SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 02/16/2005
Version 1.5
Section 1 - Product and Company Information
Product Name 2-BUTANOL, REAGENTPLUS(TM), 99%
Product Number B85919
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
(+/-)-2-BUTANOL 78-92-2 Yes
Formula C4H10O
Synonyms Alcool butylique secondaire (French) * s-Butanol
* sec-Butanol (ACGIH) * Butan-2-ol * Butanol-2 *
DL-Butan-2-ol * (+-)-2-Butanol * Butanol
secondaire (French) * s-Butyl alcohol * sec-Butyl
alcohol (OSHA) * 2-Butyl alcohol * Butylene
hydrate * CCS 301 * Ethylmethyl carbinol *
2-Hydroxybutane * Methylethylcarbinol *
dl-Methylethylcarbinol * 1-Methyl propanol *
1-Methyl-1-propanol * 1-Methylpropyl alcohol *
Racemic-2-butanol * S.B.A.
RTECS Number: EO1750000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable. Irritant.
Vapors may cause drowsiness and dizziness. Irritating to eyes and
respiratory system.
HMIS RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
FLASH POINT
80 掳F 27 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 1.7 % Upper: 9.8 %
AUTOIGNITION TEMP
405 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
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complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid contact with eyes, skin, and clothing. Do
not breathe vapor. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 100 PPM
USA MSHA Standard-air TWA 150 PPM (450 MG/M3)
USA OSHA. PEL 8H TWA 150 PPM (450 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 100 PPM
STEL 150 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 450 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
Molecular Weight 74.12 AMU
pH N/A
BP/BP Range 98 掳C 760 mmHg
MP/MP Range -115 掳C
Freezing Point N/A
Vapor Pressure 12.5 mmHg 20 掳C
Vapor Density 2.6 g/l
Saturated Vapor Conc. N/A
SG/Density 0.808 g/cm3
Bulk Density N/A
Odor Threshold 43 ppm
Volatile% N/A
VOC Content N/A
Water Content N/A
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Solvent Content N/A
Evaporation Rate N/A
Viscosity 0.004 Pas 15 掳C
Surface Tension 23 mN/m 20 掳C
Partition Coefficient Log Kow: 0.61
Decomposition Temp. N/A
Flash Point 80 掳F 27 掳C Method: closed cup
Explosion Limits Lower: 1.7 %
Upper: 9.8 %
Flammability N/A
Autoignition Temp 405 掳C
Refractive Index 1.397
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: BENZENE, ALCOHOLS, ETHER
ACETONE
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids, Acid chlorides, Acid anhydrides,
Oxidizing agents, Halogens, Peroxides.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, dizziness, and headache. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
2193 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Behavioral:Coma.
Skin
Rat
> 2000 mg/kg
LD50
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Intraperitoneal
Rat
1193 MG/KG
LD50
Intravenous
Rat
138 MG/KG
LD50
Intraperitoneal
Mouse
771 MG/KG
LD50
Intravenous
Mouse
764 MG/KG
LD50
Oral
Rabbit
4893 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Corneal damage. Cardiac:Pulse rate. Lungs, Thorax, or
Respiration:Dyspnea.
Intraperitoneal
Rabbit
277 MG/KG
LD50
Intraperitoneal
Guinea pig
1067 MG/KG
LD50
Intraperitoneal
Hamster
1218 MG/KG
LD50
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 5000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 7000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Musculoskeletal system.
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Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 2,300 mg/l
Test Type: EC100 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 5,000 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 3,520 mg/l
Test Type: EC50 Algae
Time: 24 h
Value: 3,400 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Butanols
UN#: 1120
Class: 3
Packing Group: Packing Group III
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Butanols
IATA UN Number: 1120
Hazard Class: 3
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xi
Indication of Danger: Irritant.
R: 10 36/37 67
Risk Statements: Flammable. Irritating to eyes and respiratory
system. Vapors may cause drowsiness and dizziness.
S: 7/9 13 24/25 26 46
Safety Statements: Keep container tightly closed and in
well-ventilated place. Keep away from food, drink, and animal
feedingstuffs. Avoid contact with skin and eyes. In case of
contact with eyes, rinse immediately with plenty of water and
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seek medical advice. If swallowed, seek medical advice
immediately and show this container or label.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable. Irritant.
Risk Statements: Irritating to eyes and respiratory system.
Vapors may cause drowsiness and dizziness.
Safety Statements: Keep container tightly closed and in
well-ventilated place. Avoid contact with skin and eyes. In case
of contact with eyes, rinse immediately with plenty of water and
seek medical advice. If swallowed, seek medical advice
immediately and show this container or label.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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