SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 04/11/2004
Version 1.6
Section 1 - Product and Company Information
Product Name TERT-BUTANOL, REAGENTPLUS, >=99.3%
(TEBOL 99)
Product Number B85927
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
2-METHYL-2-PROPANOL 75-65-0 Yes
Formula C4H10O
Synonyms Alcool butylique tertiaire (French) * Arconol *
t-Butanol * tert-Butanol * Butanol tertiaire
(French) * tert-Butyl alcohol (OSHA) * t-Butyl
hydroxide * 1,1-Dimethylethanol * Methanol,
trimethyl- * 2-Methyl-2-propanol *
2-Methylpropan-2-ol * NCI-C55367 * 2-Propanol,
2-methyl- * Trimethylcarbinol * Trimethyl methanol
RTECS Number: EO1925000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Harmful.
Harmful by inhalation. Risk of serious damage to eyes.
Target organ(s): Central nervous system. Kidneys.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion can occur under fire conditions.
In advanced or massive fires the area should be evacuated and
the fire should be fought from a remote explosion-resistant
location.
FLASH POINT
51.8 掳F 11 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 2.4 % Upper: 8 %
AUTOIGNITION TEMP
480 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Use water spray to cool fire-exposed containers.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Vapor may travel
considerable distance to source of ignition and flash back.
Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
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METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 100 PPM
USA MSHA Standard-air TWA 100 PPM (300 MG/M3)
USA OSHA. PEL 8H TWA 100 PPM (300 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 100 PPM
STEL 150 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 450 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 74.12 AMU
pH N/A
BP/BP Range 82 - 83 掳C
MP/MP Range 25 - 26 掳C
Freezing Point N/A
Vapor Pressure 31 mmHg 20 掳C
Vapor Density 2.5 g/l
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Saturated Vapor Conc. N/A
SG/Density 0.79 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content < 0.1 %
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 51.8 掳F 11 掳C Method: closed cup
Explosion Limits Lower: 2.4 %
Upper: 8 %
Flammability N/A
Autoignition Temp 480 掳C
Refractive Index 1.387
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents Copper, Copper alloys,
Alkali metals, Aluminum.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Peroxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Kidneys. Liver. Bladder. Thyroid.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Exposure can cause: Gastrointestinal
disturbances. Drying, cracking, or irritation of the skin.
TOXICITY DATA
Oral
Rat
2743 mg/kg
LD50
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Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Lungs, Thorax, or
Respiration:Respiratory depression. Gastrointestinal:Other
changes.
Inhalation
Rat
> 10,000 ppm
LC50
Remarks: Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea. Lungs, Thorax, or Respiration:Pulmonary
emboli.
Intraperitoneal
Mouse
399 MG/KG
LD50
Remarks: Liver:Other changes.
Intravenous
Mouse
1538 MG/KG
LD50
Oral
Rabbit
3559 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Cardiac:Pulse rate. Lungs, Thorax, or
Respiration:Dyspnea.
Skin
Rabbit
> 2000 mg/kg
LD50
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
IRRITATION DATA
Skin
Rabbit
0.5 ml
24H
Remarks: Mild irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Severe irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 146 GM/KG
Exposure Time: 2Y
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Frequency: C
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Species: Mouse
Route of Application: Oral
Dose: 1540 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Thyroid tumors.
NTP CARCINOGEN LIST
Rating: Some evidence.
Species: Mouse/rat
Route: Drinking
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 2000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 3500 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Mouse
Dose: 103 GM/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Mouse
Dose: 135 GM/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Mouse
Dose: 20240 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 6,140 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 933 mg/l
Test Type: IC50 Algae
Time: 72 h
Value: > 1,000 mg/l
ELIMINATION
Elimination: 99.9 %
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Butanols
UN#: 1120
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Butanols
IATA UN Number: 1120
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F Xn
Indication of Danger: Highly Flammable. Harmful.
R: 11 20
Risk Statements: Highly flammable. Harmful by inhalation.
S: 9 16
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Harmful.
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Risk Statements: Harmful by inhalation. Risk of serious damage
to eyes.
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear eye/face protection.
US Statements: Target organ(s): Central nervous system. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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