Material Safety Data Sheet
Revision: 10/13/2004
Hazard information is provided for compliance with both the UK Chemicals
(Hazard Information and Packaging) (CHIP) Regulations and the US Hazard
Communication Standard (HCS)
IDENTIFICATION OF THE PRODUCT NAME: PRODUCT CODE: EEC NUMBER:
"-N-Benzoyl-DL-Arginine-B-
SUBSTANCE/PREPARATION 11940 201-781-2
AND COMPANY Naphthylamide Hydrochloride
SUPPLIER: Emergency Contact:
USB Corporation, 26111 Miles Road, Cleveland, Ohio 44128 Phone: (216) 765-5000 Chemtrec (800) 424-9300
Please visit our website at www.usbweb.com for contact information on USB Outside USA & Canada 703 527 3887
product distributors within your area.
COMPOSITION/
HAZARDOUS COMPONENTS HAZARD CAS NO. %WT TLV CHIP R & S Phrases
"-N-Benzoyl-DL-Arginine-B- 913-04-2 ~100% 鈥? R:40 Possible risk of irreversible
Naphthylamide Hydrochloride effects.
R:36/37/38 Irritating to eyes
respiratory system and skin.
S:22 Do not breathe dust.
S:24/25 Avoid contact with skin
and eyes.
S:36/37 Wear suitable protective
clothing and gloves.
HAZARDS IDENTIFICATION CHIP
Harmful
HCS
Irritant
FIRST-AID MEASURES EYES: Flush with water for 15 minutes. Seek medical advice if irritation persists.
SKIN: Flush with water, then wash thoroughly with soap and water. Remove contaminated clothing and wash
before reuse. Seek medical attention if irritation persists.
INHALATION: Remove the victim from exposure and move to fresh air. If breathing is difficult, give oxygen. If
not breathing, give artificial respiration. Keep victim quiet and warm. Seek immediate medical attention.
INGESTION: Drink water and seek immediate medical attention. Avoid alcoholic beverages. Never give
anything by mouth to an unconscious person.
FIRE-FIGHTING INFORMATION Use media suitable to extinguish the supporting or surrounding fire. Wear NIOSH (or equivalent) approved self
contained breathing apparatus. For small fires only: use carbon dioxide, dry powder or foam. Dust/air mixtures may
ignite or explode. Contact with water or moist air may generate flammable and/or toxic gases or vapors.
Flash Point = No data available.
ACCIDENTAL RELEASE MEASURES Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. Collect in a manner that does not create dust and place in a suitable waste container. Avoid
contact of material with skin or eyes. Use adequate ventilation.
HANDLING AND STORAGE Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. Avoid contact of material with skin or eyes. Use adequate ventilation. Dust/air mixtures may
ignite or explode. Store at -20掳C away from incompatible materials.
PERSONAL PROTECTION Wear appropriate personal protective equipment and clothing including lab coat, safety glasses, gloves and NIOSH-
approved respirator. A qualified industrial hygienist should evaluate the need for respiratory protection. Use
respiratory protection approved by NIOSH (or equivalent) and appropriate to the hazard. Avoid contact of material
with skin or eyes. Mechanical ventilation or local exhaust as needed to control exposure to dust, vapors or mists.
Access to a safety shower and eye-wash.
PHYSICAL AND CHEMICAL Appearance: White crystalline powder Boiling Point: No data available
PROPERTIES Vapor Pressure: No data available Vapor Density: No data available
Solubility (Water): Soluble Specific Gravity: No data available
Percent Volatile: No data available Evaporation Rate: No data available
Chemical formula: C23-H25-N5-O2@HCl Melting Point: 194-198掳C
MSDS information may be continued on back of page.
STABILITY AND REACTIVITY Product is stable. Dust/air mixtures may ignite or explode. Contact with water or moist air may generate flammable
and/or toxic gases or vapors. May hydrolyze on contact with moisture to produce $-Naphthylamine which is
carcinogenic and produces cystitis. Handle with caution. Incompatible strong oxidizing agents. Hazardous
decomposition products include carbon and nitrogen oxides and hydrogen chloride gas. Hazardous polymerization
will not occur.
TOXICOLOGICAL INFORMATION EFFECTS OF OVEREXPOSURE: To the best of our knowledge the chemical, physical and toxicological properties
have not been thoroughly investigated.
EYES: Contact may cause irritation and slight corneal injury.
SKIN: Contact may cause irritation and/or allergic reaction.
INHALATION: Material may be irritating to mucous membranes and upper respiratory tract.
INGESTION: May cause irritation of the mouth, throat, esophagus and digestive tract.
ADDITIONAL INFORMATION:
May be harmful by inhalation, ingestion or skin absorption. May hydrolyze on contact with moisture to produce $-
Naphthylamine which is carcinogenic and produces cystitis. Prolonged or repeated exposure to the hydrolysis
product $-Naphthylamine may cause hemorrhagic cystitis and tumors of the bladder and liver. Oral administration
of $-Naphthylamine resulted in the production of bladder cancers in dogs, monkeys and hamsters and liver cancer
in mice. Epidemiological studies have shown that occupational exposure to $-Naphthylamine is strongly associated
with the occurrence of bladder cancer.
The following data is for $-Naphthylamine only: Only select RTECS information is provided here. Please see actual
RTECS entries for complete information.
Tumorigenic, mutation and toxicity data listed for $-Naphthylamine in RTECS under QM2100000.
Oral Rat LD50 = 727 mg/kg (1986). Details of toxic effects not reported other than lethal dose value.
Tumorigenic data: neoplastic by RTCES citeria (1978-87).
carcinogenic by RTECS criteria (1966).
equivocal tumorigenic agent by RTCES criteria (1947).
Carcinogenic data: IARC Cancer Review: Human Sufficient Evidence (1972).
IARC Cancer Review: Animal Sufficient Evidence (1974).
IARC Cancer Review: Group 1 - Known Human Carcinogen (1979).
OSHA - cancer suspect agent (1987)
ACGIH TLV - Confirmed Human Carcinogen (1996).
NTP 10th Report on Carcinogens, 2000: Known to be human carcinogens.
Definition(s): OSHA = Occupational Safety and Health Administration.
IARC = International Agency for Research on Cancer.
RTECS = Registry of Toxic Effects of Chemical Substances.
NTP = National Toxicology Program Annual Report on Carcinogens.
ACGIH = American Conference of Governmental Industrial Hygienists.
ECOLOGICAL INFORMATION No information available.
DISPOSAL CONSIDERATIONS Dispose of material in accordance with applicable local, state, and federal regulations.
TRANSPORTATION INFORMATION US DOT / IATA: No applicable information.
REGULATORY INFORMATION RCRA - No applicable information.
SARA 302 - This material does not have an RQ or TPQ.
SARA 313 - This material is not reportable under 313.
EPA TSCA Section 8(b) - Chemical Inventory.
Exposure Limits - Not established.
California Proposition 65 - No applicable information.
This data sheet is based upon information believed to be reliable. The Company makes no statement or warranty as to the accuracy or completeness of the
information contained herein which is offered for your consideration, investigation and verification. Any use of the information contained in this data sheet
must be determined by the user to be in accordance with appropriate applicable regulations.
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