SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 04/11/2004
Version 1.5
Section 1 - Product and Company Information
Product Name 1,2-DICHLOROETHANE, ANHYDROUS,
99.8%
Product Number 284505
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
1,2-DICHLOROETHANE 107-06-2 Yes
Formula C2H4Cl2
Synonyms Aethylenchlorid (German) * 1,2-Bichloroethane *
Bichlorure d'ethylene (French) * Borer sol *
Brocide * Chlorure d'ethylene (French) * Cloruro
di ethene (Italian) * 1,2-DCE * Destruxol
borer-sol * 1,2-Dichloorethaan (Dutch) *
1,2-Dichlor-aethan (German) * Dichloremulsion *
1,2-Dichlorethane * Di-chlor-mulsion *
Dichloro-1,2-ethane (French) *
alpha,beta-Dichloroethane * sym-Dichloroethane *
1,2-Dichloroethane (OSHA) * 1,2-Dicloroetano
(Italian) * Dutch liquid * Dutch oil * EDC * ENT
1,656 * Ethane dichloride * Ethyleendichloride
(Dutch) * Ethylene chloride * Ethylene dichloride
(ACGIH:OSHA) * 1,2-Ethylene dichloride * Glycol
dichloride * NCI-C00511 * RCRA waste number U077
RTECS Number: KI0525000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Toxic.
May cause cancer. Also harmful if swallowed. Harmful by
inhalation. Irritating to respiratory system and skin. Risk of
serious damage to eyes.
Probable Carcinogen (US). Target organ(s): Heart. Nerves. Calif.
Prop. 65 carcinogen.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
FLASH POINT
55.4 藲F 13 藲C Method: closed cup
EXPLOSION LIMITS
Lower: 6.2 % Upper: 15.6 %
AUTOIGNITION TEMP
413 藲C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
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PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat, sparks, and
open flame. Store under nitrogen.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator in nonventilated areas
and/or for exposure above the TLV or PEL.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 10 PPM
USA MSHA Standard-air TWA 50 PPM (200 MG/M3)
USA OSHA. PEL 8H TWA 50 PPM;CL 100 PPM;PK 20
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 1 PPM
STEL 2 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 50 mg/m3
Poland NDSCh -
Poland NDSP
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
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Molecular Weight 98.96 AMU
pH N/A
BP/BP Range 82 - 84 藲C
MP/MP Range -35 藲C
Freezing Point N/A
Vapor Pressure 87 mmHg 25 藲C
Vapor Density 3.4 g/l
Saturated Vapor Conc. N/A
SG/Density 1.253 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 55.4 藲F 13 藲C Method: closed cup
Explosion Limits Lower: 6.2 %
Upper: 15.6 %
Flammability N/A
Autoignition Temp 413 藲C
Refractive Index 1.444
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Harmful if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Heart. Central nervous system. Liver. Kidneys. Pancreas.
SIGNS AND SYMPTOMS OF EXPOSURE
A simple asphyxiant, exposure can cause anesthetic action,
difficulty in breathing, headache, and dizziness. Prolonged or
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repeated contact with skin can cause defatting and dermatitis.
Contact with eyes can cause redness, tearing, and blurred
vision. Ingestion may cause gastrointestinal irritation. CNS
depression. Paresthesia. Somnolence. Convulsions.
Conjunctivitis. Pulmonary edema. Effects may be delayed.
Irregular breathing. Ingestion can cause gastrointestinal
disorders, nausea, and vomiting. Increased liver enzymes.
Weakness. Heavy or prolonged skin exposure may result in the
absorption of harmful amounts of material. Drowsiness.
TOXICITY DATA
Oral
Human
286 mg/kg
LDLO
Remarks: Gastrointestinal:Ulceration or bleeding from stomach.
Gastrointestinal:Nausea or vomiting. Liver:Fatty liver
degeneration.
Oral
Man
714 mg/kg
LDLO
Remarks: Behavioral:Somnolence (general depressed activity).
Cardiac: Change in rate. Lungs, Thorax, or Respiration:Cyanosis.
Oral
Rat
670 mg/kg
LD50
Inhalation
Rat
1,000 ppm
LC50
Remarks: Behavioral:Coma. Lungs, Thorax, or
Respiration:Cyanosis. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
Intraperitoneal
Rat
807 MG/KG
LD50
Subcutaneous
Rat
1 GM/KG
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:General anesthetic.
