Material Safety Data Sheet
Revision: 03/03/2003
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
SUBSTANCE/PREPARATION Colchicine 13805 200-598-5
AND COMPANY
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Outside USA & Canada 703 527 3887
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
Colchicine 64-86-8 ~100% --- R:26/28 Very toxic by
inhalation and if swallowed.
S:13 Keep away from food,
drink and animal feeding stuffs.
S:45 In case of accident or if
you feel unwell, seek medical
advice immediately (show label
where possible).
HAZARDS IDENTIFICATION CHIP
Very Toxic
HCS
Highly Toxic
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Emits toxic fumes
under fire conditions. NFPA Rating: H=4 F=1 R=0.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and
NIOSH-approved respirator. Collect in a manner that does not create dust and place in a suitable waste
container. Avoid contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and
NIOSH-approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Store
ambient way from strong oxidizing agents and protected from light.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety goggles, gloves and
NIOSH-approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection.
Use respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of
material with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust,
vapors or mists. Access to a safety shower and eye-wash. HMIS Rating: H=4 F=1 R=0.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the information
contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet must be determined by the user
to be in accordance with appropriate applicable regulations.
For Further Asia Pacific Canada Former Soviet Union Japan Norway Spain USA
Information, +852 2811 8693 1 800 463 5800 +7 (095) 232 0250 81 3 5331 9337 63 89 23 10 935 944 950 USB Corporation
contact your (216) 765-5000
local USB Australia Central and East Europe France Latin America Portugal Sweden If purchased from
authorized +61 2 9894 5188 +43 1 982 3826 0169 18 28 00 +55 11 3667 5700 01 417 70 35 018 164000 Amersham
distributor, Biosciences use
Amersham Austria Denmark Germany Middle East and Africa South East Asia Switzerland 1 800 526 3593
Biosciences 01 576 0616 10 +45 4516 2400 07 61 49 03 0 +30 (1) 96 00 687 60 3 724 2080 01 802 81 50
Belgium Finland Italy Netherlands South East Europe UK
0800 73888 358 (9) 512 3940 02 27322 1 0165 580 410 +43 (1) 982 3826 0800 515313
MSDS information may be continued on back of page.
PHYSICAL AND CHEMICAL Appearance: White to pale yellow powder Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical formula: C22-H25-N-O6 Melting Point: 142-150掳C
STABILITY AND REACTIVITY Product is stable. Incompatible with strong oxidizing agents. Thermal decomposition may produce carbon
monoxide, carbon dioxide and nitrogen oxides. Darkens on exposure to light. Protect from light. Hazardous
polymerization will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE:
EYES: Causes severe eye irritation.
SKIN: May cause skin irritation. May be harmful if absorbed through the skin.
INHALATION: May be fatal if inhaled. Material may cause irritation to mucous membranes and upper
respiratory tract. Symptoms may include coughing, shortness of breath and chest pain. Other symptoms
may parallel those from ingestion.
INGESTION: May be fatal if swallowed. Chronic ingestion or excessive dosage may cause irritation or burns of
the mouth, throat, esophagus and gastrointestinal tract. Exposure may result in nausea, vomiting, intense
diarrhea, abdominal pain, delirium, hypotension, hypertension, renal failure, convulsions and respiratory
failure or coma progressing to cardiovascular collapse, shock and death. May cause anemia and other blood
abnormalities.
TARGET ORGAN(S): Liver, Kidneys and Bone Marrow.
ADDITIONAL INFORMATION:
May cause kidney damage. May cause bone marrow abnormalities with damage to blood forming tissues. May
cause birth defects based on animal data. May affect reproductive system.
Irritation, reproductive effects, mutation and toxicity data listed in RTECS under GH0700000
Irritation data: Eye Rabbit 1%/3D = Severe.
Toxicity data: Oral Human (woman) LDLo = 3 mg/kg (1948). Oral Mouse LD50 = 5886 ug/kg (1986). Toxic
effects included tremors, muscle weakness, gastrointestinal hyper motility, diarrhea, convulsions,
hallucinations, metabolic acidosis, increased pulse rate, dyspnea, aplastic anemia, nausea and vomiting.
Reproductive: Effects on embryo or fetus - fetal death (1968).
Specific developmental abnormalities - musculoskeletal system, central nervous system,
eye/ear, body wall and craniofacial. (1978).
Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of
Implants)(1989).
Definitions: RTECS = Registry of Toxic Effects of Chemical Substances.
ECOLOGICAL INFORMATION No information available
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION Toxic solid, organic, n.o.s. (Colchicine), class 6.1, UN2811, PGII, Label: Toxic, 6.1
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - TPQ = 10/10,000 lbs; RQ = 10 lbs (revised TPQ based on new or re-evaluated toxicity data).
SARA 313 - This product is subject to SARA Section 313 reporting requirements.
EPA TSCA Section 8(b) - Chemical Inventory.
Exposure Limits - Not established.
California Proposition 65 - This product is or contains chemical(s) known to the State of California to cause
birth defects or reproductive harm.
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