SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/14/2005
Date Updated: 10/07/2004
Version 1.6
Section 1 - Product and Company Information
Product Name ACETYL CHLORIDE, REAGENT GRADE, 98%
Product Number 114189
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
ACETYL CHLORIDE 75-36-5 No
Formula C2H3ClO
Synonyms Acetic acid, chloride * Acetic chloride *
Ethanoyl chloride * RCRA waste number U006
RTECS Number: AO6390000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Corrosive.
Causes burns. Reacts violently with water. Harmful if swallowed.
Lachrymator.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 3
REACTIVITY: 3
SPECIAL HAZARD(S): Water reactive
NFPA RATING
HEALTH: 3
FLAMMABILITY: 3
REACTIVITY: 3
SPECIAL HAZARD(S): Water reactive
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back.
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
FLASH POINT
41 掳F 5 掳C Method: closed cup
EXPLOSION LIMITS
Lower: 7.3 % Upper: 19 %
AUTOIGNITION TEMP
734 掳C
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide.
Unsuitable: Do not use water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Flammable liquid. Vapor may travel considerable distance to
source of ignition and flash back.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
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User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat, sparks, and
open flame. Store in a cool dry place.
Incompatible Materials: Do not allow contact with water
SPECIAL REQUIREMENTS
Readily hydrolyzed. Handle and store under inert gas.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
Molecular Weight 78.5 AMU
pH N/A
BP/BP Range 50 - 52 掳C
MP/MP Range -112 掳C
Freezing Point N/A
Vapor Pressure 604.373 mmHg 20 掳C
Vapor Density 2.7 g/l
Saturated Vapor Conc. N/A
SG/Density 1.105 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 41 掳F 5 掳C Method: closed cup
Explosion Limits Lower: 7.3 %
Upper: 19 %
Flammability N/A
Autoignition Temp 734 掳C
Refractive Index 1.389
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
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N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Water, Alcohols, Oxidizing agents, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
TOXICITY DATA
Oral
Rat
910 mg/kg
LD50
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Behavioral:Excitement. Lungs, Thorax,
or Respiration:Other changes.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
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DOT
Proper Shipping Name: Acetyl chloride
UN#: 1717
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Acetyl chloride
IATA UN Number: 1717
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F C
Indication of Danger: Highly Flammable. Corrosive.
R: 11 14 34
Risk Statements: Highly flammable. Reacts violently with water.
Causes burns.
S: 9 16 26 45
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Corrosive.
Risk Statements: Causes burns. Reacts violently with water.
Harmful if swallowed.
Safety Statements: Keep away from sources of ignition - no
smoking. Keep container in a well-ventilated place. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
Keep container in a well-ventilated place.
US Statements: Lachrymator.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
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purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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