Material Safety Data Sheet
Revision: 08/02/2004
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Vitamin A Palmitate 23330 201-228-5
AND COMPANY (with fillers)
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Vitamin A Palmitate 79-81-2 25-40% 鈥? For mixture/preparation:
R:63 Possible risk of harm to the
BHT (Stabilizer) 128-37-0 <5% ACGIH TLV-TWA: unborn child.
10 mg/m3 R:36/37/38 Irritating to eyes,
respiratory system and skin.
S:22 Do not breathe dust.
S:36/37/39 Wear suitable
protective clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Toxic for Reproduction, Category 3. Irritant.
HCS
Teratogen. Irritant.
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Dust explosion
hazard. Spontaneous ignition may occur when exposed to air and in contact with other materials such as cloth,
paper, wood and/or insulation. Emits toxic fumes under fire conditions.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. Collect in a manner that does not create dust and place in a suitable waste container. Avoid
contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Protect from light. Store
at +4掳C away from incompatible materials.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and NIOSH-
approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection. Use
respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of material
with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust, vapors or mists.
Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: Light yellow, fine granular powder beadlets Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Insoluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical formula: C36-H60-O2
MSDS information may be continued on back of page.
STABILITY AND REACTIVITY Product is stable. Avoid excessive heat and light. Protect from light. Dust explosion hazard. Spontaneous ignition
may occur when exposed to air and in contact with other materials such as cloth, paper, wood and/or insulation.
Hazardous decomposition products may include carbon oxides. Incompatible with strong oxidizing agents, copper,
copper alloys, iron, iron salts, peroxides, strong inorganic acids and strong bases. Hazardous polymerization will
not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation and/or allergic reaction. Skin reactions such as cracks in lips and around
mouth, dry skin, skin peeling, itching and redness may occur.
INHALATION: May cause irritation to mucous membranes and upper respiratory tract. Signs and symptoms
may include difficulty breathing, coughing, wheezing, inflamation and respiratory arrest.
INGESTION: Chronic ingestion or excessive dosage may cause nausea, vomiting, diarrhea, constipation,
cramps and loss of appetite. Acute and/or chronic toxicity may cause headache, irritability, tiredness,
stupor, nausea, vomiting, increase in intracranial pressure, generalized peeling of the skin after 24 hours, loss
of appetite, chapped lips, dry and itching skin, erythematous dermatitis, desquamation, disturbed hair growth,
loss of hair and bone decalcification.
TARGET ORGAN(S): Skin, Liver, Respiratory Tract, Gastrointestinal System, Central Nervous System and Skeletal
System.
ADDITIONAL INFORMATION:
Teratogenic and embryotoxic. Women of childbearing potential must avoid any and all exposure. May cause central
nervous system effects. Signs and symptoms may include headache, dizziness, drowsiness, fatigue and lack of
muscle coordination. May cause hepatic (liver) system effects. Signs and symptoms may include elevation of liver
enzyme levels and jaundice (yellowing of the eyes and skin). May cause allergic respiratory reactions. May cause
ulcers. May cause skeletal abnormalities.
Only select RTECS information is provided below. Please see actual RTECS entries for both Vitamin A Palmitate
and BHT for complete information.
Reproductive effects, toxicity and mutation data listed for Vitamin A Palmitate in RTECS under VH6860000.
Oral Rat LD50 = 7910 mg/kg (1982). Details of toxic effects not reported other than lethal dose value.
Reproductive: Effects on embryo or fetus included fetotoxicity (except death, e.g. stunted fetus)(1968),
extra-embryonic structures (e.g., placenta, umbilical cord) (1920) and fetal death
(1960-86).
Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number
of implants) (1966).
Specific developmental abnormalities - central nervous system, eye/ear, craniofacial
(1952), musculoskeletal system (1945), cardiovascular, gastrointestinal, urogenital
systems (1906/08) and endocrine system (1987).
Maternal effects - ovaries, fallopian tubes, uterus, cervix, vagina (1960).
Paternal effects - testes, epididymis, sperm duct (1950-60).
Reproductive effects, irritation, toxicity, tumorigenic and mutation data listed for BHT in RTECS under
GO7875000.
Irritation data: Human Skin 500 mg/48H = Mild. Rabbit Skin 500 mg/48H = Moderate.
Rabbit Eye 100 mg/48H = Moderate.
Toxicity data: Oral Rat LD50 = 890 mg/kg (1994). Details of toxic effects not reported other than lethal
dose value.
Reproductive: Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total
number of implants per corpora lutea) (1979-87).
Specific developmental abnormalities - musculoskeletal system (1949/50).
Tumorigenic data: carcinogenic by RTECS criteria (1982). neoplastic by RTCES criteria (1982).
Carcinogenicity data: IARC Cancer Review: Animal - Limited Evidence (1986).
Human - No Adequate Data (1986).
Group 3 - agent is not classifiable as to it鈥檚 carcinogenicity in humans (1987).
ACGIH TLV - Not classifiable as a human carcinogen (2002).
Definition(s): IARC = International Agency for Research on Cancer.
ACGIH = American Conference of Governmental Industrial Hygienists.
RTECS = Registry of Toxic Effects of Chemical Substances.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - No applicable information.
SARA 313 - No applicable information.
EPA TSCA Section 8(b) - All ingredients are listed on the Chemical Inventory.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the State of California to cause
reproductive toxicity.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
|