SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/19/2005
Date Updated: 05/24/2004
Version 1.4
Section 1 - Product and Company Information
Product Name CYCLOHEXANOL
Product Number 29105
Brand FLUKA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
CYCLOHEXANOL 108-93-0 Yes
Formula C6H12O
Synonyms Adronal * Anol * Cicloesanolo (Italian) *
Cyclohexanol (ACGIH:OSHA) * Cyclohexyl alcohol *
Cykloheksanol (Polish) * Hexahydrophenol *
Hexalin * Hydralin * Hydrophenol *
Hydroxycyclohexane * Naxol * Phenol, hexahydro-
RTECS Number: GV7875000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful by inhalation and if swallowed. Irritating to respiratory
system and skin.
Combustible. Target organ(s): Liver. Kidneys.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 2
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 2
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
154.4 掳F 68 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 1.25 % Upper: 12.25 %
AUTOIGNITION TEMP
300 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat, sparks, and
open flame.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 50 PPM
Remarks: Skin
USA MSHA Standard-air TWA 50 PPM (200 MG/M3)
USA OSHA. PEL 8H TWA 50 PPM (200 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 50 PPM (SK)
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh -
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
Molecular Weight 100.16 AMU
pH 6.5 20 掳C Concentration: 40
g/l
BP/BP Range 66 - 68 掳C 11 mmHg
MP/MP Range 22 掳C
Freezing Point N/A
Vapor Pressure 0.98 mmHg 25 掳C
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
SG/Density 0.947 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity 0.012 Pas
Surface Tension N/A
Partition Coefficient Log Kow: 1.25 25 掳C
Decomposition Temp. N/A
Flash Point 154.4 掳F 68 掳C Method: closed cup
Explosion Limits Lower: 1.25 %
Upper: 12.25 %
Flammability N/A
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Autoignition Temp 300 掳C
Refractive Index 1.466
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Liver. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged exposure can cause: Headache. Nausea. Tremors.
Incoordination. Symptoms of exposure may include burning
sensation, coughing, wheezing, laryngitis, shortness of breath,
headache, nausea, and vomiting. To the best of our knowledge,
the chemical, physical, and toxicological properties have not
been thoroughly investigated.
TOXICITY DATA
Skin
Rabbit
> 1,000 mg/kg
LD50
4H
Inhalation
Rat
> 3.6 ppm
LC50
Oral
Rat
1400 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Other changes. Nutritional and
Gross Metabolic:Weight loss or decreased weight gain.
Intraperitoneal
Mouse
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1352 MG/KG
LD50
Intravenous
Mouse
272 MG/KG
LD50
Intramuscular
Mouse
1 GM/KG
LD50
IRRITATION DATA
Eyes
Human
100 ppm
Skin
Rabbit
0.5 ml
24H
Remarks: Moderate irritation effect
Skin
Rabbit
0.5 ml
24H
Remarks: Mild irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Mild irritation effect
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 100 UMOL/L
Cell Type: leukocyte
Mutation test: Cytogenetic analysis
Species: Mammal
Dose: 150 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 315 MG/KG
Route of Application: Subcutaneous
Exposure Time: (21D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
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material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects:
Prostate, seminal vessicle, Cowper's gland, accessory glands.
Species: Gerbil
Dose: 315 MG/KG
Route of Application: Subcutaneous
Exposure Time: (21D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects:
Prostate, seminal vessicle, Cowper's gland, accessory glands.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 705 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: > 500 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 29.2 mg/l
ELIMINATION
Elimination: 97 %
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Combustible liquid, n.o.s.
UN#: NA1993
Class: COMBUSTIBLE LIQUID
Packing Group: Packing Group III
Hazard Label: None
PIH: Not PIH
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn
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Indication of Danger: Harmful.
R: 20/22 37/38
Risk Statements: Harmful by inhalation and if swallowed.
Irritating to respiratory system and skin.
S: 24/25
Safety Statements: Avoid contact with skin and eyes.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful by inhalation and if swallowed.
Irritating to respiratory system and skin.
Safety Statements: Avoid contact with skin and eyes. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice.
US Statements: Combustible. Target organ(s): Liver. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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