SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 04/02/2004
Version 1.10
Section 1 - Product and Company Information
Product Name ACETONE, REAGENTPLUS, >=99%
Product Number 179973
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ACETONE 67-64-1 No
Formula C3H6O
Synonyms Aceton (German, Dutch, Polish) * Acetone
(ACGIH:OSHA) * Chevron acetone *
Dimethylformaldehyde * Dimethylketal * Dimethyl
ketone * Ketone, dimethyl * Ketone propane *
beta-Ketopropane * Methyl ketone * Propanone *
2-Propanone * Pyroacetic acid * Pyroacetic ether
* RCRA waste number U002
RTECS Number: AL3150000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Irritant.
Irritating to eyes. Repeated exposure may cause skin dryness or
cracking. Vapors may cause drowsiness and dizziness.
Target organ(s): Liver. Kidneys. Nerves.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
FLASH POINT
1 掳F -17 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 2 % Upper: 13 %
AUTOIGNITION TEMP
465 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
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Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat, sparks, and
open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
SPECIAL PRECAUTIONS
The material may slowly penetrate protective gloves; therefore in
case of spills, discard gloves after use.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 750 PPM
USA ACGIH TWA 500 PPM
USA MSHA Standard-air TWA 1000 PPM (2400 MG/M3)
USA OSHA. PEL 8H TWA 1000 PPM (2400 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 250 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 600 MG/M3
Poland NDSCh 1800 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 58.08 AMU
pH N/A
BP/BP Range 56 掳C 760 mmHg
MP/MP Range -94 掳C
Freezing Point -94.7 掳C
Vapor Pressure 184 mmHg 20 掳C
Vapor Density 2 g/l
Saturated Vapor Conc. N/A
SG/Density 0.79 g/cm3
Bulk Density N/A
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Odor Threshold 100 - 140 ppm
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity 0.303 Pas 25 掳C
Surface Tension 23.2 mN/m 20 掳C
Partition Coefficient Log Kow: -0.24
Decomposition Temp. N/A
Flash Point 1 掳F -17 掳C Method: closed cup
Explosion Limits Lower: 2 %
Upper: 13 %
Flammability N/A
Autoignition Temp 465 掳C
Refractive Index 1.359
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:miscible
Other Solvents: MISCIBLE WITH ALCOHOL, DMF
CHLOROFORM, ETHER
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Bases, Oxidizing agents, Reducing agents
Acetone reacts violently with phosphorous oxychloride.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SENSITIZATION
Sensitization: Causes dermatitis.
TARGET ORGAN(S) OR SYSTEM(S)
Liver. Kidneys.
TOXICITY DATA
Oral
Rat
5800 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Tremor.
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Inhalation
Rat
50,100 mg/m3
LC50
Intravenous
Rat
5500 MG/KG
LD50
Oral
Mouse
3000 mg/kg
LD50
Inhalation
Mouse
44,000 mg/m3
LC50
Intraperitoneal
Mouse
1297 MG/KG
LD50
Oral
Rabbit
5340 mg/kg
LD50
Skin
Guinea pig
>9400 UL/KG
LD50
IRRITATION DATA
Eyes
Human
500 ppm
Skin
Rabbit
395 mg
Remarks: Open irritation test
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
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CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - MUTAGEN
Species: Hamster
Dose: 40 GM/L
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 273 GM/KG
Route of Application: Oral
Exposure Time: (13W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mammal
Dose: 31500 UG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 5,540 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 13,500 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Acetone
UN#: 1090
Class: 3
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Packing Group: Packing Group II
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Acetone
IATA UN Number: 1090
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F Xi
Indication of Danger: Highly Flammable. Irritant.
R: 11 36 66 67
Risk Statements: Highly flammable. Irritating to eyes. Repeated
exposure may cause skin dryness or cracking. Vapors may cause
drowsiness and dizziness.
S: 9 16 26
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Irritant.
Risk Statements: Irritating to eyes. Repeated exposure may cause
skin dryness or cracking. Vapors may cause drowsiness and
dizziness.
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice.
US Statements: Target organ(s): Liver. Kidneys. Nerves.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
ALDRICH - 179973 www.sigma-aldrich.com Page 7
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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