SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 11/20/2003
Version 1.4
Section 1 - Product and Company Information
Product Name BUTYRIC ACID, 99+%
Product Number B103500
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
BUTYRIC ACID 107-92-6 No
Formula C4H8O2
Synonyms Butanic acid * Butanoic acid * Buttersaeure
(German) * n-Butyric acid * Ethylacetic acid *
Kyselina maselna (Czech) * 1-Propanecarboxylic
acid * Propylformic acid
RTECS Number: ES5425000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Corrosive.
Causes burns.
Readily absorbed through skin. Stench. Target organ(s): Blood.
Combustible.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 2
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
161.6 掳F 72 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 2 % Upper: 10 %
AUTOIGNITION TEMP
440 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
flame. Store in a cool dry place.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Odor: Stench.
Property Value At Temperature or Pressure
Molecular Weight 88.11 AMU
pH 3 20 掳C Concentration: 10
g/l
BP/BP Range 164 掳C 760 mmHg
MP/MP Range -7.9 掳C
Freezing Point N/A
Vapor Pressure 0.43 mmHg 20 掳C
Vapor Density 3.04 g/l
Saturated Vapor Conc. N/A
SG/Density 0.958 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity 1.61 Pas 20 掳C
Surface Tension 26.74 mN/m 20 掳C
Partition Coefficient Log Kow: 0.79
Decomposition Temp. N/A
Flash Point 161.6 掳F 72 掳C Method: closed cup
Explosion Limits Lower: 2 %
Upper: 10 %
Flammability N/A
Autoignition Temp 440 掳C
Refractive Index 1.399
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:50 mg/ml H2O
Other Solvents: ALCOHOL, ETHER
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Can cause CNS depression.
TOXICITY DATA
Oral
Rat
8,790 mg/kg
LD50
Oral
Rat
2,940 mg/kg
LD50
1.4 H
Inhalation
Rabbit
400 mg/m3
Skin
Rabbit
6,083 mg/kg
LD50
Oral
Rat
2000 mg/kg
LD50
Intraperitoneal
Mouse
3180 MG/KG
LD50
Subcutaneous
Mouse
3180 MG/KG
LD50
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Intravenous
Mouse
800 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Skin
Rabbit
530 UL/KG
LD50
IRRITATION DATA
Skin
Rabbit
Remarks: Corrosive.
Eyes
Rabbit
Remarks: Moderate irritation effect
Skin
Rabbit
500 mg
Remarks: Open irritation test
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 3 MMOL/L
Cell Type: HeLa cell
Mutation test: DNA damage
Species: Human
Dose: 4 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Chicken
Dose: 2 MMOL/L
Cell Type: fibroblast
Mutation test: DNA damage
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Time: 72 h
Value: 47 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 61.7 mg/l
Test Type: LC50 Fish
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Species: Leuciscus idus
Time: 48 h
Value: 250 - 480 mg/l
Test Type: LC50 Fish
Species: Cyprinus carpio
Time: 48 h
Value: 65 mg/l
ADDITIONAL RESULTS/DATA FROM RELEVENT SCIENTIFIC EXPERIMENTS
Avoid contamination of the environment
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Butyric acid
UN#: 2820
Class: 8
Packing Group: Packing Group III
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Butyric acid
IATA UN Number: 2820
Hazard Class: 8
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 34
Risk Statements: Causes burns.
S: 26 36 45
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Corrosive.
Risk Statements: Causes burns.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US Statements: Readily absorbed through skin. Stench. Target
organ(s): Blood. Combustible.
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UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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