Behavioral:Ataxia.
Oral
Mouse
413 mg/kg
LD50
Remarks: Lungs, Thorax, or Respiration:Other changes.
Liver:Other changes.
Intraperitoneal
Mouse
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470 MG/KG
LD50
Oral
Dog
5700 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:General anesthetic.
Behavioral:Ataxia.
Inhalation
Monkey
3,000 ppm
LC50
Oral
Rabbit
860 mg/kg
LD50
Skin
Rabbit
2800 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:General anesthetic.
Behavioral:Ataxia.
IRRITATION DATA
Skin
Rabbit
625 mg
Remarks: Open irritation test
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
63 mg
Remarks: Severe irritation effect
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 5286 MG/KG
Exposure Time: 69W
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Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors. Skin and Appendages: Other: Tumors.
Species: Rat
Route of Application: Inhalation
Dose: 5 PPM
Exposure Time: 7H/78W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Blood:Leukemia Skin and Appendages: Other: Tumors.
Species: Mouse
Route of Application: Oral
Dose: 3536 MG/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors. Skin and Appendages: Other:
Tumors.
Species: Mouse
Route of Application: Inhalation
Dose: 5 PPM
Exposure Time: 7H/78W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Skin and
Appendages: Other: Tumors.
Species: Mouse
Route of Application: Skin
Dose: 1120 GM/KG
Exposure Time: 74W
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Skin and Appendages: Other: Tumors.
Species: Rat
Route of Application: Oral
Dose: 38 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Vascular:Tumors. Gastrointestinal:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 76 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic Effects: Uterine tumors
Species: Rat
Route of Application: Oral
Dose: 18 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Vascular:Tumors. Gastrointestinal:Tumors.
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Species: Mouse
Route of Application: Oral
Dose: 38 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic Effects: Uterine tumors
IARC CARCINOGEN LIST
Rating: Group 2B
NTP CARCINOGEN LIST
Rating: Clear evidence.
Species: Mouse/rat
Route: Gavage
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Species: Human
Dose: 5 ML/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Human
Dose: 100 MG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Rat
Route: Oral
Dose: 150 MG/KG
Mutation test: DNA damage
Species: Rat
Route: Inhalation
Dose: 150 PPM
Exposure Time: 6H
Mutation test: DNA damage
Species: Rat
Dose: 130 UMOL/L
Cell Type: liver
Mutation test: Unscheduled DNA synthesis
Species: Mouse
Route: Intraperitoneal
Dose: 300 MG/KG
Mutation test: specific locus test
Species: Mouse
Route: Intraperitoneal
Dose: 2 MMOL/KG
Mutation test: DNA damage
Species: Mouse
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Route: Oral
Dose: 100 MG/KG
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 29 MG/KG
Mutation test: DNA inhibition
Species: Mouse
Dose: 80 MG/KG
Cell Type: S. typhimurium
Mutation test: Body fluid assay
Species: Hamster
Dose: 2 MMOL/L (+S9)
Cell Type: ovary
Mutation test: Mutation in microorganisms
Species: Hamster
Dose: 200 UL/PLATE
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 1 GM/L
Cell Type: lung
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 40 MMOL/L
Cell Type: ovary
Mutation test: Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 300 PPM/7H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 208 MG/M3/6H
Route of Application: Inhalation
Exposure Time: (2W PRE/1-21D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 225 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
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Time: 24 h
Value: 540 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Ethylene dichloride
UN#: 1184
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Ethylene dichloride
IATA UN Number: 1184
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F T
Indication of Danger: Highly Flammable. Toxic.
R: 45 11 22 36/37/38
Risk Statements: May cause cancer. Highly flammable. Also
harmful if swallowed. Irritating to eyes, respiratory system and
skin.
S: 53 45
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Toxic.
Risk Statements: May cause cancer. Also harmful if swallowed.
Harmful by inhalation. Irritating to respiratory system and
skin. Risk of serious damage to eyes.
Safety Statements: Keep away from sources of ignition - no
smoking. In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice. Restricted to
professional users. Attention - Avoid exposure - obtain special
instructions before use. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
US Statements: Probable Carcinogen (US). Target organ(s): Heart.
Nerves. Calif. Prop. 65 carcinogen.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
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DEMINIMIS: 0.1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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