Material Safety Data Sheet
Revision: 12/20/2005
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Actinomycin D 10415 200-063-6
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Actinomycin D 50-76-0 >98% --- R:28 Very toxic if swallowed.
R:40 Limited evidence of a
carcinogenic effect.
R:42/43 May cause
sensitization by inhalation and
skin contact.
S:22 Do not breathe dust.
S:28 After contact with skin,
wash immediately with plenty
of soap-suds.
S:36/37 Wear suitable
protective clothing and gloves.
S:45 In case of accident or if
you feel unwell, seek medical
advice immediately (show the
label where possible).
HAZARDS IDENTIFICATION CHIP
Very Toxic; Carcinogen, Category 3
HCS
Highly Toxic; Category 3 Carcinogen.
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and
wash before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give
oxygen. If not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate
medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Emits toxic fumes
under fire conditions. NFPA Rating: H=3 F=0 R=0.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Light
sensitive. Protect from light. Store +4掳C away from incompatible materials.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash. HMIS Rating: H=3 F=0 R=0.
MSDS information may be continued on back of page.
PHYSICAL AND CHEMICAL Appearance: Bright red powder Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Slightly soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical formula: C62-H86-N12-O16 Melting Point: 251掳C
STABILITY AND REACTIVITY Product is stable. Light sensitive. Protect from light. Hazardous decomposition products include oxides of
carbon and nitrogen. Incompatible with strong oxidizing agents, acids and bases. Hazardous polymerization will
not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: May be harmful if absorbed through the skin. Contact may cause irritation, dermatitis, and hypersensitive
individuals may experience an allergic reaction.
INHALATION: May be harmful if inhaled. May cause irritation to mucous membranes and upper respiratory
tract. Inhalation may result in spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis
and pulmonary edema.
INGESTION: May be fatal if swallowed. Chronic ingestion or excessive dosage may cause gastrointestinal
irritation, central nervous system disorders, bone marrow diseases, liver and kidney damage.
TARGET ORGAN(S): Bone Marrow, Liver and Kidneys.
ADDITIONAL INFORMATION:
May cause sensitization. Prolonged or repeated exposure may cause allergic reactions in certain sensitive
individuals. The NCI has found clear evidence for carcinogenicity. This product is or contains a component that
is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP or EPA classification. Possible risk of
congenital malformation in the fetus. Laboratory experiments have shown mutagenic effects. Overexposure
may cause reproductive disorders based on tests with laboratory animals.
Irritation, reproductive effects, mutation, tumorigenic and toxicity data listed in RTECS under AU1575000.
Only select RTECS information is provided here. Please see actual RTECS entry for complete information.
Oral Rat LD50 = 7.2 mg/kg (1960). Toxic effects include gastrointestinal with hypermotility and diarrhea and
changes in the blood.
Reproductive: Effects on embryo or fetus - fetotoxicity (except death, e.g. stunted fetus) (1980).
Tumorigenic data: Equivocal tumorigenic agent by RTECS criteria (1967).
Neoplastic by RTECS criteria (1975).
Carcinogenic by RTECS criteria (1970).
Carcinogenicity data:
IARC Cancer Review: Animal - Limited Evidence (1987).
Human - Inadequate Evidence (1987).
Group 3 - Agent is not classifiable as to its carcinogenicity to humans (1987).
NCI Carcinogenesis Studies: Clear evidence: rat.
No evidence: mouse.
Definition(s):
IARC = International Agency for Research on Cancer.
NCI = National Cancer Institute.
RTECS = Registry of Toxic Effects of Chemical Substances.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION Toxic solid, organic, n.o.s. (Actinomycin D), class 6.1, UN2811, PGII, Label: Toxic.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - No applicable information.
SARA 313 - No applicable information.
EPA TSCA Section 8(b) - This chemical substance is NOT specifically listed on the EPA TSCA Inventory. It is
supplied for research and developmental use only, by or directly under the supervision of technically qualified
individuals. NOT for manufacturing commercial purposes.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the State of California to cause
cancer and/or developmental toxicity.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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