SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/20/2005
Date Updated: 04/04/2004
Version 1.4
Section 1 - Product and Company Information
Product Name BORIC ACID, REAGENTPLUS, 99.995%
Product Number 470856
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
BORIC ACID 10043-35-3 No
Formula H3BO3
Synonyms Basilit B * Boracic acid * Borofax * Boron
trihydroxide * Borsaure (German) * Dr.'s 1 Flea
Terminator DF * Dr.'s 1 Flea Terminator DFPBO *
Dr.'s 1 Flea Terminator DT * Dr.'s 1 Flea
Terminator DTPBO * Flea Prufe * NCI-C56417 *
Orthoboric acid * Super Flea Eliminator * Three
elephant * Trihydroxyborone
RTECS Number: ED4550000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Caution: Avoid contact and inhalation. Target organ(s): Testes.
HMIS RATING
HEALTH: 1*
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 1
FLAMMABILITY: 0
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid inhalation. Avoid contact with eyes, skin,
and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory: Wear dust mask.
Hand: Protective gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 61.83 AMU
pH 5.1 Concentration: 1.8 g/l
BP/BP Range 300 掳C
MP/MP Range 160 掳C
Freezing Point N/A
Vapor Pressure 2.6 mmHg 20 掳C
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.44 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Potassium, Acid anhydrides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Boron oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
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Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Testes.
SIGNS AND SYMPTOMS OF EXPOSURE
Toxicity reported for borates in humans: ingestion or absorption
may cause nausea, vomiting, diarrhea, abdominal cramps,
anderythematous lesions on the skin and mucous membranes. Other
symptoms include: circulatory collapse, tachycardia, cyanosis,
delirium, convulsions, and coma. Death has been reported to
occur in infants from less than 5 grams and in adults from 5 to
20 grams.
TOXICITY DATA
Oral
Man
429 mg/kg
LDLO
Remarks: Cardiac:Other changes. Kidney, Ureter, Bladder:Changes
in tubules (including acute renal failure, acute tubular
necrosis).
Oral
Woman
200 mg/kg
LDLO
Remarks: Behavioral:Fluid intake.
Gastrointestinal:Hypermotility, diarrhea.
Gastrointestinal:Nausea or vomiting.
Oral
Infant
934 mg/kg
LDLO
Skin
Infant
1200 mg/kg
LDLO
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Skin and Appendages:Skin: After systemic exposure: Dermatitis,
other Nutritional and Gross Metabolic:Changes in:Body
temperature increase.
Skin
Child
4000 mg/kg
LDLO
Skin
Man
2430 mg/kg
LDLO
Remarks: Gastrointestinal:Hypermotility, diarrhea. Skin and
Appendages:Skin: After topical exposure:Primary irritation.
Nutritional and Gross Metabolic:Changes in:Body temperature
increase.
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Skin
Child
1500 mg/kg
LDLO
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Lungs, Thorax, or
Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
Subcutaneous
Infant
1100 MG/KG
LDLO
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
Oral
Rat
2660 mg/kg
LD50
Subcutaneous
Rat
1400 MG/KG
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
Intravenous
Rat
1330 MG/KG
LD50
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
Oral
Mouse
3450 mg/kg
LD50
Subcutaneous
Mouse
1740 MG/KG
LD50
Intravenous
Mouse
1240 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Respiratory depression.
Gastrointestinal:Hypermotility, diarrhea.
Subcutaneous
Guinea pig
1200 MG/KG
LD50
Remarks: Behavioral:Tremor. Gastrointestinal:Hypermotility,
diarrhea. Gastrointestinal:Nausea or vomiting.
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IRRITATION DATA
Skin
Human
15 mg
3D
I
Remarks: Mild irritation effect
NTP CARCINOGEN LIST
Rating: No evidence.
Species: Mouse
Route: Feed
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 1600 MG/KG
Route of Application: Oral
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 6600 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Other developmental abnormalities.
Species: Rat
Dose: 1596 MG/KG
Route of Application: Oral
Exposure Time: (0-20D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 7684 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 800 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Cardiovascular (circulatory) system.
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Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Other developmental abnormalities.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat
Dose: 45 GM/KG
Route of Application: Oral
Exposure Time: (90D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 5390 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 52 MG/KG
Route of Application: Oral
Exposure Time: (26W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 9600 UG/M3/4H
Route of Application: Inhalation
Exposure Time: (16W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 17051 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 18054 MG/KG
Route of Application: Oral
Exposure Time: (1-18D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Mouse
Dose: 8136 MG/KG
Route of Application: Oral
Exposure Time: (1-18D PREG)
Result: Maternal Effects: Other effects. Effects on Embryo or
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Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Specific Developmental Abnormalities:
Cardiovascular (circulatory) system.
Species: Rabbit
Dose: 3500 MG/KG
Route of Application: Oral
Exposure Time: (7-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rabbit
Dose: 1750 MG/KG
Route of Application: Oral
Exposure Time: (7-20D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Other effects.
Section 12 - Ecological Information
N/A
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 133 mg/l
Test Type: LC0 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: > 1,021 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
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transport.
Section 15 - Regulatory Information
US CLASSIFICATION AND LABEL TEXT
US Statements: Caution: Avoid contact and inhalation. Target
organ(s): Testes.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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