SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/15/2005
Date Updated: 05/24/2004
Version 1.2
Section 1 - Product and Company Information
Product Name DIETHYL ETHER, REAGENT GRADE
Product Number 443522
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
DIETHYL ETHER STABILIZED WITH BHT 60-29-7 No
Ingredient Name CAS # Percent SARA 313
Stabilized with: None
BUTYLATED HYDROXYTOLUENE 128-37-0 No
Formula C4H10O
Synonyms Aether * Anaesthetic ether * Anesthesia ether *
Anesthetic ether * Diaethylaether (German) *
Diethyl ether (DOT:OSHA) * Diethyl oxide *
Dwuetylowy eter (Polish) * Etere etilico
(Italian) * Ether * Ether ethylique (French) *
Ethoxyethane * Ethyl ether (ACGIH:OSHA) * Oxyde
d'ethyle (French) * RCRA waste number U117 *
Solvent ether
RTECS Number: KI5775000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Extremely Flammable (EU). Toxic (USA) Harmful (EU).
Extremely flammable. May form explosive peroxides. Harmful if
swallowed. Irritating to eyes, respiratory system and skin.
Repeated exposure may cause skin dryness or cracking. Vapors may
cause drowsiness and dizziness.
Target organ(s): Central nervous system. Kidneys.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 4
REACTIVITY: 3
NFPA RATING
HEALTH: 2
FLAMMABILITY: 4
REACTIVITY: 3
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
Peroxide Former: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
FLASH POINT
-40 掳F -40 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 1.8 % Upper: 48 %
AUTOIGNITION TEMP
160 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Water may be ineffective.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
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rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat, sparks, and
open flame.
SPECIAL REQUIREMENTS
Light sensitive. Air sensitive. Heat sensitive. Do not distill
to dryness. Refrigerate before opening.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 500 PPM
USA ACGIH TWA 400 PPM
USA MSHA Standard-air TWA 400 PPM (1200 MG/M3)
USA OSHA. PEL 8H TWA 400 PPM (1200 MG/M3)
New Zealand OEL
Remarks: check ACGIH TLV
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 300 MG/M3
Poland NDSCh 600 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 74.12 AMU
pH N/A
BP/BP Range 34.6 掳C 760 mmHg
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MP/MP Range -116 掳C
Freezing Point N/A
Vapor Pressure 442.552 mmHg 20 掳C
Vapor Density 2.6 g/l
Saturated Vapor Conc. N/A
SG/Density 0.71 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point -40 掳F -40 掳C Method: closed cup
Explosion Limits Lower: 1.8 %
Upper: 48 %
Flammability N/A
Autoignition Temp 160 掳C
Refractive Index 1.353
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May form peroxides of unknown stability.
Conditions to Avoid: Light. Heat. Air.
Materials to Avoid: Oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Kidneys. Liver. G.I. System. Skeletal
muscle.
SIGNS AND SYMPTOMS OF EXPOSURE
Contact with eyes can cause redness, tearing, and blurred
vision. Prolonged or repeated contact with skin can cause
defatting and dermatitis. Exposure can cause: Coughing, chest
pains, difficulty in breathing. Dizziness. Drowsiness. To the
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best of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Man
260 mg/kg
LDLO
Oral
Rat
1215 mg/kg
LD50
Inhalation
Mouse
31,000 ppm
LC50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Intraperitoneal
Mouse
2420 MG/KG
LD50
Intravenous
Mouse
996 MG/KG
LD50
Skin
Rabbit
>20 ML/KG
LD50
IRRITATION DATA
Eyes
Human
100 ppm
Skin
Rabbit
360 mg
Remarks: Open irritation test
Eyes
Rabbit
100 mg
Remarks: Moderate irritation effect
Skin
Guinea pig
50 mg
24H
Remarks: Severe irritation effect
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Dose: 2850 MG/L
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Cell Type: Embryo
Mutation test: DNA inhibition
Species: Hamster
Dose: 1 PPH
Cell Type: fibroblast
Mutation test: Other mutation test systems
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Daphnia magna Pimephales promelas (Fathead
minnow)
Time: 96 h
Value: 2,560 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Diethyl ether [or] Ethyl ether
UN#: 1155
Class: 3
Packing Group: Packing Group I
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: ETHYL ETHER
IATA UN Number: 1155
Hazard Class: 3
Packing Group: I
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F+ Xn
Indication of Danger: Extremely Flammable. Harmful.
R: 12 19 22 66 67
Risk Statements: Extremely flammable. May form explosive
peroxides. Harmful if swallowed. Repeated exposure may cause
skin dryness or cracking. Vapors may cause drowsiness and
dizziness.
S: 9 16 29 33
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. Do not empty
into drains. Take precautionary measures against static
discharges.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Extremely Flammable (EU).
Toxic (USA) Harmful (EU).
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Risk Statements: Extremely flammable. May form explosive
peroxides. Harmful if swallowed. Irritating to eyes, respiratory
system and skin. Repeated exposure may cause skin dryness or
cracking. Vapors may cause drowsiness and dizziness.
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. Do not empty
into drains. Take precautionary measures against static
discharges.
US Statements: Target organ(s): Central nervous system. Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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