SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 06/16/2004
Version 1.11
Section 1 - Product and Company Information
Product Name ACETIC ACID, GLACIAL, 99.99+%
Product Number 338826
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ACETIC ACID 64-19-7 No
Formula C2H4O2
Synonyms Acetic acid (ACGIH:OSHA) * Acetic acid, glacial *
Acide acetique (French) * Acido acetico (Italian)
* Azijnzuur (Dutch) * Essigsaeure (German) *
Ethanoic acid * Ethylic acid * Glacial acetic
acid * Kyselina octova (Czech) *
Methanecarboxylic acid * Octowy kwas (Polish) *
Vinegar acid
RTECS Number: AF1225000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Combustible (USA) Flammable (EU). Corrosive.
Causes severe burns. Harmful in contact with skin.
Lachrymator. Target organ(s): Teeth. Kidneys.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 2
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
104 掳F 40 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 4 % Upper: 19.9 %
AUTOIGNITION TEMP
427 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
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flame.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 15 PPM
USA ACGIH TWA 10 PPM
USA MSHA Standard-air TWA 10 PPM (25 MG/M3)
USA OSHA. PEL 8H TWA 10 PPM (25 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 10 PPM
STEL 15 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 15 MG/M3
Poland NDSCh 30 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 60.05 AMU
pH 2.4 Concentration: 60.05 g/l
BP/BP Range 117 - 118 掳C 760 mmHg
MP/MP Range 16.2 掳C
Freezing Point 16.7 掳C
Vapor Pressure 11.4 mmHg 20 掳C
Vapor Density 2.07 g/l
Saturated Vapor Conc. N/A
SG/Density 1.06 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension 28.8 mN/m 10 掳C
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Partition Coefficient Log Kow: -0.17
Decomposition Temp. N/A
Flash Point 104 掳F 40 掳C Method: closed cup
Explosion Limits Lower: 4 %
Upper: 19.9 %
Flammability N/A
Autoignition Temp 427 掳C
Refractive Index 1.3715
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: MISCIBLE WITH ALCOHOL,
ETHER GLYCEROL, ACETONE, BEN
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Oxidizing agents, Soluble carbonates and
phosphates, Hydroxides, Oxides, Metals, Peroxides, Permanganates,
Amines, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Teeth. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Ingestion or inhalation of concentrated acetic acid
causes damage to tissues of the respiratory and digestive
tracts. Symptoms include: hematemesis, bloody diarrhea, edema
and/or perforation of the esophagus and pylorus, hematuria,
anuria, uremia, albuminuria, hemolysis, convulsions, bronchitis,
pulmonary edema, pneumonia, cardiovascular collapse, shock, and
death. Direct contact or exposure to high concentrations of
vapor with skin or eyes can cause: erythema, blisters, tissue
destruction with slow healing, skin blackening, hyperkeratosis,
fissures, corneal erosion, opacification, iritis,
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conjunctivitis, and possible blindness. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
CONDITIONS AGGRAVATED BY EXPOSURE
Severe, acute pancreatitis may occur after ingestion of
concentrated acetic acid.
TOXICITY DATA
Oral
Rat
3310 mg/kg
LD50
Inhalation
Mouse
5,620 ppm
LC50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Sense Organs and Special
Senses (Nose, Eye, Ear, and Taste):Eye:Other. Blood:Other
changes.
Intravenous
Mouse
525 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Skin
Rabbit
1060 UL/KG
LD50
IRRITATION DATA
Skin
Human
50 mg
24H
Remarks: Mild irritation effect
Skin
Rabbit
525 mg
Remarks: Open irritation test
Skin
Rabbit
50 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
5 mg
30S
Remarks: Rinsed
CHRONIC EXPOSURE - MUTAGEN
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Species: Human
Dose: 5 MMOL/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Skin
Dose: 79279 UG/KG
Mutation test: Unscheduled DNA synthesis
Species: Mouse
Route: Skin
Dose: 1201 MG/KG
Mutation test: Other mutation test systems
Species: Hamster
Dose: 10 MMOL/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (18D POST)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 400 MG/KG
Route of Application: Intratesticular
Exposure Time: (1D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Time: 24 h
Value: 156 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 65 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 410 mg/l
Test Type: LC50 Fish
Species: Cyprinus carpio
Time: 48 h
Value: 49 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
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Value: 79 - 88 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Acetic acid, glacial [or] Acetic
acid solution, [with more than 80 percent acid, by
mass]
UN#: 2789
Class: 8
Packing Group: Packing Group II
Hazard Label: Corrosive
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Acetic acid, glacial
IATA UN Number: 2789
Hazard Class: 8
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 10 35
Risk Statements: Flammable. Causes severe burns.
S: 26 36/37/39 45
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Combustible (USA) Flammable (EU).
Corrosive.
Risk Statements: Causes severe burns. Harmful in contact with
skin.
Safety Statements: Keep away from sources of ignition - no
smoking. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible). In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing, gloves,
and eye/face protection.
US Statements: Lachrymator. Target organ(s): Teeth. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
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contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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