SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 04/07/2004
Version 1.4
Section 1 - Product and Company Information
Product Name ACETIC ANHYDRIDE, REAGENTPLUSTM,
>=99%
Product Number 320102
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ACETIC ANHYDRIDE 108-24-7 No
Formula C4H6O3
Synonyms Acetanhydride * Acetic acid, anhydride (9CI) *
Acetic anhydride (ACGIH:OSHA) * Acetic oxide *
Acetyl anhydride * Acetyl ether * Acetyl oxide *
Anhydride acetique (French) * Anhydrid kyseliny
octove (Czech) * Anidride acetica (Italian) *
Azijnzuuranhydride (Dutch) * Essigsaeureanhydrid
(German) * Ethanoic anhydrate * Octowy bezwodnik
(Polish)
RTECS Number: AK1925000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Combustible (USA) Flammable (EU). Corrosive.
Reacts violently with water. Harmful by inhalation and if
swallowed. Causes burns.
Lachrymator.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 2
SPECIAL HAZARD(S): Water reactive
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 2
SPECIAL HAZARD(S): Water reactive
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
120.2 掳F 49 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 2.7 % Upper: 10.3 %
AUTOIGNITION TEMP
332 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with an activated carbon adsorbent, take up and place in
closed containers. Transport outdoors. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
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skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
flame. Store in a cool dry place.
SPECIAL REQUIREMENTS
Reacts violently with water.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 5 PPM
USA MSHA Standard Ceiling co5 PPM (20 MG/M3)
USA OSHA. PEL 8H TWA 5 PPM (20 MG/M3)
USA NIOSH Ceiling co5 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh -
Poland NDSP 20 MG/M3
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Odor: Pungent Acrid
Property Value At Temperature or Pressure
Molecular Weight 102.09 AMU
pH N/A
BP/BP Range 138 - 140 掳C 760 mmHg
MP/MP Range -73 掳C
Freezing Point N/A
Vapor Pressure 4 mmHg 20 掳C
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
SG/Density 1.08 g/cm3
Bulk Density N/A
Odor Threshold 0.117 ppm
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity 0.91 Pas 20 掳C
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Surface Tension 32.7 mN/m 20 掳C
Partition Coefficient N/A
Decomposition Temp. 136 掳C
Flash Point 120.2 掳F 49 掳C Method: closed cup
Explosion Limits Lower: 2.7 %
Upper: 10.3 %
Flammability N/A
Autoignition Temp 332 掳C
Refractive Index 1.39
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
Other Solvents: BENZENE, CHLOROFORM
MISCIBLE WITH ALCOHOL, ETHER AC
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Do not allow water to enter container because
of violent reaction.
Materials to Avoid: Alcohols, Acids, Oxidizing agents, Bases,
Reducing agents, Finely powdered metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
TOXICITY DATA
Oral
Rat
1780 mg/kg
LD50
Inhalation
Rat
1,000 ppm
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LC50
Skin
Rabbit
4 ML/KG
LD50
IRRITATION DATA
Skin
Rabbit
Remarks: Mild irritation effect
Eyes
Rabbit
Remarks: Severe irritation effect
Skin
Rabbit
540 mg
Remarks: Open irritation test
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Time: 24 h
Value: 200 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 96 h
Value: 55 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 48 h
Value: 265 - 279 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Acetic anhydride
UN#: 1715
Class: 8
Packing Group: Packing Group II
Hazard Label: Corrosive
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Acetic anhydride
IATA UN Number: 1715
Hazard Class: 8
Packing Group: II
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Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 10 20/22 34
Risk Statements: Flammable. Harmful by inhalation and if
swallowed. Causes burns.
S: 26 36/37/39 45
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Combustible (USA) Flammable (EU).
Corrosive.
Risk Statements: Reacts violently with water. Harmful by
inhalation and if swallowed. Causes burns.
Safety Statements: Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible). In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice.
US Statements: Lachrymator.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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