Material Safety Data Sheet
Revision: 01/11/2001
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION DL-alpha-Tocopherol Acetate 22420 None
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Outside USA & Canada 703 527 3887
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Silicon Dioxide 60676-86-0 ~1.5% OSHA R:40 Possible risk of
Pel: 10 irreversible effects
mg/m3 R:20/21/22 Harmful through
8H TWA inhalation, in contact with
ACGIH skin and if swallowed
TLV- S:22 Do not breathe dust
TWA: 0.1 S:24/25 Avoid contact with
mg/m3 skin and eyes
HAZARDS IDENTIFICATION CHIP
For Silicon Dioxide: Carcinogen, Category 3
HCS
For Silicon Dioxide: Group 3 Carcinogen, Irritant
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Decomposition
products may include acrid smoke and irritating fumes.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Store
ambient away from alkalis, strong oxidizing agents and strong acids. Avoid moisture.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the information
contained herein which is offered or your consideration, investigation and verification. Any use of the information contained in this data sheet must be determined by the user
to be in accordance with appropriate applicable regulations.
For Further Asia Pacific Canada Former Soviet Union Japan Norway Spain USA
Information, +852 2811 8693 1 800 463 5800 +7 (095) 232 0250 81 3 5331 9337 63 89 23 10 935 944 950 USB Corporation
contact your (216) 765-5000
local USB Australia Central and East Europe France Latin America Portugal Sweden If purchased from
authorized +61 2 9894 5188 +43 1 982 3826 0169 18 28 00 +55 11 3667 5700 01 417 70 35 018 164000 Amersham Pharmacia
distributor, Biotech use
Amersham Austria Denmark Germany Middle East and Africa South East Asia Switzerland 1 800 526 3593
Pharmacia 01 576 0616 10 +45 4516 2400 07 61 49 03 0 +30 (1) 96 00 687 60 3 724 2080 01 802 81 50
Biotech
Belgium Finland Italy Netherlands South East Europe UK
0800 73888 358 (9) 512 3940 02 27322 1 0165 580 410 +43 (1) 982 3826 0800 515313
MSDS information may be continued on back of page.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: White to off-white, free flowing powder standardized with cornstarch, gelatin and silicon dioxide.
PROPERTIES Boiling Point: No data available Percent Volatile: No data available
Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Insoluble Specific Gravity: 0.9533
Chemical formula: C31-H52-O3 Evaporation Rate: No data available
STABILITY AND REACTIVITY Product is stable. Avoid moisture. Incompatible with alkalis, strong oxidizing agents and strong acids.
Decomposition products may include acrid smoke and irritating fumes. Hazardous polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Contact may cause irritation.
SKIN: Contact may cause irritation and/or allergic reaction.
INHALATION: May cause irritation to upper respiratory system. Prolonged inhalation exposure may cause
silicosis, although percentage of SiO2 present in the mixture is low.
INGESTION: Chronic ingestion or excessive dosage may cause irritation of the mouth, throat, esophagus and
gastrointestinal tract. Silicon Dioxide is listed as a group 3 carcinogen by IARC.
ADDITIONAL INFORMATION:
The toxicological properties of this compound have not been thoroughly investigated. Possibly toxic via oral,
inhalation or absorption.
Tumorigenic and toxicity data listed in RTECS under VV7328000.
Intraperitoneal Rat LDLo = 400 mg/kg (1954) Toxic effects may included, diarrhea, tremor, convulsions,
somnolence and muscle weakness.
Carcinogenicity data:
IARC Cancer Review: Animal - Inadequate Evidence (1997).
Human -Inadequate Evidence (1997).
Group 3 - Agent is not classifiable as to its carcinogenicity to humans (1997).
Tumorigenic data: Equivocal tumorigenic agent by RTECS criteria (1954).
Definition(s):
ACGIH = American Conference of Governmental Industrial Hygienists.
OSHA = Occupational Safety and Health Administration.
IARC = International Agency for Research on Cancer.
NTP = National Toxicology Program Annual Report on Carcinogens.
NIOSH = National Institute for Occupational Safety and Health.
RTECS = Registry of Toxic Effects of Chemical Substances.
ECOLOGICAL INFORMATION No information available
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - No applicable information.
SARA 313 - No applicable information.
EPA TSCA Section 8(b) - Chemical Inventory.
Exposure Limits - ACGIH TLV-TWA: 0.1 mg/m3, respirable dust.
OSHA PEL (Gen Indu): 8H TWA 10 mg/m3/ (% resp SiO2+2).
NIOSH REL to Silica, fused-air: 10H CA TWA 0.05 mg/m3.
California Proposition 65 - No applicable information.
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