic.
PHYSICAL DESCRIPTION/PROPERTIES:
White to off-white free flowing powder, odourless or with a slight characteristic
Appearance:
pungent or bitter odour and taste.
Boiling Point: No Data Available.
145 - 147oC.
Melting Point:
< 5 x 10-4 torr at 21-22oC
Vapour Pressure:
Specific Gravity: No Data Available.
Flash Point: Not relevant.
Percent Volatiles: Nil.
Solubility - Water (g/L): 500.
pH: 3.0 - 5.5 at 100g/L solution.
OTHER PROPERTIES:
Solubility in Organic Solvents (g/L): Ethanol (96%): 40
Dimethyl formamide: 20
Acetone: Very slightly
Chloroform: Practically insoluble
Ether: Practically insoluble
INGREDIENTS CAS No PROPORTION
Lincomycin 7179-49-9 40% to 80%
Silicon dioxide 7631-86-9 < 1%
Lactose to 100%
Page 2 of 3
MSDS: LMXSP:6
Issued: 18th May 2000
LINCOMIX庐 SOLUBLE POWDER (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
HEALTH HAZARD INFORMATION
ACUTE HEALTH EFFECTS
Swallowed: May cause nausea and vomiting.
Eye: May cause eye irritation
Skin: May cause skin irritation and mild to severe allergic reactions in some individuals.
Inhalation: May cause irritation to the respiratory passages and mild to severe allergic reactions in some
individuals.
CHRONIC HEALTH EFFECTS:
Overexposure may cause skin, eye and upper respiratory tract irritation or allergic reactions. Repeated
overexposure to lincomycin hydrochloride may cause abdominal cramps, diarrhoea and colitis. This may begin
several weeks after exposure has ceased.
Hypersensitivity reactions such as angioeurotic oedema, serum sickness, and anaphylaxis have been reported from
exposure to lincomycin hydrochloride. Some of these people were known to be sensitive to penicillin. Rare
instances of erythema multiforme, some resembling Stevens-Johnsone Syndrome, have been associated with
lincomycin hydrochloride.
TOXICITY DATA:
Lincomycin hydrochloride: Rat LD50 oral 4000mg/kg
subcutaneous 9778mg/kg
intravenous 342mg/kg
Lincomycin hydrochloride: Mouse LD50 intraperitoneal 1000mg/kg
intravenous 214mg/kg
Carcinogenicity: Negative
Genotoxicity: Negative
Teratogenicity: No teratogenic effects seen in rats or dogs
Sensitivity: May cause hypersensitivity reactions
FIRST AID PROCEDURES:
Swallowed: Rinse mouth out with water ensuring that mouth wash is not swallowed. Seek medical attention.
Eye: Hold eyelids open and rinse the eye continuously with a gentle stream of clean running water for at
least fifteen minutes. Seek medical attention.
Skin: Remove contaminated clothing and wash the skin thoroughly with soap and water. Use water alone,
if soap is unavailable.
Inhalation: Remove from exposure.
ADVICE TO DOCTOR:
Treat hypersensitivity reactions as indicated clinically. Lincomycin has been shown to have neuromuscular-
blocking properties that may enhance the action of other neuromuscular-blocking agents. if an allergic reaction
should occur, the usual agents (epinephrine, corticosteroids, antihistamines) should be used as indicated.
Page 3 of 3
MSDS: LMXSP:6
Issued: 18th May 2000
LINCOMIX庐 SOLUBLE POWDER (VETERINARY)
Pharmacia & Upjohn Pty Limited
ACN 000 185 526
MATERIAL SAFETY 59 Kirby Street
Rydalmere NSW 2116
DATA SHEET Australia
Ph:+61 2 9890 7177
Fax:+61 2 9890 5391
PRECAUTIONS FOR USE
EXPOSURE STANDARDS:
There are no known exposure standards for the product or its ingredients.
Silicon dioxide (7631-86-9): E.S. TWA: - ppm, 2mg/m3 ; STEL: - ppm, - mg/m3, as respirable dust.
ENGINEERING CONTROLS:
Mechanical ventilation indoors.
PERSONAL PROTECTION:
For the industrial situation (not end-use); wear approved respirator, rubber gloves, safety glasses with side shields,
approved footwear and coverings for exposed skin areas.
FLAMMABILITY:
Non combustible
SAFE HANDLING INFORMATION
STORAGE
Store below 30掳C. Protect from light. Protect packaging against physical damage. Keep out of reach of children.
No special additional transport precautions are necessary.
SPILLS & DISPOSAL
SPILLS: Provide ventilation and respiratory, skin and eye protection for preventing overexposure. Keep out
of drains. Prevent entry to surface water, groundwater and soil. Scoop or vacuum spilled material
(using a Hepa filtered system) and place in container. Wash after handling and launder
contaminated clothing before reuse.
DISPOSAL: Incinerate or dispose of in accordance with Federal, State and local regulations..
FIRE EXPLOSION
As with all organic powders (finely divided), it is advisable to eliminate explosion hazards by methods such as
grounding mechanical equipment in contact with the material to dissipate the potential build-up of static
electricity, inerting the atmosphere or controlling dust levels. There are no hazardous combustion or
decomposition products.
Wear self contained breathing apparatus. Extinguish using water, carbon dioxide or dry chemical.
OTHER INFORMATION
None.
CONTACT POINT
Technical Services Veterinarian
Business Hours: (02) 9890 7177
After Hours: 0412 004 113
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