SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/18/2005
Date Updated: 07/01/2004
Version 1.5
Section 1 - Product and Company Information
Product Name CYCLOHEXANE, REAGENTPLUS, >=99%
Product Number C100307
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
CYCLOHEXANE 110-82-7 Yes
Formula C6H12
Synonyms Benzene, hexahydro- * Cicloesano (Italian) *
Cyclohexaan (Dutch) * Cyclohexan (German) *
Cyclohexane (ACGIH:OSHA) * Cykloheksan (Polish) *
Hexahydrobenzene * Hexamethylene * Hexanaphthene
* RCRA waste number U056
RTECS Number: GU6300000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Harmful. Dangerous for the
environment.
Irritating to skin. Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment. Harmful: may
cause lung damage if swallowed. Vapors may cause drowsiness and
dizziness.
Target organ(s): Lungs. Central nervous system.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion can occur under fire conditions.
In advanced or massive fires the area should be evacuated and
the fire should be fought from a remote explosion-resistant
location.
FLASH POINT
-0.4 藲F -18 藲C Method: closed cup
EXPLOSION LIMITS
Lower: 1 % Upper: 9 %
AUTOIGNITION TEMP
260 藲C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Specific Method(s) of Fire Fighting: Use water spray to cool
fire-exposed containers.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
ALDRICH - C100307 www.sigma-aldrich.com Page 2
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame. Store in a cool dry place. Store under nitrogen.
SPECIAL REQUIREMENTS
Store under inert gas.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 300 PPM
USA MSHA Standard-air TWA 300 PPM (1050 MG/M3)
USA OSHA. PEL 8H TWA 300 PPM (1050 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 300 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 1000 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 84.16 AMU
pH N/A
BP/BP Range 80.7 藲C 760 mmHg
ALDRICH - C100307 www.sigma-aldrich.com Page 3
MP/MP Range 6.5 藲C
Freezing Point N/A
Vapor Pressure 77 mmHg 20 藲C
Vapor Density 2.9 g/l
Saturated Vapor Conc. N/A
SG/Density 0.778 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point -0.4 藲F -18 藲C Method: closed cup
Explosion Limits Lower: 1 %
Upper: 9 %
Flammability N/A
Autoignition Temp 260 藲C
Refractive Index 1.426
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Lungs. Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause CNS depression, drowsiness, light-headedness,
and irritability. Damage to the lungs. Gastrointestinal
disturbances. Lung irritation, chest pain, and edema which may
be fatal.
TOXICITY DATA
ALDRICH - C100307 www.sigma-aldrich.com Page 4
Oral
Rat
12705 mg/kg
LD50
Oral
Mouse
813 mg/kg
LD50
Inhalation
Mammal
70,000 mg/m3
LC50
IRRITATION DATA
Skin
Rabbit
1,548 mg
2D
I
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Cyclohexane
UN#: 1145
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Cyclohexane
IATA UN Number: 1145
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F Xn N
Indication of Danger: Highly Flammable. Harmful. Dangerous for
the environment.
R: 11 38 50/53 65 67
Risk Statements: Highly flammable. Irritating to skin. Very
toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment. Harmful: may cause lung damage if
ALDRICH - C100307 www.sigma-aldrich.com Page 5
swallowed. Vapors may cause drowsiness and dizziness.
S: 9 16 33 60 61 62
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. Take
precautionary measures against static discharges. This material
and its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets. If swallowed, do not induce vomiting: seek medical
advice immediately and show this container or label.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Harmful. Dangerous for the environment.
Risk Statements: Irritating to skin. Very toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Harmful: may cause lung damage if swallowed. Vapors
may cause drowsiness and dizziness.
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. Take
precautionary measures against static discharges. This material
and its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets. If swallowed, do not induce vomiting: seek medical
advice immediately and show this container or label.
US Statements: Target organ(s): Lungs. Central nervous system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
ALDRICH - C100307 www.sigma-aldrich.com Page 6
|